CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer

  • Authors:
    • Hirokazu Okayama
    • Kensuke Kumamoto
    • Katsuharu Saitou
    • Suguru Hayase
    • Yasuhide Kofunato
    • Yu Sato
    • Kotaro Miyamoto
    • Izumi Nakamura
    • Shinji Ohki
    • Kouji Sekikawa
    • Seiichi Takenoshita
  • View Affiliations

  • Published online on: October 1, 2009     https://doi.org/10.3892/or_00000496
  • Pages: 745-755
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Abstract

The aim of this study was to examine the expression of CD44v6, CD54, Cdx2, CXCL5, Cyclin B1, MMP-7, nm23, RCAS1 and Survivin in primary gastric cancer and to investigate whether these molecules were useful in predicting the lymph node status. They were selected as candidates for indicators of lymph node metastasis from various kinds of cancer-associated genes reported previously. In 135 cases of radically resected primary gastric adenocarcinoma, we investigated the association between the expression of these molecules and clinocopathologic factors by immunohistochemistry. The results revealed that the expression of CD44v6 and MMP-7 were significantly associated with lymph node status. By contrast, nuclear Cdx2 expression was found to be inversely correlated with lymph node metastasis. Moreover, multivariate analysis demonstrated that CD44v6, MMP-7 and nuclear Cdx2 were independent predictors for lymph node status. In conclusion, our results suggest that positive expression of both CD44v6 and MMP-7, and negative expression of nuclear Cdx2 may serve as powerful predictors of lymph node metastasis in gastric cancer. Combined evaluation of these markers could be further useful to predict lymph node status clinically.

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October 2009
Volume 22 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Okayama, H., Kumamoto, K., Saitou, K., Hayase, S., Kofunato, Y., Sato, Y. ... Takenoshita, S. (2009). CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer. Oncology Reports, 22, 745-755. https://doi.org/10.3892/or_00000496
MLA
Okayama, H., Kumamoto, K., Saitou, K., Hayase, S., Kofunato, Y., Sato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Sekikawa, K., Takenoshita, S."CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer". Oncology Reports 22.4 (2009): 745-755.
Chicago
Okayama, H., Kumamoto, K., Saitou, K., Hayase, S., Kofunato, Y., Sato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Sekikawa, K., Takenoshita, S."CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer". Oncology Reports 22, no. 4 (2009): 745-755. https://doi.org/10.3892/or_00000496