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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2016 Volume 36 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Depression accelerates the development of gastric cancer through reactive oxygen species‑activated ABL1 (Review)

Tianhe Huang, Fuling Zhou, Feng Wang‑Johanning, Kejun Nan, Yongchang Wei
Pages: 2435-2443
Published online on: 23 September 2016

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Article Open Access

Use of NRP1, a novel biomarker, along with VEGF-C, VEGFR-3, CCR7 and SEMA3E, to predict lymph node metastasis in squamous cell carcinoma of the tongue

Hani Al‑Shareef, Shin‑Ichiro Hiraoka, Noriaki Tanaka, Yosuke Shogen, Atsushi‑Doksa Lee, Sanam Bakhshishayan, Mikihiko Kogo
Pages: 2444-2454
Published online on: 21 September 2016

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Article Open Access

Gene fusions AHRR-NCOA2, NCOA2-ETV4, ETV4-AHRR, P4HA2-TBCK, and TBCK-P4HA2 resulting from the translocations t(5;8;17)(p15;q13;q21) and t(4;5)(q24;q31) in a soft tissue angiofibroma

Ioannis Panagopoulos, Ludmila Gorunova, Trond Viset, Sverre Heim
Pages: 2455-2462
Published online on: 15 September 2016

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Article Open Access

Silencing MARCH1 suppresses proliferation, migration and invasion of ovarian cancer SKOV3 cells via downregulation of NF-κB and Wnt/β-catenin pathways

Ying Meng, Jianguo Hu, Yuhong Chen, Tinghe Yu, Lina Hu
Pages: 2463-2470
Published online on: 08 September 2016

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Article Open Access

Heparin regulates B6FS cell motility through a FAK/actin cytoskeleton axis

Kallirroi Voudouri, Dragana Nikitovic, Aikaterini Berdiaki, Dionysios J. Papachristou, John Tsiaoussis, Demetrios A. Spandidos, Aristides M. Tsatsakis, George N. Tzanakakis
Pages: 2471-2480
Published online on: 30 August 2016

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Case Report Open Access

RUNX1 truncation resulting from a cryptic and novel t(6;21)(q25;q22) chromosome translocation in acute myeloid leukemia: A case report

Ioannis Panagopoulos, Synne Torkildsen, Ludmila Gorunova, Aina Ulvmoen, Anne Tierens, Bernward Zeller, Sverre Heim
Pages: 2481-2488
Published online on: 22 September 2016

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Article Open Access

Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker

Lahong Zhang, Zhaojun Chen, Dan Xue, Qi Zhang, Xiyong Liu, Frank Luh, Liquan Hong, Hang Zhang, Feng Pan, Yuhua Liu, Peiguo Chu, Shu Zheng, Guoqiang Lou, Yun Yen
Pages: 2489-2500
Published online on: 20 September 2016

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Article Open Access

Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears

Sergei E. Titov, Pavel S. Demenkov, Mikhail K. Ivanov, Ekaterina S. Malakhina, Tatiana L. Poloz, Elena V. Tsivlikova, Maria S. Ganzha, Sergei P. Shevchenko, Lyudmila F. Gulyaeva, Nikolay N. Kolesnikov
Pages: 2501-2510
Published online on: 20 September 2016

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Article Open Access

MicroRNA-101 regulates T-cell acute lymphoblastic leukemia progression and chemotherapeutic sensitivity by targeting Notch1

Lu Qian, Wanggang Zhang, Bo Lei, Aili He, Lianhong Ye, Xingzhou Li, Xin Dong
Pages: 2511-2516
Published online on: 21 September 2016

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Article Open Access

Differential expression of CCN family members CYR611, CTGF and NOV in gastric cancer and their association with disease progression

Jun Li, Xiangyu Gao, Ke Ji, Andrew J. Sanders, Zhongtao Zhang, Wen G. Jiang, Jiafu Ji, Lin Ye
Pages: 2517-2525
Published online on: 08 September 2016

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Article Open Access

13-Methyl-palmatrubine induces apoptosis and cell cycle arrest in A549 cells in vitro and in vivo

Jingxian Chen, Xingang Lu, Chenghua Lu, Chunying Wang, Haizhu Xu, Xiaoli Xu, Haixin Gou, Bing Zhu, Wangchun Du
Pages: 2526-2534
Published online on: 15 September 2016

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Article Open Access

Quantification of plasma exosome is a potential prognostic marker for esophageal squamous cell carcinoma

Yasunori Matsumoto, Masayuki Kano, Yasunori Akutsu, Naoyuki Hanari, Isamu Hoshino, Kentaro Murakami, Akihiro Usui, Hiroshi Suito, Masahiko Takahashi, Ryota Otsuka, Hu Xin, Aki Komatsu, Keiko Iida, Hisahiro Matsubara
Pages: 2535-2543
Published online on: 05 September 2016

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Article Open Access

Combination of lentivirus-mediated silencing of PPM1D and temozolomide chemotherapy eradicates malignant glioma through cell apoptosis and cell cycle arrest

Peng Wang, Jing-An Ye, Chong-Xian Hou, Dong Zhou, Sheng-Quan Zhan
Pages: 2544-2552
Published online on: 14 September 2016

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Article

MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma

Yun Yang, Jin Zhang, Tian Xia, Gaiyun Li, Tao Tian, Mengchao Wang, Ruoyu Wang, Linghao Zhao, Yuan Yang, Ke Lan, Weiping Zhou
Pages: 2553-2562
Published online on: 23 September 2016

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Article

MicroRNA-127-3p acts as a tumor suppressor in epithelial ovarian cancer by regulating the BAG5 gene

Linlin Bi, Qian Yang, Jiani Yuan, Qing Miao, Linrui Duan, Feng Li, Siwang Wang
Pages: 2563-2570
Published online on: 29 August 2016

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Article

Long non-coding RNA expression profile in vulvar squamous cell carcinoma and its clinical significance

Sha Ni, Xiaoyu Zhao, Ling Ouyang
Pages: 2571-2578
Published online on: 08 September 2016

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Article

Upregulation and activation of δ‑opioid receptors promotes the progression of human breast cancer

Yang‑Chao Wei, Bin Zhang, Xuan Li, Xiao‑Meng Liu, Jing Zhang, Biao Lei, Bo Li, Run Zhai, Qian Chen, Yang Li
Pages: 2579-2586
Published online on: 19 September 2016

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Article

Downregulated expression of miRNA-149 promotes apoptosis in side population cells sorted from the TSU prostate cancer cell line

Yatong Chen, Jiahui Zhao, Yong Luo, Yongxing Wang, Yongguang Jiang
Pages: 2587-2600
Published online on: 25 August 2016

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Article

RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer

Bo Ram Kim, Myoung Hee Kang, Jung Lim Kim, Yoo Jin Na, Seong Hye Park, Sun Il Lee, Sanghee Kang, Sung Yup Joung, Suk-Young Lee, Dae‑Hee Lee, Byung Wook Min, Sang Cheul Oh
Pages: 2601-2608
Published online on: 12 September 2016

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Article

MicroRNA‑187 is an independent prognostic factor in lung cancer and promotes lung cancer cell invasion via targeting of PTRF

Jie Peng, Hong‑Zhou Liu, Jun Zhong, Zhuo‑Feng Deng, Chao‑Rong Tie, Qian Rao, Wei Xu, Tao You, Jing Li, Chuan‑Bao Cai, Qian Lu, Wei Liu, Yan Zhang, Zhi‑Yun Lei
Pages: 2609-2618
Published online on: 12 September 2016

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Article

Long non-coding RNAs and genes contributing to the generation of cancer stem cells in hepatocellular carcinoma identified by RNA sequencing analysis

Liye Cao, Quan Zhang, Shujie Cheng, Zhi Chen, Zhijuan Hua, Jihong Yang, Dan Liu, Na Cui
Pages: 2619-2624
Published online on: 22 September 2016

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Article

Unstable B7-H4 cell surface expression and T-cell redirection as a means of cancer therapy

Akira Iizuka, Ryota Kondou, Chizu Nonomura, Tadashi Ashizawa, Keiichi Ohshima, Masatoshi Kusuhara, Mitsuhiro Isaka, Yasuhisa Ohde, Ken Yamaguchi, Yasuto Akiyama
Pages: 2625-2632
Published online on: 12 September 2016

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Article

MPS1 kinase as a potential therapeutic target in medulloblastoma

Irina Alimova, June Ng, Peter Harris, Diane Birks, Andrew Donson, Michael D. Taylor, Nicholas K. Foreman, Sujatha Venkataraman, Rajeev Vibhakar
Pages: 2633-2640
Published online on: 12 September 2016

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Article

AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells

Sang-Yoon Park, Minji Choi, Dain Park, Minho Jeong, Kwang Seok Ahn, Junhee Lee, Paul B. Fisher, Miyong Yun, Seok-Geun Lee
Pages: 2641-2646
Published online on: 19 September 2016

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Article

Rapamycin and fructose-1,6-bisphosphate reduce the HEPG2 cell proliferation via increase of free radicals and apoptosis

Elisa Feller Gonçalves da Silva, Gabriele Catyana Krause, Kelly Goulart Lima, Gabriela Viegas Haute, Leonardo Pedrazza, Fernanda Cristina Mesquita, Bruno Souza Basso, Anderson Catarina Velasquez, Fernanda Bordignon Nunes, Jarbas Rodrigues de Oliveira
Pages: 2647-2652
Published online on: 20 September 2016

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Article Open Access

Upregulation of INS-IGF2 read-through expression and identification of a novel INS-IGF2 splice variant in insulinomas

Lene E. Johannessen, Ioannis Panagopoulos, Sven-Petter Haugvik, Ivar Prydz Gladhaug, Sverre Heim, Francesca Micci
Pages: 2653-2662
Published online on: 23 September 2016

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Article

Liver resection for intrahepatic cholangiocarcinoma in AJCC‑stage Ⅳ: An evaluation of the survival benefit and prognostic accuracy of current AJCC staging system on N and M classification

Lei Yuan, Xianwu Luo, Xinyuan Lu, Bin Huang, Quanyu Cai
Pages: 2663-2672
Published online on: 19 September 2016

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Article

lncRNA-SNHG7 promotes the proliferation, migration and invasion and inhibits apoptosis of lung cancer cells by enhancing the FAIM2 expression

Kelin She, Jun Huang, Huaping Zhou, Tonghai Huang, Guojun Chen, Jianxing He
Pages: 2673-2680
Published online on: 19 September 2016

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Article

NMMHC-IIA-dependent nuclear location of CXCR4 promotes migration and invasion in renal cell carcinoma

Zhipeng Xu, Peng Li, Dan Wei, Zhixiang Wang, Yi Bao, Jipeng Sun, Le Qu, Linhui Wang
Pages: 2681-2688
Published online on: 12 September 2016

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Article

HER2-targeted recombinant protein immuno-caspase-6 effectively induces apoptosis in HER2-overexpressing GBM cells in vitro and in vivo

Leiming Zhang, Junlin Ren, Hangyu Zhang, Gang Cheng, Yanming Xu, Shuangwu Yang, Chao Dong, Dandong Fang, Jianning Zhang, Angang Yang
Pages: 2689-2696
Published online on: 12 September 2016

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Article

CYR61 suppresses growth of human malignant melanoma

Jun Chen, Yang Liu, Qilin Sun, Beiqing Wang, Ningli Li, Xiangdong Chen
Pages: 2697-2704
Published online on: 23 September 2016

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Article

Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer

Chao Huang, Hong Liu, Xiu-Li Gong, Liyun Wu, Bin Wen
Pages: 2705-2714
Published online on: 19 September 2016

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Article

Heme oxygenase-1 retards hepatocellular carcinoma progression through the microRNA pathway

Chaoxia Zou, Chendan Zou, Wanpeng Cheng, Qiang Li, Zhongjing Han, Xiaona Wang, Jianfeng Jin, Jiaqi Zou, Zhiyan Liu, Zhongqiu Zhou, Weiming Zhao, Zhimin Du
Pages: 2715-2722
Published online on: 30 August 2016

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Article

Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways

Xuan Zhou, Xiaoming Xing, Shuping Zhang, Lili Liu, Chengqin Wang, Lin Li, Qiuxia Ji, Huamin Liu
Pages: 2723-2730
Published online on: 16 September 2016

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Article

AZT exerts its antitumoral effect by telomeric and non-telomeric effects in a mammary adenocarcinoma model

Romina G. Armando, Diego Mengual Gomez, Daniel E. Gomez
Pages: 2731-2736
Published online on: 15 September 2016

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Article

Hypermethylation and downregulation of glutathione peroxidase 3 are related to pathogenesis of melanoma

Haiyue Chen, Zhenlong Zheng, Ki-Yeol Kim, Xuemei Jin, Mi Ryung Roh, Zhehu Jin
Pages: 2737-2744
Published online on: 05 September 2016

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Article

Periostin expression in cancer-associated fibroblasts of invasive ductal breast carcinoma

Katarzyna Ratajczak-Wielgomas, Jedrzej Grzegrzolka, Aleksandra Piotrowska, Agnieszka Gomulkiewicz, Wojciech Witkiewicz, Piotr Dziegiel
Pages: 2745-2754
Published online on: 15 September 2016

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Article

CYP24A1-induced vitamin D insufficiency promotes breast cancer growth

Makoto Osanai, Gang-Hong Lee
Pages: 2755-2762
Published online on: 05 September 2016

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Article

An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells

Meng-Li Gu, Ya-Mei Wang, Xin-Xin Zhou, Hang-Ping Yao, Song Zheng, Zun Xiang, Feng Ji
Pages: 2763-2770
Published online on: 12 September 2016

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Article

Baicalein inhibits TNF-α-induced NF-κB activation and expression of NF-κB-regulated target gene products

Junbo Li, Juan Ma, Ke Si Wang, Chunliu Mi, Zhe Wang, Lian Xun Piao, Guang Hua Xu, Xuezheng Li, Jung Joon Lee, Xuejun Jin
Pages: 2771-2776
Published online on: 19 September 2016

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Article

RUNX2 promotes hepatocellular carcinoma cell migration and invasion by upregulating MMP9 expression

Qian Wang, Wei Yu, Tao Huang, Yan Zhu, Changshan Huang
Pages: 2777-2784
Published online on: 19 September 2016

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Article

Anti-proliferation effects of trifolirhizin on MKN45 cells and possible mechanism

Xingang Lu, Jianxia Ma, Hongfu Qiu, Liu Yang, Lei Cao, Jie Shen
Pages: 2785-2792
Published online on: 23 September 2016

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Article

RNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growth

Feng Yan, Xiaoming Wang, Mingchen Zhu, Xiaoya Hu
Pages: 2793-2799
Published online on: 23 September 2016

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Article

UII/GPR14 is involved in NF-κB-mediated colonic inflammation in vivo and in vitro

Yi Yang, Jinpei Zhang, Xi Chen, Tao Wu, Xin Xu, Gang Cao, Hua Li, Yiming Li
Pages: 2800-2806
Published online on: 05 September 2016

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Article

Eupalinolide O, a novel sesquiterpene lactone from Eupatorium lindleyanum DC., induces cell cycle arrest and apoptosis in human MDA-MB-468 breast cancer cells

Bo Yang, Yaping Zhao, Chenghua Lou, Huajun Zhao
Pages: 2807-2813
Published online on: 21 September 2016

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Article

Effect of metastasis suppressor 1 on H1299 cells and its clinical significance in non-small cell lung cancer

Heyan Zhao, Jianhua Xue, Junhua Liu, Yifei Liu, Yinan Cheng
Pages: 2814-2822
Published online on: 12 September 2016

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Article

Mismatch repair gene mutation spectrum in the Swedish Lynch syndrome population

Kristina Lagerstedt-Robinson, Anna Rohlin, Christos Aravidis, Beatrice Melin, Margareta Nordling, Marie Stenmark-Askmalm, Annika Lindblom, Mef Nilbert
Pages: 2823-2835
Published online on: 01 September 2016

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Article

Angiogenin elevates the invasive potential of squamous cell lung carcinoma cells through epithelial‑mesenchymal transition

Li Xu, Yan Yan, Xiang Xue, Chun-Guang Li, Zhi-Yun Xu, He-Zhong Chen
Pages: 2836-2842
Published online on: 19 September 2016

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Article

Enhanced anti-tumor immunity against breast cancer induced by whole tumor cell vaccines genetically modified expressing α-Gal epitopes

Dabing Xue, Ying Liang, Siliang Duan, Jian He, Jing Su, Jianmeng Zhu, Nan Hu, Jianming Liu, Yongxiang Zhao, Xiaoling Lu
Pages: 2843-2851
Published online on: 23 September 2016

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Article

Clinical significance of CD44 variant 9 expression as a prognostic indicator in bladder cancer

Keita Kobayashi, Hiroaki Matsumoto, Hideyasu Matsuyama, Nakanori Fujii, Ryo Inoue, Yoshiaki Yamamoto, Kazuhiro Nagao
Pages: 2852-2860
Published online on: 01 September 2016

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Article

Melatonin induces cell apoptosis in Mia PaCa-2 cells via the suppression of nuclear factor-κB and activation of ERK and JNK: A novel therapeutic implication for pancreatic cancer

Weimin Li, Jiansheng Wu, Zhiyin Li, Zhibo Zhou, Chao Zheng, Le Lin, Binbin Tan, Min Huang, Mengdi Fan
Pages: 2861-2867
Published online on: 16 September 2016

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Article

WP1066 exhibits antitumor efficacy in nasal‑type natural killer/T-cell lymphoma cells through downregulation of the STAT3 signaling pathway

Lingyun Geng, Xinyu Li, Xiangxiang Zhou, Xiaosheng Fang, Dai Yuan, Xin Wang
Pages: 2868-2874
Published online on: 15 September 2016

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Article

Antitumor effects of herbal mixture extract in the pancreatic adenocarcinoma cell line PANC1

Pyo June Pak, Beob Hwa Kang, Sung Hyo Park, Ji Hyun Sung, Yong Hoon Joo, Seung Hyun Jung, Namhyun Chung
Pages: 2875-2883
Published online on: 05 September 2016

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Article

MicroRNAs modulate the expression of the SOX18 transcript in lung squamous cell carcinoma

Mateusz Olbromski, Jedrzej Grzegrzolka, Alina Jankowska‑Konsur, Wojciech Witkiewicz, Marzena Podhorska‑Okolow, Piotr Dziegiel
Pages: 2884-2892
Published online on: 19 September 2016

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Article

Association between high levels of Notch3 expression and high invasion and poor overall survival rates in pancreatic ductal adenocarcinoma

Jin-Xue Zhou, Liang Zhou, Qing-Jun Li, Wen Feng, Pei-Min Wang, Er-Feng Li, Wen-Jing Gong, Ming-Wen Kou, Wei-Ting Gou, Yan-Ling Yang
Pages: 2893-2901
Published online on: 09 September 2016

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Article

Anti-hepatic fibrosis effects of a novel turtle shell decoction by inhibiting hepatic stellate cell proliferation and blocking TGF-β1/Smad signaling pathway in rats

Ganping Bai, Guohe Yan, Guojian Wang, Ping Wan, Ronghua Zhang
Pages: 2902-2910
Published online on: 09 September 2016

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Article

Identification and functional characterization of lncRNAs acting as ceRNA involved in the malignant progression of glioblastoma multiforme

Kun Zhang, Qi Li, Xixiong Kang, Yajie Wang, Shuo Wang
Pages: 2911-2925
Published online on: 05 September 2016

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Article

Effect of PPM1H on malignant phenotype of human pancreatic cancer cells

Han Zhu, Hua Qin, De-Min Li, Jing Liu, Qiu Zhao
Pages: 2926-2934
Published online on: 05 September 2016

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Article

Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway

Lei Yi, Yan Cui, Qingfu Xu, Yugang Jiang
Pages: 2935-2945
Published online on: 16 September 2016

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Article

MicroRNA miR-374, a potential radiosensitizer for carbon ion beam radiotherapy

Sung-Jae Baek, Katsutoshi Sato, Naohiro Nishida, Jun Koseki, Rikako Azuma, Koichi Kawamoto, Masamitsu Konno, Kazuhiko Hayashi, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii, Kazuhiko Ogawa
Pages: 2946-2950
Published online on: 22 September 2016

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Article

In vitro and in vivo activities of an antitumor peptide HM-3: A special dose-efficacy relationship on an HCT‑116 xenograft model in nude mice Corrigendum in /10.3892/or.2020.7503

Sitelbanat Yassin, Jialiang Hu, Hanmei Xu, Ce Li, Sarra Setrerrahmane
Pages: 2951-2959
Published online on: 09 September 2016

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Article

lncRNA-UCA1 enhances cell proliferation through functioning as a ceRNA of Sox4 in esophageal cancer

Changjie Jiao, Zhiming Song, Jianming Chen, Jing Zhong, Weibin Cai, Suke Tian, Songlin Chen, Yunfeng Yi, Yun Xiao
Pages: 2960-2966
Published online on: 22 September 2016

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Article

Let-7g-5p inhibits epithelial-mesenchymal transition consistent with reduction of glioma stem cell phenotypes by targeting VSIG4 in glioblastoma

Xin-Hua Zhang, Yun Qian, Zheng Li, Ning-Ning Zhang, Yun-Jie Xie
Pages: 2967-2975
Published online on: 16 September 2016

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Article

Association of pleural effusion with an early molecular response in patients with newly diagnosed chronic-phase chronic myeloid leukemia receiving dasatinib: Results of a D-First study

Maki Hagihara, Noriyoshi Iriyama, Chikashi Yoshida, Hisashi Wakita, Shigeru Chiba, Shinichiro Okamoto, Kimihiro Kawakami, Naoki Takezako, Takashi Kumagai, Koiti Inokuchi, Kazuma Ohyashiki, Jun Taguchi, Shingo Yano, Tadahiko Igarashi, Yasuji Kouzai, Satoshi Morita, Junichi Sakamoto, Hisashi Sakamaki
Pages: 2976-2982
Published online on: 20 September 2016

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Article

GPRC5A exerts its tumor-suppressive effects in breast cancer cells by inhibiting EGFR and its downstream pathway

Lu Yang, Tao Ma, Jin Zhang
Pages: 2983-2990
Published online on: 02 September 2016

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Article

Inhibition of Nox1 induces apoptosis by attenuating the AKT signaling pathway in oral squamous cell carcinoma cell lines

Kunihiro Ito, Akinobu Ota, Takayuki Ono, Toshiki Nakaoka, Md. Wahiduzzaman, Sivasundaram Karnan, Hiroyuki Konishi, Akifumi Furuhashi, Tomio Hayashi, Yoichi Yamada, Yoshitaka Hosokawa, Yoshiaki Kazaoka
Pages: 2991-2998
Published online on: 05 September 2016

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Article

Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells

Wan-Hu Fan, Fen-Jing Du, Xiao-Jing Liu, Na Chen
Pages: 2999-3004
Published online on: 23 September 2016

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Article

Elucidation of the molecular mechanisms of anaplastic thyroid carcinoma by integrated miRNA and mRNA analysis

Guoping Liu, Kainan Wu, Yuan Sheng
Pages: 3005-3013
Published online on: 05 September 2016

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Article

Aliskiren targets multiple systems to alleviate cancer cachexia

Chaoyi Wang, Dunwei Guo, Qiang Wang, Song You, Zhongpeng Qiao, Yong Liu, Hang Dai, Hua Tang
Pages: 3014-3022
Published online on: 21 September 2016

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Article

MicroRNA-330-5p negatively regulates ITGA5 expression in human colorectal cancer

Hye-In Yoo, Bong-Kyu Kim, Sungjoo Kim Yoon
Pages: 3023-3029
Published online on: 15 September 2016

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Article

Establishment and characterization of an expanding-type gastric cancer cell line by Ming's classification

Hao Xu, Ji-Gui Peng, Yi-Fan Zhuang, Jia-Jia Chen, Qi-Cong Luo, Wei-Feng Huang, Chun-Dong Lin, Jian-Chun Cai
Pages: 3030-3036
Published online on: 14 September 2016

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Article

Growth inhibitory and apoptosis-inducing effects of allergen-free Rhus verniciflua Stokes extract on A549 human lung cancer cells

Ik-Soon Jang, Jae-Woo Park, Eun-Bi Jo, Chong-Kwan Cho, Yeon-Weol Lee, Hwa‑Seung Yoo, Junsoo Park, Jihye Kim, Byeong-Churl Jang, Jong-Soon Choi
Pages: 3037-3043
Published online on: 23 September 2016

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Article

FoxO3a mediates glioma cell invasion by regulating MMP9 expression

Ke Xu, Hua Pei, Zhenhao Zhang, Sufang Dong, Rui-Jia Fu, Wen-Ming Wang, Huamin Wang
Pages: 3044-3050
Published online on: 12 September 2016

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Article

MicroRNA-3666-induced suppression of SIRT7 inhibits the growth of non-small cell lung cancer cells

Hongyang Shi, Yuqiang Ji, Dexin Zhang, Yun Liu, Ping Fang
Pages: 3051-3057
Published online on: 05 September 2016

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Article

Lapatinib-resistant cancer cells possessing epithelial cancer stem cell properties develop sensitivity during sphere formation by activation of the ErbB/AKT/cyclin D2 pathway

Yuichi Ohnishi, Hiroki Yasui, Kenji Kakudo, Masami Nozaki
Pages: 3058-3064
Published online on: 07 September 2016

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Article

Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro

Silvio Holzner, Daniel Senfter, Serena Stadler, Anna Staribacher, Chi Huu Nguyen, Anna Gaggl, Silvana Geleff, Nicole Huttary, Sigurd Krieger, Walter Jäger, Helmut Dolznig, Robert M. Mader, Georg Krupitza
Pages: 3065-3071
Published online on: 20 September 2016

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Article

Staurosporine enhances ATRA-induced granulocytic differentiation in human leukemia U937 cells via the MEK/ERK signaling pathway

Lei Shi, Xiang-Qin Weng, Yan Sheng, Jing Wu, Ming Ding, Xun Cai
Pages: 3072-3080
Published online on: 23 September 2016

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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