Phase I study of combination chemotherapy with irinotecan hydrochloride and nedaplatin for cervical squamous cell carcinoma: Japanese gynecologic oncology group study

  • Authors:
    • Kaichiro Yamamoto
    • Katsuji Kokawa
    • Naohiko Umesaki
    • Ryuichiro Nishimura
    • Kazuo Hasegawa
    • Ikuo Konishi
    • Fumitaka Saji
    • Masato Nishida
    • Hiroshi Noguchi
    • Ken Takizawa
  • View Affiliations

  • Published online on: April 1, 2009     https://doi.org/10.3892/or_00000316
  • Pages: 1005-1009
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of this study (JGOG1063) was to determine the recommended dose (RD) for combination chemotherapy with irinotecan hydrochloride (CPT-11) and nedaplatin (NDP) for advanced cervical squamous cell carcinoma. CPT-11 was given intravenously in fixed doses of 60 mg/m2 on days 1 and 8 and NDP, in escalating doses, on day 1, every 4 weeks. A total of 15 patients were enrolled in the study. At level 1 (NDP: 50 mg/m2), one of the 3 patients developed grade 3 diarrhea, so 3 additional patients were enrolled at this level. As none of the 3 additional patients exhibited dose-limiting toxicity, level 1 was elevated to level 2 (NDP: 60 mg/m2). The maximum tolerated dose was not reached, even at the highest dose level (level 4; NDP: 80 mg/m2). No further dose escalation was carried out, and level 4 (CPT-11: 60 mg/m2, NDP: 80 mg/m2) was determined as the RD.

Related Articles

Journal Cover

April 2009
Volume 21 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Yamamoto, K., Kokawa, K., Umesaki, N., Nishimura, R., Hasegawa, K., Konishi, I. ... Takizawa, K. (2009). Phase I study of combination chemotherapy with irinotecan hydrochloride and nedaplatin for cervical squamous cell carcinoma: Japanese gynecologic oncology group study. Oncology Reports, 21, 1005-1009. https://doi.org/10.3892/or_00000316
MLA
Yamamoto, K., Kokawa, K., Umesaki, N., Nishimura, R., Hasegawa, K., Konishi, I., Saji, F., Nishida, M., Noguchi, H., Takizawa, K."Phase I study of combination chemotherapy with irinotecan hydrochloride and nedaplatin for cervical squamous cell carcinoma: Japanese gynecologic oncology group study". Oncology Reports 21.4 (2009): 1005-1009.
Chicago
Yamamoto, K., Kokawa, K., Umesaki, N., Nishimura, R., Hasegawa, K., Konishi, I., Saji, F., Nishida, M., Noguchi, H., Takizawa, K."Phase I study of combination chemotherapy with irinotecan hydrochloride and nedaplatin for cervical squamous cell carcinoma: Japanese gynecologic oncology group study". Oncology Reports 21, no. 4 (2009): 1005-1009. https://doi.org/10.3892/or_00000316