Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells

  • Authors:
    • Raffaella Ravizza
    • Marzia B. Gariboldi
    • Roberta Molteni
    • Elena Monti
  • View Affiliations

  • Published online on: September 1, 2008     https://doi.org/10.3892/or_00000051
  • Pages:625-630
Metrics: HTML 0 views | PDF 0 views     Cited By: 0 citations

Abstract

Essential oils from various aromatic plants have been reported to exert chemopreventive and/or antitumor effects. In addition, a number of studies have shown the ability of chemopreventive phytochemicals to increase the sensitivity of cancer cells to conventional anticancer drugs. The success of chemotherapeutic agents is often hindered by the development of drug resistance, with multidrug resistant (MDR) phenotypes reported in a number of tumors, generally involving reduced intracellular drug accumulation due to increased drug efflux by membrane transporters. In the present study, the effects of linalool (LIN), a monoterpene alcohol found in the essential oils from many aromatic plants, on the growth of two human breast adenocarcinoma cell lines, MCF7 WT and multidrug resistant MCF7 AdrR, were investigated, both as a single agent and in combination with doxorubicin (DOX). The results reported here show that LIN only moderately inhibits cell proliferation; interestingly, however, subtoxic concentrations of LIN potentiate DOX-induced cytotoxicity and pro-apoptotic effects in both cell lines. A significant synergism can be observed in MCF7 AdrR cells, which may be due, at least in part, to the ability of LIN to increase DOX accumulation and to induce a decrease in Bcl-xL levels. In summary, the results of the present study suggest that LIN may improve the therapeutic index of anthracyclines in the management of breast cancer, especially in MDR tumors.

Related Articles

Journal Cover

September 2008
Volume 20 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Ravizza, R., Gariboldi, M.B., Molteni, R., & Monti, E. (2008). Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells. Oncology Reports, 20, 625-630. https://doi.org/10.3892/or_00000051
MLA
Ravizza, R., Gariboldi, M. B., Molteni, R., Monti, E."Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells". Oncology Reports 20.3 (2008): 625-630.
Chicago
Ravizza, R., Gariboldi, M. B., Molteni, R., Monti, E."Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells". Oncology Reports 20, no. 3 (2008): 625-630. https://doi.org/10.3892/or_00000051