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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2012 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2012 Volume 27 Issue 6

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Article

The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis

  • Authors:
    • Zhi-Dong Lv
    • Zhao-Chuan Yang
    • Hai-Bo Wang
    • Jian-Guo Li
    • Bin Kong
    • Xin-Gang Wang
    • Xiao-Yi Liu
    • Zhao-He Niu
    • Yu Wang
    • Gang Nie

  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, P.R. China, Department of Child Health Care, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, P.R. China
  • Pages: 1753-1758
    |
    Published online on: March 19, 2012
       https://doi.org/10.3892/or.2012.1735
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Abstract

Peritoneal dissemination is one of the main causes of death in gastric cancer patients. We have previously reported that gastric cancer cells can induce peritoneal apoptosis, lead to damage of peritoneum integrity, and therefore promote peritoneal metastasis. However, the soluble factors secreted by cancer cells to trigger the damaging cascade remain unclear. TGF-β1, a cytokine known for its capacity to induce proliferative and transformative changes of cells is found in significantly higher quantities correlated with peritoneal metastasis and TNM stages of gastric cancer. High levels of TGF-β1 in the subperitoneal milieu may affect the morphology and function of mesothelial cells, so that the resulting environment becomes favorable for peritoneal metastases. We observed apoptosis induced by TGF-β1 in mesothelial cells in peritoneal carcinomatosis. Knockdown of the smad2 gene by siRNA silencing can partially inhibit these effects. TGF-β1 could upregulate the expressions of Bax and suppress Bcl-2 in mesothelial cells. We conclude that TGF-β1 could induce apoptosis of mesothelial cells, which involves the smad2 signaling pathway in peritoneal carcinomatosis. Bcl-2 and Bax may contribute to this phenomenon.

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Copy and paste a formatted citation
Spandidos Publications style
Lv Z, Yang Z, Wang H, Li J, Kong B, Wang X, Liu X, Niu Z, Wang Y, Nie G, Nie G, et al: The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis. Oncol Rep 27: 1753-1758, 2012.
APA
Lv, Z., Yang, Z., Wang, H., Li, J., Kong, B., Wang, X. ... Nie, G. (2012). The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis. Oncology Reports, 27, 1753-1758. https://doi.org/10.3892/or.2012.1735
MLA
Lv, Z., Yang, Z., Wang, H., Li, J., Kong, B., Wang, X., Liu, X., Niu, Z., Wang, Y., Nie, G."The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis". Oncology Reports 27.6 (2012): 1753-1758.
Chicago
Lv, Z., Yang, Z., Wang, H., Li, J., Kong, B., Wang, X., Liu, X., Niu, Z., Wang, Y., Nie, G."The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis". Oncology Reports 27, no. 6 (2012): 1753-1758. https://doi.org/10.3892/or.2012.1735
Copy and paste a formatted citation
x
Spandidos Publications style
Lv Z, Yang Z, Wang H, Li J, Kong B, Wang X, Liu X, Niu Z, Wang Y, Nie G, Nie G, et al: The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis. Oncol Rep 27: 1753-1758, 2012.
APA
Lv, Z., Yang, Z., Wang, H., Li, J., Kong, B., Wang, X. ... Nie, G. (2012). The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis. Oncology Reports, 27, 1753-1758. https://doi.org/10.3892/or.2012.1735
MLA
Lv, Z., Yang, Z., Wang, H., Li, J., Kong, B., Wang, X., Liu, X., Niu, Z., Wang, Y., Nie, G."The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis". Oncology Reports 27.6 (2012): 1753-1758.
Chicago
Lv, Z., Yang, Z., Wang, H., Li, J., Kong, B., Wang, X., Liu, X., Niu, Z., Wang, Y., Nie, G."The cytotoxic effect of TGF-β1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis". Oncology Reports 27, no. 6 (2012): 1753-1758. https://doi.org/10.3892/or.2012.1735
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