Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production

  • Authors:
    • Kun-Yong Kim
    • Ahmi Baek
    • Yun S. Park
    • Mi Y. Park
    • Jae H. Kim
    • Jong-Seok Lim
    • Myeong-Sok Lee
    • Suk R. Yoon
    • Hee G. Lee
    • Yoosik Yoon
    • Do-Young Yoon
    • Young Yang
  • View Affiliations

  • Published online on: December 1, 2009     https://doi.org/10.3892/or_00000593
  • Pages: 1497-1504
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Abstract

We explored whether adipocyte culture medium affects the secreted chemokine profile of tumor cells, because adipocytes stimulate progression or metastasis of breast cancer cells, and chemokines secreted from tumor cells are involved in these processes. CCL20 expression was dramatically increased, and an NF-κB blocker completely inhibited adipocyte culture medium-induced CCL20 expression in MDA-MB-231 cells. We showed that adipocyte culture medium increased the production of TNF-α in MDA-MB-231 cells, which stimulated CCL20 expression in an autocrine fashion. Our data also showed that CCL20 increased the migration and invasiveness of MDA-MB-231 cells, but did not affect the proliferation of these cells.

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December 2009
Volume 22 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kim K, Baek A, Park YS, Park MY, Kim JH, Lim J, Lee M, Yoon SR, Lee HG, Yoon Y, Yoon Y, et al: Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production . Oncol Rep 22: 1497-1504, 2009
APA
Kim, K., Baek, A., Park, Y.S., Park, M.Y., Kim, J.H., Lim, J. ... Yang, Y. (2009). Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production . Oncology Reports, 22, 1497-1504. https://doi.org/10.3892/or_00000593
MLA
Kim, K., Baek, A., Park, Y. S., Park, M. Y., Kim, J. H., Lim, J., Lee, M., Yoon, S. R., Lee, H. G., Yoon, Y., Yoon, D., Yang, Y."Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production ". Oncology Reports 22.6 (2009): 1497-1504.
Chicago
Kim, K., Baek, A., Park, Y. S., Park, M. Y., Kim, J. H., Lim, J., Lee, M., Yoon, S. R., Lee, H. G., Yoon, Y., Yoon, D., Yang, Y."Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production ". Oncology Reports 22, no. 6 (2009): 1497-1504. https://doi.org/10.3892/or_00000593