Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells

  • Authors:
    • Jong-Wook Park
    • Kyung Jin Woo
    • Jung-Tae Lee
    • Jun Hee Lim
    • Tae-Jin Lee
    • Sang Hyun Kim
    • Yung Hyun Choi
    • Taeg Kyu Kwon
  • View Affiliations

  • Published online on: November 1, 2007     https://doi.org/10.3892/or.18.5.1269
  • Pages: 1269-1273
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Abstract

Resveratrol (3,4',5 tri-hydroxystilbene), a naturally occurring polyphenolic compound highly enriched in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. Resveratrol-induced dose-dependent apoptotic cell death in colon carcinoma cells, was measured by FACS analysis. Treatment of HT29 human colon carcinoma cells with resveratrol was found to induce a number of signature ER stress markers; phosphorylation of eukaryotic initiation factor-2α (eIF-2α), ER stress-specific XBP1 splicing and CCAAT/enhancer-binding protein-homologous protein (CHOP). In addition, resveratrol induced up-regulation of glucose-regulated protein (GRP)-78, suggesting the induction of ER stress. Furthermore, the inhibition of caspase-4 activity by z-LEVD-fmk significantly reduced resveratrol-induced apoptosis. Taken together, the present study therefore provides strong evidence to support an important role of ER stress response in mediating the resveratrol-induced apoptosis.

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November 2007
Volume 18 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Park J, Woo KJ, Lee J, Lim JH, Lee T, Kim SH, Choi YH and Kwon TK: Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Oncol Rep 18: 1269-1273, 2007
APA
Park, J., Woo, K.J., Lee, J., Lim, J.H., Lee, T., Kim, S.H. ... Kwon, T.K. (2007). Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Oncology Reports, 18, 1269-1273. https://doi.org/10.3892/or.18.5.1269
MLA
Park, J., Woo, K. J., Lee, J., Lim, J. H., Lee, T., Kim, S. H., Choi, Y. H., Kwon, T. K."Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells". Oncology Reports 18.5 (2007): 1269-1273.
Chicago
Park, J., Woo, K. J., Lee, J., Lim, J. H., Lee, T., Kim, S. H., Choi, Y. H., Kwon, T. K."Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells". Oncology Reports 18, no. 5 (2007): 1269-1273. https://doi.org/10.3892/or.18.5.1269