Suppression of LPS-induced epithelial-mesenchymal transition by aqueous extracts of Prunella vulgaris through inhibition of the NF-κB/Snail signaling pathway and regulation of EMT-related protein expression

  • Authors:
    • In-Hye Cho
    • Eun Hyang Jang
    • Darong Hong
    • Bom Jung
    • Min-Ju Park
    • Jong-Ho Kim
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  • Published online on: August 21, 2015     https://doi.org/10.3892/or.2015.4218
  • Pages: 2445-2450
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Abstract

Epithelial-mesenchymal transition (EMT) is a pivotal event in the invasion and metastasis of cancer cells. Prunella vulgaris (PV) inhibits the proliferation of various cancer cells; however, its possible role in EMT has not been demonstrated. In the present study, we explored the effect of PV aqueous extract (PVAE), a typical medicine for decoction, on EMT. Lipopolysaccharide (LPS) induced EMT-like phenotype changes in cancer cell lines that enhanced cell migration and invasion. PVAE markedly inhibited these effects and produced accompanying changes in the expression of EMT markers, including decreased expression of N-cadherin and vimentin, and increased expression of β-catenin. We found that PVAE effects on LPS-induced EMT were mediated by inhibition of the NF-κB/Snail signaling pathway. Our findings provide new evidence that PVAE suppresses cancer invasion and migration by inhibiting EMT. Therefore, we suggest that PVAE is an effective dietary chemopreventive agent with antimetastatic activity against malignant tumors.
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October 2015
Volume 34 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Cho, I., Jang, E.H., Hong, D., Jung, B., Park, M., & Kim, J. (2015). Suppression of LPS-induced epithelial-mesenchymal transition by aqueous extracts of Prunella vulgaris through inhibition of the NF-κB/Snail signaling pathway and regulation of EMT-related protein expression. Oncology Reports, 34, 2445-2450. https://doi.org/10.3892/or.2015.4218
MLA
Cho, I., Jang, E. H., Hong, D., Jung, B., Park, M., Kim, J."Suppression of LPS-induced epithelial-mesenchymal transition by aqueous extracts of Prunella vulgaris through inhibition of the NF-κB/Snail signaling pathway and regulation of EMT-related protein expression". Oncology Reports 34.5 (2015): 2445-2450.
Chicago
Cho, I., Jang, E. H., Hong, D., Jung, B., Park, M., Kim, J."Suppression of LPS-induced epithelial-mesenchymal transition by aqueous extracts of Prunella vulgaris through inhibition of the NF-κB/Snail signaling pathway and regulation of EMT-related protein expression". Oncology Reports 34, no. 5 (2015): 2445-2450. https://doi.org/10.3892/or.2015.4218