The role of serotonin in tumour growth (Review)

  • Authors:
    • Emad J. Siddiqui
    • Cecil S. Thompson
    • Dimitri P. Mikhailidis
    • Faiz H. Mumtaz
  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/or.14.6.1593
  • Pages:1593-1597
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Abstract

Serotonin (5-hydroxytryptamine; 5HT) a monoamine neurotransmitter mediates a wide range of physiological actions in the human body. For example 5HT is implicated in psychiatric and neurological disorders and also plays a fundamental role in tumour growth, differentiation and gene expression. 5HT acts as a growth factor for several types of tumoural and non-tumoural cells. This review considers the role of 5HT and its receptors in the human body with particular reference to carcinogenesis. We conclude that 5HT causes growth proliferation and 5HT antagonists cause growth inhibition in a variety of tumour cells (e.g. prostate carcinoma, lung carcinoma and colonic carcinoma). Therefore, further studies should look into the potential use of 5HT antagonists in the treatment of cancer.

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December 2005
Volume 14 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
(total number of cites)

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APA
Siddiqui, E.J., Thompson, C.S., Mikhailidis, D.P., & Mumtaz, F.H. (2005). The role of serotonin in tumour growth (Review). Oncology Reports, 14, 1593-1597. https://doi.org/10.3892/or.14.6.1593
MLA
Siddiqui, E. J., Thompson, C. S., Mikhailidis, D. P., Mumtaz, F. H."The role of serotonin in tumour growth (Review)". Oncology Reports 14.6 (2005): 1593-1597.
Chicago
Siddiqui, E. J., Thompson, C. S., Mikhailidis, D. P., Mumtaz, F. H."The role of serotonin in tumour growth (Review)". Oncology Reports 14, no. 6 (2005): 1593-1597. https://doi.org/10.3892/or.14.6.1593