HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis

  • Authors:
    • Nobuyuki Bandoh
    • Takeshi Ogino
    • Akihiro Katayama
    • Miki Takahara
    • Akihiro Katada
    • Tatsuya Hayashi
    • Yasuaki Harabuchi
  • View Affiliations

  • Published online on: April 1, 2010     https://doi.org/10.3892/or_00000717
  • Pages: 933-939
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

HLA class I antigen processing machinery plays a crucial role in the generation of peptides from endogeneously synthesized proteins and in their presentation to cytotoxic T lymphocytes. The purpose of this study was to analyze the downregulation of HLA class I antigen, transporter associated with antigen processing (TAP) and tapasin in primary and metastatic lesions of head and neck squamous cell carcinoma (HNSCC) and to compare TAP, tapasin and HLA class I antigen downregulation in metastatic lesions with that of primary lesions. We analyzed expression levels of TAP1, TAP2, tapasin and HLA class I antigen in 25 primary and autologous metastatic lesions by staining formalin-fixed, paraffin-embedded tissue sections in the immunoperoxidase reaction. We identified the expression levels of TAP1, TAP2, tapasin and HLA class I antigen were coordinately downregulated in both primary and metastatic lesions and were significantly lower in metastatic lesions than in autologous primary lesions tested. HLA class I antigen downregulation in metastatic lesion was significantly associated with reduced disease-free survival of patients (P<0.05). Multivariate Cox proportional hazards model analysis identified negativity of HLA class I antigen as an independent prognostic marker. HLA class I antigen and TAP are likely to be downregulated in metastatic lesions compared with primary lesions in HNSCC. The higher frequency of HLA class I antigen and TAP down-regulation in metastases play a role in the clinical course of the disease.

Related Articles

Journal Cover

April 2010
Volume 23 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Bandoh N, Ogino T, Katayama A, Takahara M, Katada A, Hayashi T and Harabuchi Y: HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis . Oncol Rep 23: 933-939, 2010
APA
Bandoh, N., Ogino, T., Katayama, A., Takahara, M., Katada, A., Hayashi, T., & Harabuchi, Y. (2010). HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis . Oncology Reports, 23, 933-939. https://doi.org/10.3892/or_00000717
MLA
Bandoh, N., Ogino, T., Katayama, A., Takahara, M., Katada, A., Hayashi, T., Harabuchi, Y."HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis ". Oncology Reports 23.4 (2010): 933-939.
Chicago
Bandoh, N., Ogino, T., Katayama, A., Takahara, M., Katada, A., Hayashi, T., Harabuchi, Y."HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis ". Oncology Reports 23, no. 4 (2010): 933-939. https://doi.org/10.3892/or_00000717