IFITM6 expression is increased in macrophages of tumor-bearing mice

  • Authors:
    • Jeong Hye Han
    • Sunyi Lee
    • Yun Sun Park
    • Jeong Su Park
    • Kun-Yong Kim
    • Jong Seok Lim
    • Ki Sook Oh
    • Young Yang
  • View Affiliations

  • Published online on: December 10, 2010     https://doi.org/10.3892/or.2010.1092
  • Pages: 531-536
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Abstract

The family of interferon-induced transmembrane protein (IFITM) genes consists of IFITM1, 2, 3, 5, and 6. They encode cell surface proteins that modulate cell-cell adhesion and cell differentiation. In a previous study, we showed that IFITM1 is involved in the immune escape and metastasis of gastric cancer cells. In this study, we determined the difference in expression of IFITM family genes in tumor-bearing mice. IFITM1 and 6 were found to be significantly increased. IFITM6 gene expression was increased only in the spleen of tumor-bearing mice but not in the bone marrow, lymph node, or thymus. IFITM6 expression was induced in various macrophages, including splenic, thioglycollate-elicited, and bone marrow-derived macrophages, but not in T cells. Lipopolysaccharides (LPS) also increased IFITM6 expression 24 h after administration, and Toll-like receptor 1, 2, 3, 4, and 9 agonists stimulated IFITM6 expression. These findings imply that the increase in IFITM6 expression may be involved in macrophage functions of tumor-bearing mice.

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February 2011
Volume 25 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Han JH, Lee S, Park YS, Park JS, Kim K, Lim JS, Oh KS and Yang Y: IFITM6 expression is increased in macrophages of tumor-bearing mice. Oncol Rep 25: 531-536, 2011
APA
Han, J.H., Lee, S., Park, Y.S., Park, J.S., Kim, K., Lim, J.S. ... Yang, Y. (2011). IFITM6 expression is increased in macrophages of tumor-bearing mice. Oncology Reports, 25, 531-536. https://doi.org/10.3892/or.2010.1092
MLA
Han, J. H., Lee, S., Park, Y. S., Park, J. S., Kim, K., Lim, J. S., Oh, K. S., Yang, Y."IFITM6 expression is increased in macrophages of tumor-bearing mice". Oncology Reports 25.2 (2011): 531-536.
Chicago
Han, J. H., Lee, S., Park, Y. S., Park, J. S., Kim, K., Lim, J. S., Oh, K. S., Yang, Y."IFITM6 expression is increased in macrophages of tumor-bearing mice". Oncology Reports 25, no. 2 (2011): 531-536. https://doi.org/10.3892/or.2010.1092