Regulation of the HIF-1α stability by histone deacetylases

  • Authors:
    • Se-Hee Kim
    • Joo-Won Jeong
    • Jeong Ae Park
    • Ji-Won Lee
    • Ji Hae Seo
    • Bo-Kyung Jung
    • Moon-Kyoung Bae
    • Kyu-Won Kim
  • View Affiliations

  • Published online on: March 1, 2007     https://doi.org/10.3892/or.17.3.647
  • Pages: 647-651
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Abstract

Histone deacetylase inhibitors (HDACIs) are currently in clinical trials partly due to their potent anti-angiogenic effects. However, the detailed mechanism of their action is unclear. Here, we observed that several HDACIs (TSA, SB, Apicidin, and VPA) dramatically decreased HIF-1α protein level and transcriptional activity of HIF-1 in human and mouse tumor cell lines. Furthermore, class I HDACs, HDAC1 and 3 enhanced HIF-1α stability and HIF-1 transactivation function in hypoxic conditions. In addition, immunoprecipitation and in vitro binding assays revealed that HDAC1 and 3 directly bind to the oxygen-dependent degradation domain of HIF-1α. Collectively, these results suggest that HDAC1 and 3 are considered as a positive regulator of HIF-1α stability via direct interaction and may play an important role in HIF-1-induced tumor angiogenesis.

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March 2007
Volume 17 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kim S, Jeong J, Park JA, Lee J, Seo JH, Jung B, Bae M and Kim K: Regulation of the HIF-1α stability by histone deacetylases. Oncol Rep 17: 647-651, 2007
APA
Kim, S., Jeong, J., Park, J.A., Lee, J., Seo, J.H., Jung, B. ... Kim, K. (2007). Regulation of the HIF-1α stability by histone deacetylases. Oncology Reports, 17, 647-651. https://doi.org/10.3892/or.17.3.647
MLA
Kim, S., Jeong, J., Park, J. A., Lee, J., Seo, J. H., Jung, B., Bae, M., Kim, K."Regulation of the HIF-1α stability by histone deacetylases". Oncology Reports 17.3 (2007): 647-651.
Chicago
Kim, S., Jeong, J., Park, J. A., Lee, J., Seo, J. H., Jung, B., Bae, M., Kim, K."Regulation of the HIF-1α stability by histone deacetylases". Oncology Reports 17, no. 3 (2007): 647-651. https://doi.org/10.3892/or.17.3.647