AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells

  • Authors:
    • Wei Pan
    • Hui Yang
    • Cong Cao
    • Xiuzu Song
    • Brittany Wallin
    • Rebecca Kivlin
    • Shan Lu
    • Gang Hu
    • Wen Di
    • Yinsheng Wan
  • View Affiliations

  • Published online on: December 1, 2008     https://doi.org/10.3892/or_00000179
  • Pages:1553-1559
0

Abstract

AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase, serves as an energy sensor in all eukaryotic cells. Recent findings suggest that AMPK activation strongly suppresses cell proliferation and induces cell apoptosis in a variety of cancer cells. Our study demonstrated that chemopreventive agent curcumin strongly activates AMPK in a p38-dependent manner in CaOV3 ovarian cancer cells. Pretreatment of cells with compound C (AMPK inhibitor) and SB203580 (p38 inhibitor) attenuates curcumin-induced cell death. We also observed that curcumin induces p53 phosphorylation (Ser 15) and both compound C and SB203580 pretreatment inhibit p53 phosphorylation. Collectively, our data suggest that AMPK is a new molecular target of curcumin and AMPK activation partially contributes to the cytotoxic effect of curcumin in ovarian cancer cells.

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December 2008
Volume 20 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2015 Impact Factor: 2.486
Ranked #31/211 Oncology
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APA
Pan, W., Yang, H., Cao, C., Song, X., Wallin, B., Kivlin, R. ... Wan, Y. (2008). AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncology Reports, 20, 1553-1559. https://doi.org/10.3892/or_00000179
MLA
Pan, W., Yang, H., Cao, C., Song, X., Wallin, B., Kivlin, R., Lu, S., Hu, G., Di, W., Wan, Y."AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells". Oncology Reports 20.6 (2008): 1553-1559.
Chicago
Pan, W., Yang, H., Cao, C., Song, X., Wallin, B., Kivlin, R., Lu, S., Hu, G., Di, W., Wan, Y."AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells". Oncology Reports 20, no. 6 (2008): 1553-1559. https://doi.org/10.3892/or_00000179