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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2008 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist

  • Authors:
    • Stephan Seitz
    • Florian Hohla
    • Andrew V. Schally
    • Angelika Moder
    • Joerg B. Engel
    • Felicitas Horn
    • Josef Varga
    • Marta Zarandi
    • Olaf Ortmann
    • Frank Köster
    • Stefan Buchholz

  • View Affiliations / Copyright

    Affiliations: Veterans Affairs Medical Center Miami FL and South Florida VA Foundation for Research and Education, Miami FL 33101, USA
  • Pages: 1289-1294
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/or_00000143
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Abstract

GHRH antagonists have been shown to inhibit growth of various human cancer cell lines xenografted into nude mice including estrogen receptor negative human breast cancers. Previous observations also suggest that GHRH locally produced in diverse neoplasms including breast cancer might directly affect proliferation of tumor cells. In the present study we demonstrate that a novel highly potent GHRH antagonist JMR-132 strongly inhibits the proliferation of both estrogen receptor negative SKBR 3 and estrogen receptor positive ZR 75 human breast cancer cell lines in vitro. The proliferation in vitro of ZR 75 and SKBR 3 was increased after direct stimulation with GHRH(1-29)NH2. The GHRH antagonist JMR-132 had a significant antiproliferative activity in the absence of GHRH and nullified the proliferative effect of GHRH in these cell lines. SKBR 3 and ZR 75 expressed the GHRH ligand as well as the pituitary type of GHRH-receptor, which likely appears to mediate the antiproliferative mechanisms in these cell lines. These in vitro results suggest that JMR-132 is a potent inhibitor of breast cancer growth, independent of the estrogen receptor status. Further investigations on the combination treatment with endocrine agents affecting the estrogen pathway and GRHR antagonists are needed in order to improve the treatment of breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Seitz S, Hohla F, Schally AV, Moder A, Engel JB, Horn F, Varga J, Zarandi M, Ortmann O, Köster F, Köster F, et al: Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist. Oncol Rep 20: 1289-1294, 2008.
APA
Seitz, S., Hohla, F., Schally, A.V., Moder, A., Engel, J.B., Horn, F. ... Buchholz, S. (2008). Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist. Oncology Reports, 20, 1289-1294. https://doi.org/10.3892/or_00000143
MLA
Seitz, S., Hohla, F., Schally, A. V., Moder, A., Engel, J. B., Horn, F., Varga, J., Zarandi, M., Ortmann, O., Köster, F., Buchholz, S."Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist". Oncology Reports 20.5 (2008): 1289-1294.
Chicago
Seitz, S., Hohla, F., Schally, A. V., Moder, A., Engel, J. B., Horn, F., Varga, J., Zarandi, M., Ortmann, O., Köster, F., Buchholz, S."Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist". Oncology Reports 20, no. 5 (2008): 1289-1294. https://doi.org/10.3892/or_00000143
Copy and paste a formatted citation
x
Spandidos Publications style
Seitz S, Hohla F, Schally AV, Moder A, Engel JB, Horn F, Varga J, Zarandi M, Ortmann O, Köster F, Köster F, et al: Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist. Oncol Rep 20: 1289-1294, 2008.
APA
Seitz, S., Hohla, F., Schally, A.V., Moder, A., Engel, J.B., Horn, F. ... Buchholz, S. (2008). Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist. Oncology Reports, 20, 1289-1294. https://doi.org/10.3892/or_00000143
MLA
Seitz, S., Hohla, F., Schally, A. V., Moder, A., Engel, J. B., Horn, F., Varga, J., Zarandi, M., Ortmann, O., Köster, F., Buchholz, S."Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist". Oncology Reports 20.5 (2008): 1289-1294.
Chicago
Seitz, S., Hohla, F., Schally, A. V., Moder, A., Engel, J. B., Horn, F., Varga, J., Zarandi, M., Ortmann, O., Köster, F., Buchholz, S."Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist". Oncology Reports 20, no. 5 (2008): 1289-1294. https://doi.org/10.3892/or_00000143
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