Open Access

IL-17A-producing T cells are associated with the progression of lung adenocarcinoma

  • Authors:
    • Zhang Bao
    • Guohua Lu
    • Dawei Cui
    • Yinan Yao
    • Guangdie Yang
    • Jianying Zhou
  • View Affiliations

  • Published online on: May 27, 2016     https://doi.org/10.3892/or.2016.4837
  • Pages: 641-650
  • Copyright: © Bao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Accumulating evidence has shown that T cells are crucial in shaping the tumor microenvironment and regulating tumor development. However, the roles of IL-17A‑producing T cells (IL-17A+CD4+ Th17, IL-17A+CD8+ Tc17 and IL-17A+ γδT17 cells) and related cytokines in the progression of lung cancer (LC) remain uncertain. Here, we found that the frequencies of both Th17 and γδT17 cells in the peripheral blood of patients with lung adenocarcinoma (LA) were higher than those in healthy controls (HCs), whereas the frequency of Tc17 cells in the patients with LA was decreased. In addition, the frequencies of circulating Th17 and γδT17 cells, but not Tc17 cells, were positively associated with tumor invasion and metastasis. Furthermore, the major source of IL-17A production was Th17 cells, followed by Tc17 and γδT17 cells, in peripheral blood from patients with LA and HCs; but the percentages of Th17 and γδT17 cells in total intracellular IL-17A+ cells obtained from the patients with LC were higher than those from HCs. Moreover, the protein and corresponding mRNA levels of IL-17A, IL-23, IL-1β, and TGF-β1 were much higher in the patients with LA than those in HCs, and the levels of IL-17A in patients were positively correlated with numbers of both Th17 and γδT17 cells, but not Tc17 cells. Finally, the frequencies of circulating Th17 and γδT17 cells, along with the levels of IL-17A, IL-23, IL-1β, and TGF-β1 were decreased in the patients with LA after tumor resection, whereas the frequency of circulating Tc17 cells was inversely increased in these patients. Our findings indicate that Th17, Tc17, γδT17 cells, and IL-17A-associated cytokines contribute to the development of LA and thus represent promising targets for therapeutic strategies.
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August-2016
Volume 36 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Bao Z, Lu G, Cui D, Yao Y, Yang G and Zhou J: IL-17A-producing T cells are associated with the progression of lung adenocarcinoma. Oncol Rep 36: 641-650, 2016
APA
Bao, Z., Lu, G., Cui, D., Yao, Y., Yang, G., & Zhou, J. (2016). IL-17A-producing T cells are associated with the progression of lung adenocarcinoma. Oncology Reports, 36, 641-650. https://doi.org/10.3892/or.2016.4837
MLA
Bao, Z., Lu, G., Cui, D., Yao, Y., Yang, G., Zhou, J."IL-17A-producing T cells are associated with the progression of lung adenocarcinoma". Oncology Reports 36.2 (2016): 641-650.
Chicago
Bao, Z., Lu, G., Cui, D., Yao, Y., Yang, G., Zhou, J."IL-17A-producing T cells are associated with the progression of lung adenocarcinoma". Oncology Reports 36, no. 2 (2016): 641-650. https://doi.org/10.3892/or.2016.4837