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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2011 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck

  • Authors:
    • Zhen-Jin Zhao
    • Fa-Yu Liu
    • Peng Li
    • Xue Ding
    • Zhi-Hong Zong
    • Chang-Fu Sun

  • View Affiliations / Copyright

    Affiliations: Department of Orthodontics, School of Stomatology, China Medical University, No. 117. Nanjing Bei Street, Heping District, Shenyang, Liaoning 110002, P.R. China, Department of Oromaxillofacial-Head and Neck Surgery, School of Stomatology, China Medical University, No. 117. Nanjing Bei Street, Heping District, Shenyang, Liaoning 110002, P.R. China
  • Pages: 729-737
    |
    Published online on: December 14, 2010
       https://doi.org/10.3892/or.2010.1109
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Abstract

Metastatic squamous cell carcinoma of the head and neck (SCCHN) has been shown to express chemokine receptor 7 (CCR7), which activates phosphoinositide-3 kinase (PI3K) to promote invasion and survival of SCCHN cells. We hypothesized that Cdc42 might be involved in the CCR7-PI3K pathway. Adhesion assays, migration assays, immunofluorescence staining, Western blotting and immunohistochemical analysis were used to find whether Cdc42 can be activated by CCL19 (the CCR7 ligand) and its role in SCCHN. Results showed that CCL19 induced polarized localization of Cdc42 and actin polymerization in the leading edge of migrating cells. The level of activated membrane-bound Cdc42 was elevated, as measured by the GTPase activity pull-down assay. The increased membrane localization and membrane-bound activity of Cdc42 were abolished by CCR7 and PI3K inhibition, indicating the involvement of Cdc42 in the CCR7-PI3K cascade. Knockdown of Cdc42 by small interfering RNA (siRNA) led to significant reduction in the activation of Rac, filamentous actin (F-actin) accumulation as well as in the migration and invasion induced by CCL19. Taken together, our data indicate the important role played by Cdc42 in CCL19-induced migration and invasion of SCCHN cells.

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Copy and paste a formatted citation
Spandidos Publications style
Zhao Z, Liu F, Li P, Ding X, Zong Z and Sun C: CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck. Oncol Rep 25: 729-737, 2011.
APA
Zhao, Z., Liu, F., Li, P., Ding, X., Zong, Z., & Sun, C. (2011). CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck. Oncology Reports, 25, 729-737. https://doi.org/10.3892/or.2010.1109
MLA
Zhao, Z., Liu, F., Li, P., Ding, X., Zong, Z., Sun, C."CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck". Oncology Reports 25.3 (2011): 729-737.
Chicago
Zhao, Z., Liu, F., Li, P., Ding, X., Zong, Z., Sun, C."CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck". Oncology Reports 25, no. 3 (2011): 729-737. https://doi.org/10.3892/or.2010.1109
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Z, Liu F, Li P, Ding X, Zong Z and Sun C: CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck. Oncol Rep 25: 729-737, 2011.
APA
Zhao, Z., Liu, F., Li, P., Ding, X., Zong, Z., & Sun, C. (2011). CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck. Oncology Reports, 25, 729-737. https://doi.org/10.3892/or.2010.1109
MLA
Zhao, Z., Liu, F., Li, P., Ding, X., Zong, Z., Sun, C."CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck". Oncology Reports 25.3 (2011): 729-737.
Chicago
Zhao, Z., Liu, F., Li, P., Ding, X., Zong, Z., Sun, C."CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck". Oncology Reports 25, no. 3 (2011): 729-737. https://doi.org/10.3892/or.2010.1109
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