Anti-apoptotic N-cadherin signaling and its prognostic implication in human hepatocellular carcinomas

  • Authors:
    • Geum-Youn Gwak
    • Jung-Hwan Yoon
    • Su Jong Yu
    • Su Cheol Park
    • Ja June Jang
    • Kyoung Bun Lee
    • Sung-Hee Lee
    • Soo-Mi Lee
    • Chan Soo Shin
    • Kyung-Suk Suh
    • Hyo-Suk Lee
  • View Affiliations

  • Published online on: May 1, 2006     https://doi.org/10.3892/or.15.5.1117
  • Pages: 1117-1123
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Abstract

N-cadherin signaling has recently been implicated in the progression of certain epithelial tumors by promoting invasion and dissemination of cancer cells. N-cadherin has also been reported to exert an anti-apoptotic effect. In this study, we attempted to evaluate the participation of this adhesion molecule in the progression of human hepatocellular carcinomas (HCCs) by analyzing its anti-apoptotic signaling as well as its prognostic implication in HCC patients. N-cadherin was found to be expressed in human HCCs. We established a stable human HCC cell line expressing a truncated N-cadherin, NCadΔC, with a dominant-negative action. NCadΔC-expressing cells were more susceptible to bile acid-induced apoptosis than control cells. N-cadherin was found to complex with procaspase-8, and this association was diminished in NCadΔC-expressing cells, leading to enhanced procaspase-8 recruitment to death-inducing signaling complex following bile acid treatment. A clinicopathological analysis in patients who had undergone surgical resection for HCC revealed that tumoral N-cadherin up-regulation was significantly related to poor recurrence-free and overall survival. Our findings implicate N-cadherin signaling as contributing to HCC progression by exerting anti-apoptotic effects. Thus, we suggest that the selective interruption of this signaling may have therapeutic potential.

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May 2006
Volume 15 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Gwak G, Yoon J, Yu SJ, Park SC, Jang JJ, Lee KB, Lee S, Lee S, Shin CS, Suh K, Suh K, et al: Anti-apoptotic N-cadherin signaling and its prognostic implication in human hepatocellular carcinomas. Oncol Rep 15: 1117-1123, 2006
APA
Gwak, G., Yoon, J., Yu, S.J., Park, S.C., Jang, J.J., Lee, K.B. ... Lee, H. (2006). Anti-apoptotic N-cadherin signaling and its prognostic implication in human hepatocellular carcinomas. Oncology Reports, 15, 1117-1123. https://doi.org/10.3892/or.15.5.1117
MLA
Gwak, G., Yoon, J., Yu, S. J., Park, S. C., Jang, J. J., Lee, K. B., Lee, S., Lee, S., Shin, C. S., Suh, K., Lee, H."Anti-apoptotic N-cadherin signaling and its prognostic implication in human hepatocellular carcinomas". Oncology Reports 15.5 (2006): 1117-1123.
Chicago
Gwak, G., Yoon, J., Yu, S. J., Park, S. C., Jang, J. J., Lee, K. B., Lee, S., Lee, S., Shin, C. S., Suh, K., Lee, H."Anti-apoptotic N-cadherin signaling and its prognostic implication in human hepatocellular carcinomas". Oncology Reports 15, no. 5 (2006): 1117-1123. https://doi.org/10.3892/or.15.5.1117