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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2008 Volume 19 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Disease family history and modification of breast cancer risk in common BRCA2 variants

  • Authors:
    • Ian Jonathan Seymour
    • Silvia Casadei
    • Valentina Zampiga
    • Simonetta Rosato
    • Rita Danesi
    • Fabio Falcini
    • Miria Strada
    • Nori Morini
    • Carlo Naldoni
    • Angelo Paradiso
    • Stefania Tommasi
    • Francesco Schittulli
    • Dino Amadori
    • Daniele Calistri

  • View Affiliations / Copyright

    Affiliations: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), 47014 Meldola (FC), Italy
  • Pages: 783-786
    |
    Published online on: March 1, 2008
       https://doi.org/10.3892/or.19.3.783
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Abstract

A number of BRCA1 and BRCA2 polymorphisms have been extensively studied in order to test their association with breast cancer risk. Subsequently, discordant results were reported. In the present study, the genotypes of one BRCA1 (Q356R) and three BRCA2 (203G>A, N372H, IVS21-66T>C) common variants were evaluated in a series of 252 breast cancer patients, 155 age-matched controls and analysed in relation to family history (low- or high-risk) and BRCA1/2 mutation status. A complete analysis of the BRCA1/2 coding regions was performed on the 217 women from high-risk families and 44 BRCA1/2 mutation carriers were identifed. According to a dominant inheritance model, the BRCA2 IVS21-66T>C variant showed a 1.79-fold (95% CI, 1.16-2.78; P=0.009) increased breast cancer risk for the overall series. The BRCA2 N372H polymorphism was associated with a 2.29-fold (95% CI, 1.16-4.49; P=0.016) increased risk in the subgroup of high-risk families with no BRCA1/2 mutations. Conversely, the BRCA1 Q356R and BRCA2 203G>A polymorphisms did not show any significant associations with breast cancer risk. In conclusion, the analysis of some BRCA2 variants could help to identify women at a higher risk of developing breast cancer who could be candidates for chemoprevention protocols.

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Copy and paste a formatted citation
Spandidos Publications style
Seymour IJ, Casadei S, Zampiga V, Rosato S, Danesi R, Falcini F, Strada M, Morini N, Naldoni C, Paradiso A, Paradiso A, et al: Disease family history and modification of breast cancer risk in common BRCA2 variants. Oncol Rep 19: 783-786, 2008.
APA
Seymour, I.J., Casadei, S., Zampiga, V., Rosato, S., Danesi, R., Falcini, F. ... Calistri, D. (2008). Disease family history and modification of breast cancer risk in common BRCA2 variants. Oncology Reports, 19, 783-786. https://doi.org/10.3892/or.19.3.783
MLA
Seymour, I. J., Casadei, S., Zampiga, V., Rosato, S., Danesi, R., Falcini, F., Strada, M., Morini, N., Naldoni, C., Paradiso, A., Tommasi, S., Schittulli, F., Amadori, D., Calistri, D."Disease family history and modification of breast cancer risk in common BRCA2 variants". Oncology Reports 19.3 (2008): 783-786.
Chicago
Seymour, I. J., Casadei, S., Zampiga, V., Rosato, S., Danesi, R., Falcini, F., Strada, M., Morini, N., Naldoni, C., Paradiso, A., Tommasi, S., Schittulli, F., Amadori, D., Calistri, D."Disease family history and modification of breast cancer risk in common BRCA2 variants". Oncology Reports 19, no. 3 (2008): 783-786. https://doi.org/10.3892/or.19.3.783
Copy and paste a formatted citation
x
Spandidos Publications style
Seymour IJ, Casadei S, Zampiga V, Rosato S, Danesi R, Falcini F, Strada M, Morini N, Naldoni C, Paradiso A, Paradiso A, et al: Disease family history and modification of breast cancer risk in common BRCA2 variants. Oncol Rep 19: 783-786, 2008.
APA
Seymour, I.J., Casadei, S., Zampiga, V., Rosato, S., Danesi, R., Falcini, F. ... Calistri, D. (2008). Disease family history and modification of breast cancer risk in common BRCA2 variants. Oncology Reports, 19, 783-786. https://doi.org/10.3892/or.19.3.783
MLA
Seymour, I. J., Casadei, S., Zampiga, V., Rosato, S., Danesi, R., Falcini, F., Strada, M., Morini, N., Naldoni, C., Paradiso, A., Tommasi, S., Schittulli, F., Amadori, D., Calistri, D."Disease family history and modification of breast cancer risk in common BRCA2 variants". Oncology Reports 19.3 (2008): 783-786.
Chicago
Seymour, I. J., Casadei, S., Zampiga, V., Rosato, S., Danesi, R., Falcini, F., Strada, M., Morini, N., Naldoni, C., Paradiso, A., Tommasi, S., Schittulli, F., Amadori, D., Calistri, D."Disease family history and modification of breast cancer risk in common BRCA2 variants". Oncology Reports 19, no. 3 (2008): 783-786. https://doi.org/10.3892/or.19.3.783
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