Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line

  • Authors:
    • Zhenya Zhang
    • Peijuan Zhang
    • Michito Hamada
    • Satoru Takahashi
    • Guoqing Xing
    • Jiqiang Liu
    • Norio Sugiura
  • View Affiliations

  • Published online on: November 1, 2008     https://doi.org/10.3892/or_00000115
  • Pages:1099-1103
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Abstract

Bladder cancer is a common but serious malignancy. It is widely accepted that chemoprevention may be an effective way to decrease the rate of recurrence and morbidity. We first determined antigrowth and apoptosis-induction activity of fucoxanthin from dietary Laminaria japonica against EJ-1 human bladder cancers. Fucoxanthin significantly reduced the cell viability in a dose- and time-dependent manner. The induction of apoptosis in EJ-1 cells was characterized by morphological changes, DNA ladder, and increased percentage of hypodiploid cells, activating caspase-3 activity. The ratio of apoptotic cells reached >93% after treatment for 72 h with 20 µM fucoxanthin. The findings obtained indicate that fucoxanthin may act as a chemopreventive and/or chemotherapeutic carotenoid in bladder cancer cells by modulating cell viability.

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November 2008
Volume 20 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Zhang, Z., Zhang, P., Hamada, M., Takahashi, S., Xing, G., Liu, J., & Sugiura, N. (2008). Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line. Oncology Reports, 20, 1099-1103. https://doi.org/10.3892/or_00000115
MLA
Zhang, Z., Zhang, P., Hamada, M., Takahashi, S., Xing, G., Liu, J., Sugiura, N."Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line". Oncology Reports 20.5 (2008): 1099-1103.
Chicago
Zhang, Z., Zhang, P., Hamada, M., Takahashi, S., Xing, G., Liu, J., Sugiura, N."Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line". Oncology Reports 20, no. 5 (2008): 1099-1103. https://doi.org/10.3892/or_00000115