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Molecular targets for therapeutic interventions in human papillomavirus-related cancers (Review)

  • Authors:
    • Alan Saito Ramalho
    • Anselmo Dantas Lopes
    • Aleylove Talans
    • Bruno Yoshihiro Parlato Sakiyama
    • Guilherme Luiz Stelko Pereira
    • Paulo Marcelo Hoff
    • Gilberto De Castro

  • View Affiliations

  • Published online on: December 1, 2010     https://doi.org/10.3892/or_00001001
  • Pages: 1419-1426
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The infection by the human papillomavirus (HPV) is the origin of several cancers around the world. In some areas of Brazil, cervical carcinoma is still the cancer with the highest incidence among women. After epithelial cell transformation by HPV, several molecular events are observed, resulting in the malignant phenotype. In this review we discuss potential molecular targets for therapeutic interventions in human HPV-related carcinomas, with emphasis on cervical cancer, based on the alterations observed in the signaling transduction pathways caused by HPV infection. With a special attention to tyrosine kinase receptors, and other kinases involved in signal transduction and angiogenesis, these pathological alterations are evaluated as novel targets for anticancer therapies in HPV-related carcinomas.

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Journal Cover

December 2010
Volume 24 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Saito Ramalho A, Dantas Lopes A, Talans A, Parlato Sakiyama BY, Stelko Pereira GL, Hoff PM and De Castro G: Molecular targets for therapeutic interventions in human papillomavirus-related cancers (Review) . Oncol Rep 24: 1419-1426, 2010
APA
Saito Ramalho, A., Dantas Lopes, A., Talans, A., Parlato Sakiyama, B.Y., Stelko Pereira, G.L., Hoff, P.M., & De Castro, G. (2010). Molecular targets for therapeutic interventions in human papillomavirus-related cancers (Review) . Oncology Reports, 24, 1419-1426. https://doi.org/10.3892/or_00001001
MLA
Saito Ramalho, A., Dantas Lopes, A., Talans, A., Parlato Sakiyama, B. Y., Stelko Pereira, G. L., Hoff, P. M., De Castro, G."Molecular targets for therapeutic interventions in human papillomavirus-related cancers (Review) ". Oncology Reports 24.6 (2010): 1419-1426.
Chicago
Saito Ramalho, A., Dantas Lopes, A., Talans, A., Parlato Sakiyama, B. Y., Stelko Pereira, G. L., Hoff, P. M., De Castro, G."Molecular targets for therapeutic interventions in human papillomavirus-related cancers (Review) ". Oncology Reports 24, no. 6 (2010): 1419-1426. https://doi.org/10.3892/or_00001001