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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2008 Volume 20 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2008 Volume 20 Issue 6

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Article

TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells

  • Authors:
    • Zhi Gang Wang
    • Takuya Fukazawa
    • Toshio Nishikawa
    • Nobuyuki Watanabe
    • Kazufumi Sakurama
    • Takayuki Motoki
    • Munenori Takaoka
    • Shinji Hatakeyama
    • Osamu Omori
    • Toshiaki Ohara
    • Shunsuke Tanabe
    • Yasuhiro Fujiwara
    • Yasuhiro Shirakawa
    • Tomoki Yamatsuji
    • Noriaki Tanaka
    • Yoshio Naomoto
  • View Affiliations / Copyright

    Affiliations: College of Life Science, Inner Mongolia University, The Key Laboratory of Mammal Reproductive Biology and Biotechnology, Ministry of Education, Huhhot 010021, P.R. China
  • Pages: 1473-1477
    |
    Published online on: December 1, 2008
       https://doi.org/10.3892/or_00000168
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Abstract

Esophageal cancer is one of the most aggressive cancers in the world. Novel preventive and therapeutic strategies tend to target the key molecules involved in the signaling transduction pathways for cell growth. It is known that FAK and mTOR are important controllers of cell growth. TAE226, a novel small molecule compound, is a potent ATP competitive inhibitor of FAK and IGF-IR. TAE226 can block FAK and IGF-IR signaling pathways. The purpose of this study was to explore the inhibitory effects on mTOR signaling and the mechanism of cell growth suppression by TAE226. We examined the expression of mTOR and S6 in esophageal cancer cells (SEG-1) and normal esophageal epithelial cells (KOB-13) and the efficacy of TAE226 against SEG-1 cells. mTOR and S6 were overexpressed in SEG-1 cells compared with KOB-13 cells. TAE226 inhibited the expression of mTOR, Akt, p70S6K and S6 as well as the phosphorylation of mTOR (Ser2448), Akt (Ser473), p70S6K (Thr389) and S6 (Ser240/244). As a result, TAE226 induced a dose-dependent decrease in cell growth (number) and damage in the cell shape. Together, these data show that TAE226 has potent inhibitory effects on mTOR signaling and esophageal cancer cell growth indicating that TAE226 has potential application in esophageal cancer treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Wang ZG, Fukazawa T, Nishikawa T, Watanabe N, Sakurama K, Motoki T, Takaoka M, Hatakeyama S, Omori O, Ohara T, Ohara T, et al: TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. Oncol Rep 20: 1473-1477, 2008.
APA
Wang, Z.G., Fukazawa, T., Nishikawa, T., Watanabe, N., Sakurama, K., Motoki, T. ... Naomoto, Y. (2008). TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. Oncology Reports, 20, 1473-1477. https://doi.org/10.3892/or_00000168
MLA
Wang, Z. G., Fukazawa, T., Nishikawa, T., Watanabe, N., Sakurama, K., Motoki, T., Takaoka, M., Hatakeyama, S., Omori, O., Ohara, T., Tanabe, S., Fujiwara, Y., Shirakawa, Y., Yamatsuji, T., Tanaka, N., Naomoto, Y."TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells". Oncology Reports 20.6 (2008): 1473-1477.
Chicago
Wang, Z. G., Fukazawa, T., Nishikawa, T., Watanabe, N., Sakurama, K., Motoki, T., Takaoka, M., Hatakeyama, S., Omori, O., Ohara, T., Tanabe, S., Fujiwara, Y., Shirakawa, Y., Yamatsuji, T., Tanaka, N., Naomoto, Y."TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells". Oncology Reports 20, no. 6 (2008): 1473-1477. https://doi.org/10.3892/or_00000168
Copy and paste a formatted citation
x
Spandidos Publications style
Wang ZG, Fukazawa T, Nishikawa T, Watanabe N, Sakurama K, Motoki T, Takaoka M, Hatakeyama S, Omori O, Ohara T, Ohara T, et al: TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. Oncol Rep 20: 1473-1477, 2008.
APA
Wang, Z.G., Fukazawa, T., Nishikawa, T., Watanabe, N., Sakurama, K., Motoki, T. ... Naomoto, Y. (2008). TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. Oncology Reports, 20, 1473-1477. https://doi.org/10.3892/or_00000168
MLA
Wang, Z. G., Fukazawa, T., Nishikawa, T., Watanabe, N., Sakurama, K., Motoki, T., Takaoka, M., Hatakeyama, S., Omori, O., Ohara, T., Tanabe, S., Fujiwara, Y., Shirakawa, Y., Yamatsuji, T., Tanaka, N., Naomoto, Y."TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells". Oncology Reports 20.6 (2008): 1473-1477.
Chicago
Wang, Z. G., Fukazawa, T., Nishikawa, T., Watanabe, N., Sakurama, K., Motoki, T., Takaoka, M., Hatakeyama, S., Omori, O., Ohara, T., Tanabe, S., Fujiwara, Y., Shirakawa, Y., Yamatsuji, T., Tanaka, N., Naomoto, Y."TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells". Oncology Reports 20, no. 6 (2008): 1473-1477. https://doi.org/10.3892/or_00000168
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