Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1)

  • Authors:
    • Michiyuki Hakozaki
    • Hiroshi Hojo
    • Shinichi Kikuchi
    • Masafumi Abe
  • View Affiliations

  • Published online on: January 1, 2007     https://doi.org/10.3892/or.17.1.169
  • Pages: 169-173
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Abstract

alignant rhabdoid tumor (MRT) is a rare and highly aggressive tumor presenting in the kidney and soft tissue in childhood. However, effective treatment for MRT has not been established. We investigated the antitumor effect of etodolac, a selective cyclooxygenase-2 inhibitor, on MRT cells in vitro using the MRT cell line FRTK-1. Etodolac induced apoptosis of FRTK-1 cells through activation of caspase-8, -9 and -3. Moreover, several caspase inhibitors completely or partially inhibited etodolac-induced apoptosis. Our data indicated that etodolac had an antitumor effect on MRT cells and holds promise as a novel therapeutic strategy for MRT.

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January 2007
Volume 17 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hakozaki M, Hojo H, Kikuchi S and Abe M: Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1). Oncol Rep 17: 169-173, 2007
APA
Hakozaki, M., Hojo, H., Kikuchi, S., & Abe, M. (2007). Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1). Oncology Reports, 17, 169-173. https://doi.org/10.3892/or.17.1.169
MLA
Hakozaki, M., Hojo, H., Kikuchi, S., Abe, M."Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1)". Oncology Reports 17.1 (2007): 169-173.
Chicago
Hakozaki, M., Hojo, H., Kikuchi, S., Abe, M."Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1)". Oncology Reports 17, no. 1 (2007): 169-173. https://doi.org/10.3892/or.17.1.169