Differences in genetic expression profiles between young-age and old-age gastric adenocarcinoma using cDNA microarray for endocrine disruptor study

  • Authors:
    • Hye Won Chung
    • Seung Woo Park
    • Jae Bock Chung
    • Jin Kyung Kang
    • Ju Won Kim
    • Han-Soo Kim
    • Woo Jin Hyung
    • Sung Hoon Noh
    • Si Young Song
  • View Affiliations

  • Published online on: July 1, 2004     https://doi.org/10.3892/or.12.1.33
  • Pages: 33-39
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In the current study, we compared the differential expression profiles of genes affected by endocrine disruptor in gastric carcinomas of the young and old using cDNA microarray. Five gastric carcinoma tissues of young patients (≤35 years) were compared with 5 disease-free gastric tissues of age-matched healthy young people (experiment 1) and 5 gastric carcinoma tissues of old patients (≥65 years) (experiment 2), respectively. We hybridized the tissues with IntelliGene™ Human DNA Chip for endocrine disruption study, and identified finally the results common to the two experiments. Of the 220 genes represented on the array, 6 genes were up-regulated and 3 genes were down-regulated in the gastric carcinomas of young patients compared with those of old patients and those of the young volunteers. In conclusion, the genes affected by endocrine disruptors were differently expressed in young-age gastric carcinoma versus the old-age gastric carcinoma. So, we suggest that the gastric carcinoma in the young is the result of a genetic background that differs from that of the old and endocrine disruptors may play an important role in the carcinogenesis of gastric carcinoma in the young.

Related Articles

Journal Cover

July 2004
Volume 12 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Chung, H.W., Park, S.W., Chung, J.B., Kang, J.K., Kim, J.W., Kim, H. ... Song, S.Y. (2004). Differences in genetic expression profiles between young-age and old-age gastric adenocarcinoma using cDNA microarray for endocrine disruptor study. Oncology Reports, 12, 33-39. https://doi.org/10.3892/or.12.1.33
MLA
Chung, H. W., Park, S. W., Chung, J. B., Kang, J. K., Kim, J. W., Kim, H., Hyung, W. J., Noh, S. H., Song, S. Y."Differences in genetic expression profiles between young-age and old-age gastric adenocarcinoma using cDNA microarray for endocrine disruptor study". Oncology Reports 12.1 (2004): 33-39.
Chicago
Chung, H. W., Park, S. W., Chung, J. B., Kang, J. K., Kim, J. W., Kim, H., Hyung, W. J., Noh, S. H., Song, S. Y."Differences in genetic expression profiles between young-age and old-age gastric adenocarcinoma using cDNA microarray for endocrine disruptor study". Oncology Reports 12, no. 1 (2004): 33-39. https://doi.org/10.3892/or.12.1.33