1
|
Hodi FS, O'Day SJ, McDermott DF, Weber RW,
Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel
JC, et al: Improved survival with ipilimumab in patients with
metastatic melanoma. N Engl J Med. 363:711–723. 2010. View Article : Google Scholar : PubMed/NCBI
|
2
|
Hamid O, Robert C, Daud A, Hodi FS, Hwu
WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS, et al:
Safety and tumor responses with lambrolizumab (anti-PD-1) in
melanoma. N Engl J Med. 369:134–144. 2013. View Article : Google Scholar : PubMed/NCBI
|
3
|
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ,
Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, et al:
Safety and activity of anti-PD-L1 antibody in patients with
advanced cancer. N Engl J Med. 366:2455–2465. 2012. View Article : Google Scholar : PubMed/NCBI
|
4
|
Rizvi NA, Hellmann MD, Snyder A, Kvistborg
P, Makarov V, Havel JJ, Lee W, Yuan J, Wong P, Ho TS, et al: Cancer
immunology. Mutational landscape determines sensitivity to PD-1
blockade in non-small cell lung cancer. Science. 348:124–128. 2015.
View Article : Google Scholar : PubMed/NCBI
|
5
|
Sica GL, Choi IH, Zhu G, Tamada K, Wang
SD, Tamura H, Chapoval AI, Flies DB, Bajorath J and Chen L: B7-H4,
a molecule of the B7 family, negatively regulates T cell immunity.
Immunity. 18:849–861. 2003. View Article : Google Scholar : PubMed/NCBI
|
6
|
Prasad DV, Richards S, Mai XM and Dong C:
B7S1, a novel B7 family member that negatively regulates T cell
activation. Immunity. 18:863–873. 2003. View Article : Google Scholar : PubMed/NCBI
|
7
|
Zang X, Loke P, Kim J, Murphy K, Waitz R
and Allison JP: B7x: a widely expressed B7 family member that
inhibits T cell activation. Proc Natl Acad Sci USA.
100:10388–10392. 2003. View Article : Google Scholar : PubMed/NCBI
|
8
|
Chen L: Co-inhibitory molecules of the
B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol.
4:336–347. 2004. View
Article : Google Scholar : PubMed/NCBI
|
9
|
Pardoll DM: The blockade of immune
checkpoints in cancer immunotherapy. Nat Rev Cancer. 12:252–264.
2012. View
Article : Google Scholar : PubMed/NCBI
|
10
|
Choi IH, Zhu G, Sica GL, Strome SE,
Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K and Chen L: Genomic
organization and expression analysis of B7-H4, an immune inhibitory
molecule of the B7 family. J Immunol. 171:4650–4654. 2003.
View Article : Google Scholar : PubMed/NCBI
|
11
|
Jeon H, Vigdorovich V, Garrett-Thomson SC,
Janakiram M, Ramagopal UA, Abadi YM, Lee JS, Scandiuzzi L,
Ohaegbulam KC, Chinai JM, et al: Structure and cancer immunotherapy
of the B7 family member B7x. Cell Reports. 9:1089–1098. 2014.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Krambeck AE, Thompson RH, Dong H, Lohse
CM, Park ES, Kuntz SM, Leibovich BC, Blute ML, Cheville JC and Kwon
ED: B7-H4 expression in renal cell carcinoma and tumor vasculature:
Associations with cancer progression and survival. Proc Natl Acad
Sci USA. 103:10391–10396. 2006. View Article : Google Scholar : PubMed/NCBI
|
13
|
Miyatake T, Tringler B, Liu W, Liu SH,
Papkoff J, Enomoto T, Torkko KC, Dehn DL, Swisher A and Shroyer KR:
B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid
adenocarcinomas and inversely correlated with tumor T-cell
infiltration. Gynecol Oncol. 106:119–127. 2007. View Article : Google Scholar : PubMed/NCBI
|
14
|
Simon I, Zhuo S, Corral L, Diamandis EP,
Sarno MJ, Wolfert RL and Kim NW: B7-h4 is a novel membrane-bound
protein and a candidate serum and tissue biomarker for ovarian
cancer. Cancer Res. 66:1570–1575. 2006. View Article : Google Scholar : PubMed/NCBI
|
15
|
Thompson RH, Zang X, Lohse CM, Leibovich
BC, Slovin SF, Reuter VE, Cheville JC, Blute ML, Russo P, Kwon ED,
et al: Serum-soluble B7x is elevated in renal cell carcinoma
patients and is associated with advanced stage. Cancer Res.
68:6054–6058. 2008. View Article : Google Scholar : PubMed/NCBI
|
16
|
Rahbar R, Lin A, Ghazarian M, Yau HL,
Paramathas S, Lang PA, Schildknecht A, Elford AR, Garcia-Batres C,
Martin B, et al: B7-H4 expression by nonhematopoietic cells in the
tumor microenvironment promotes antitumor immunity. Cancer Immunol
Res. 3:184–195. 2015. View Article : Google Scholar
|
17
|
Zang X, Sullivan PS, Soslow RA, Waitz R,
Reuter VE, Wilton A, Thaler HT, Arul M, Slovin SF, Wei J, et al:
Tumor associated endothelial expression of B7-H3 predicts survival
in ovarian carcinomas. Mod Pathol. 23:1104–1112. 2010. View Article : Google Scholar : PubMed/NCBI
|
18
|
Kryczek I, Zou L, Rodriguez P, Zhu G, Wei
S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, et al: B7-H4
expression identifies a novel suppressive macrophage population in
human ovarian carcinoma. J Exp Med. 203:871–881. 2006. View Article : Google Scholar : PubMed/NCBI
|
19
|
Kryczek I, Wei S, Zhu G, Myers L, Mottram
P, Cheng P, Chen L, Coukos G and Zou W: Relationship between B7-H4,
regulatory T cells, and patient outcome in human ovarian carcinoma.
Cancer Res. 67:8900–8905. 2007. View Article : Google Scholar : PubMed/NCBI
|
20
|
National Cancer Institute: Genotype-Tissue
Expression (GTEx). http://www.gtexportal.org/home.
2015
|
21
|
Broad institute: The Cancer Cell Line
Encyclopedia (CCLE). https://www.broadinstitute.org/ccle/home.
2015
|
22
|
Dangaj D, Lanitis E, Zhao A, Joshi S,
Cheng Y, Sandaltzopoulos R, Ra HJ, Danet-Desnoyers G, Powell DJ Jr
and Scholler N: Novel recombinant human b7-h4 antibodies overcome
tumoral immune escape to potentiate T-cell antitumor responses.
Cancer Res. 73:4820–4829. 2013. View Article : Google Scholar : PubMed/NCBI
|
23
|
Abadi YM, Jeon H, Ohaegbulam KC,
Scandiuzzi L, Ghosh K, Hofmeyer KA, Lee JS, Ray A, Gravekamp C and
Zang X: Host b7x promotes pulmonary metastasis of breast cancer. J
Immunol. 190:3806–3814. 2013. View Article : Google Scholar : PubMed/NCBI
|
24
|
Lee JS, Scandiuzzi L, Ray A, Wei J,
Hofmeyer KA, Abadi YM, Loke P, Lin J, Yuan J, Serreze DV, et al:
B7x in the periphery abrogates pancreas-specific damage mediated by
self-reactive CD8 T cells. J Immunol. 189:4165–4174. 2012.
View Article : Google Scholar : PubMed/NCBI
|
25
|
Workman P, Aboagye EO, Balkwill F, Balmain
A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DAH,
Glennie MJ, et al: Guidelines for the welfare and use of animals in
cancer research. Br J Cancer. 102:1555–1577. 2010. View Article : Google Scholar : PubMed/NCBI
|
26
|
Tringler B, Zhuo S, Pilkington G, Torkko
KC, Singh M, Lucia MS, Heinz DE, Papkoff J and Shroyer KR: B7-h4 is
highly expressed in ductal and lobular breast cancer. Clin Cancer
Res. 11:1842–1848. 2005. View Article : Google Scholar : PubMed/NCBI
|
27
|
Butte MJ, Keir ME, Phamduy TB, Sharpe AH
and Freeman GJ: Programmed death-1 ligand 1 interacts specifically
with the B7-1 costimulatory molecule to inhibit T cell responses.
Immunity. 27:111–122. 2007. View Article : Google Scholar : PubMed/NCBI
|
28
|
Zhang L, Wu H, Lu D, Li G, Sun C, Song H,
Li J, Zhai T, Huang L, Hou C, et al: The costimulatory molecule
B7-H4 promote tumor progression and cell proliferation through
translocating into nucleus. Oncogene. 32:5347–5358. 2013.
View Article : Google Scholar : PubMed/NCBI
|
29
|
Smith JB, Stashwick C and Powell DJ Jr:
B7-H4 as a potential target for immunotherapy for gynecologic
cancers: A closer look. Gynecol Oncol. 134:181–189. 2014.
View Article : Google Scholar : PubMed/NCBI
|
30
|
Pulczynski S, Boesen AM and Jensen OM:
Antibody-induced modulation and intracellular transport of CD10 and
CD19 antigens in human B-cell lines: An immunofluorescence and
immunoelectron microscopy study. Blood. 81:1549–1557.
1993.PubMed/NCBI
|
31
|
Gerber HP, Kung-Sutherland M, Stone I,
Morris-Tilden C, Miyamoto J, McCormick R, Alley SC, Okeley N, Hayes
B, Hernandez-Ilizaliturri FJ, et al: Potent antitumor activity of
the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE
against rituximab-sensitive and -resistant lymphomas. Blood.
113:4352–4361. 2009. View Article : Google Scholar : PubMed/NCBI
|
32
|
Schaffar L, Dallanegra A, Breittmayer JP,
Carrel S and Fehlmann M: Monoclonal antibody internalization and
degradation during modulation of the CD3/T-cell receptor complex.
Cell Immunol. 116:52–59. 1988. View Article : Google Scholar : PubMed/NCBI
|
33
|
Boyer C, Auphan N, Gabert J, Blanc D,
Malissen B and Schmitt-Verhulst AM: Comparison of phosphorylation
and internalization of the antigen receptor/CD3 complex, CD8, and
class I MHC-encoded proteins on T cells. Role of intracytoplasmic
domains analyzed with hybrid CD8/class I molecules. J Immunol.
143:1905–1914. 1989.PubMed/NCBI
|
34
|
He J, Wang Y, Feng J, Zhu X, Lan X, Iyer
AK, Zhang N, Seo Y, VanBrocklin HF and Liu B: Targeting prostate
cancer cells in vivo using a rapidly internalizing novel human
single-chain antibody fragment. J Nucl Med. 51:427–432. 2010.
View Article : Google Scholar : PubMed/NCBI
|
35
|
Willuda J, Kubetzko S, Waibel R, Schubiger
PA, Zangemeister-Wittke U and Plückthun A: Tumor targeting of
mono-, di-, and tetravalent anti-p185HER-2
miniantibodies multimerized by self-associating peptides. J Biol
Chem. 276:14385–14392. 2001.PubMed/NCBI
|
36
|
Deyev SM, Waibel R, Lebedenko EN,
Schubiger AP and Plückthun A: Design of multivalent complexes using
the barnase·barstar module. Nat Biotechnol. 21:1486–1492. 2003.
View Article : Google Scholar : PubMed/NCBI
|
37
|
Pleckaityte M, Mistiniene E, Lasickiene R,
Zvirblis G and Zvirbliene A: Generation of recombinant single-chain
antibodies neutralizing the cytolytic activity of vaginolysin, the
main virulence factor of Gardnerella vaginalis. BMC Biotechnol.
11:1002011. View Article : Google Scholar : PubMed/NCBI
|
38
|
Willuda J, Honegger A, Waibel R, Schubiger
PA, Stahel R, Zangemeister-Wittke U and Plückthun A: High thermal
stability is essential for tumor targeting of antibody fragments:
Engineering of a humanized anti-epithelial glycoprotein-2
(epithelial cell adhesion molecule) single-chain Fv fragment.
Cancer Res. 59:5758–5767. 1999.PubMed/NCBI
|
39
|
Porter DL, Levine BL, Kalos M, Bagg A and
June CH: Chimeric antigen receptor-modified T cells in chronic
lymphoid leukemia. N Engl J Med. 365:725–733. 2011. View Article : Google Scholar : PubMed/NCBI
|
40
|
Bargou R, Leo E, Zugmaier G, Klinger M,
Goebeler M, Knop S, Noppeney R, Viardot A, Hess G, Schuler M, et
al: Tumor regression in cancer patients by very low doses of a T
cell-engaging antibody. Science. 321:974–977. 2008. View Article : Google Scholar : PubMed/NCBI
|
41
|
Richters A, Sherwin RP and Richters V: The
lymphocyte and human lung cancers. Cancer Res. 31:214–222.
1971.PubMed/NCBI
|
42
|
Cohen AB and Cline MJ: The human alveolar
macrophage: Isolation, cultivation in vitro, and studies of
morphologic and functional characteristics. J Clin Invest.
50:1390–1398. 1971. View Article : Google Scholar : PubMed/NCBI
|