Genetic and molecular alterations associated with oral squamous cell cancer (Review)

  • Authors:
    • Mario Pérez-Sayáns
    • José M. Somoza-Martín
    • Francisco Barros-Angueira
    • María D. Reboiras-López
    • José M. Gándara Rey
    • Abel García-García
  • View Affiliations

  • Published online on: Tuesday, December 1, 2009
  • Pages: 1277-1282 DOI: 10.3892/or_00000565

Abstract

The development of oral squamous cell cancer (OSCC) is a multistep process involving the accumulation of multiple genetic alterations modulated by genetic pre-disposition and environmental influences such as tobacco and alcohol use, chronic inflammation, and viral infections. All of these factors can lead to a wide range of genetic and molecular alterations that can be detected using a range of molecular studies. The alterations mostly affect two large groups of genes: oncogenes and tumor suppressor genes, which can be either inactivated or overexpressed through mutations, loss of heterozygosity, deletions, or epigenetic modifications such as methylation. Other molecules that are closely associated with tumor pathogenesis and prognosis also exist and warrant further study. Important advances in molecular biology are helping to shed light on oral cancer and thus aiding in the early diagnosis and development of new personalized treatment approaches. The purpose of the review is to explore the genetic and molecular alterations associated with OSCC.

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December 2009
Volume 22 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2015 Impact Factor: 2.486
Ranked #31/211 Oncology
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APA
Pérez-Sayáns, M., Somoza-Martín, J.M., Barros-Angueira, F., Reboiras-López, M.D., Gándara Rey, J.M., & García-García, A. (2009). Genetic and molecular alterations associated with oral squamous cell cancer (Review). Oncology Reports, 22, 1277-1282. http://dx.doi.org/10.3892/or_00000565
MLA
Pérez-Sayáns, M., Somoza-Martín, J. M., Barros-Angueira, F., Reboiras-López, M. D., Gándara Rey, J. M., García-García, A."Genetic and molecular alterations associated with oral squamous cell cancer (Review)". Oncology Reports 22.6 (2009): 1277-1282.
Chicago
Pérez-Sayáns, M., Somoza-Martín, J. M., Barros-Angueira, F., Reboiras-López, M. D., Gándara Rey, J. M., García-García, A."Genetic and molecular alterations associated with oral squamous cell cancer (Review)". Oncology Reports 22, no. 6 (2009): 1277-1282. http://dx.doi.org/10.3892/or_00000565