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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2012 Volume 27 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest

  • Authors:
    • Seo Ju Kim
    • Ju-Seog Lee
    • Soo Mi Kim

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju 561-180, Republic of Korea, Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
  • Pages: 1669-1673
    |
    Published online on: January 27, 2012
       https://doi.org/10.3892/or.2012.1662
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Abstract

3,3'-Diindolylmethane (DIM), an active metabolite of indole-3-carbinol, is thought to have antitumor effects in experimental animals and induce apoptosis in various cancer cells. However, the biological functions of DIM in human esophageal cancer cells are unknown. Thus, the purpose of this study was to investigate the cytotoxic effects of DIM in human esophageal squamous cell carcinoma (ESCC) cells to elucidate the molecular mechanism of cell death. Three human ESCC cell lines (TT, TE-8 and TE-12) were used to test the response to DIM. MTT, cell cycle and western blot analyses were conducted. DIM significantly inhibited the proliferation of ESCC cells in a dose- and time-dependent manner. The percentage of G1 phase cells increased 48 h after being treated with DIM. DIM also reduced cyclin D1, cyclin E2, cyclin-dependent kinase (CDK) 4 and CDK 6 activities, and increased p15 and p27 levels. Additionally, DIM diminished pro-caspase-9 protein expression levels and induced increased cleaved poly (ADP-ribose) polymerase levels. These results indicate that DIM leads to G1 phase cell cycle arrest and induces apoptosis by activating caspase-9 in ESCC cells.

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Copy and paste a formatted citation
Spandidos Publications style
Kim SJ, Lee J and Kim SM: 3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest. Oncol Rep 27: 1669-1673, 2012.
APA
Kim, S.J., Lee, J., & Kim, S.M. (2012). 3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest. Oncology Reports, 27, 1669-1673. https://doi.org/10.3892/or.2012.1662
MLA
Kim, S. J., Lee, J., Kim, S. M."3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest". Oncology Reports 27.5 (2012): 1669-1673.
Chicago
Kim, S. J., Lee, J., Kim, S. M."3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest". Oncology Reports 27, no. 5 (2012): 1669-1673. https://doi.org/10.3892/or.2012.1662
Copy and paste a formatted citation
x
Spandidos Publications style
Kim SJ, Lee J and Kim SM: 3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest. Oncol Rep 27: 1669-1673, 2012.
APA
Kim, S.J., Lee, J., & Kim, S.M. (2012). 3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest. Oncology Reports, 27, 1669-1673. https://doi.org/10.3892/or.2012.1662
MLA
Kim, S. J., Lee, J., Kim, S. M."3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest". Oncology Reports 27.5 (2012): 1669-1673.
Chicago
Kim, S. J., Lee, J., Kim, S. M."3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest". Oncology Reports 27, no. 5 (2012): 1669-1673. https://doi.org/10.3892/or.2012.1662
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