microRNA expression profiles in oral squamous cell carcinoma

Soga,Daisuke; Yoshiba,Sayaka; Shiogama,Sunao; Miyazaki,Hiroaki; Kondo,Seiji; Shintani,Satoru

doi:10.3892/or.2013.2488

microRNA expression profiles in oral squamous cell carcinoma

Authors:
- Daisuke Soga
- Sayaka Yoshiba
- Sunao Shiogama
- Hiroaki Miyazaki
- Seiji Kondo
- Satoru Shintani
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Affiliations: Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Ota-ku, Tokyo 145-8515, Japan
Published online on: May 23, 2013 https://doi.org/10.3892/or.2013.2488
Pages: 579-583

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Abstract

microRNAs (miRNAs) are involved in cancer pathogenesis, apoptosis and cell growth, thereby functioning as both tumor suppressors and oncogenes. However, the expression patterns and roles of miRNAs in oral squamous cell carcinoma (OSCC) remain largely unknown. We hypothesized that oral cancer may have a unique miRNA profile, which in turn may play a critical role in oral cancer development, progression, diagnosis and prognosis. We, therefore, investigated the expression profiles of 29 OSCC tumors and 7 normal oral mucosal samples. The miRNA expression patterns in OSCC were examined by TaqMan-based microRNA assays. We were subsequently able to identify the candidates of cancer-related miRNAs through analysis of the miRNA expression profiles. In conclusion, OSCC tissues were shown to have a unique miRNA profile pattern when compared with that in normal tissues. The present study may provide useful information for further investigation of the functional roles of miRNAs in OSCC development, progression, diagnosis and prognosis.

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