The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1

  • Authors:
    • Ioannis Panagopoulos
    • Emely Möller
    • Anna Collin
    • Fredrik Mertens
  • View Affiliations

  • Published online on: November 1, 2008     https://doi.org/10.3892/or_00000105
  • Pages: 1029-1033
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Abstract

POU5F1, which encodes a transcriptional factor, has two alternatively spliced transcripts, 1 and 2, as well as six pseudogenes. Transcript 1 is considered to be a key regulator of cellular pluripotency and self-renewal. The POU5F1 pseudogene, POU5F1P1 on 8q24, encodes a protein with 95% homology with the isoform 1 of POU5F1. It is located 15 kbp downstream of the SNP rs6983267, which is strongly associated with an increased risk of prostate and colon cancer, and within the amplified region in a variety of human malignancies. The previous finding of expressed sequence tags suggests that POU5F1P1 can be expressed. We showed that a putative POU5F1P1 protein is localized in the nucleus, acts as a transcriptional activator and regulates the expression in a similar way to the POU5F1 isoform 1. However, POU5F1P1 was a weaker activator than isoform 1 of POU5F1, possibly due to the amino acid substitutions.

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November 2008
Volume 20 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Panagopoulos, I., Möller, E., Collin, A., & Mertens, F. (2008). The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. Oncology Reports, 20, 1029-1033. https://doi.org/10.3892/or_00000105
MLA
Panagopoulos, I., Möller, E., Collin, A., Mertens, F."The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1". Oncology Reports 20.5 (2008): 1029-1033.
Chicago
Panagopoulos, I., Möller, E., Collin, A., Mertens, F."The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1". Oncology Reports 20, no. 5 (2008): 1029-1033. https://doi.org/10.3892/or_00000105