Association between high levels of Notch3 expression and high invasion and poor overall survival rates in pancreatic ductal adenocarcinoma

  • Authors:
    • Jin-Xue Zhou
    • Liang Zhou
    • Qing-Jun Li
    • Wen Feng
    • Pei-Min Wang
    • Er-Feng Li
    • Wen-Jing Gong
    • Ming-Wen Kou
    • Wei-Ting Gou
    • Yan-Ling Yang
  • View Affiliations

  • Published online on: September 9, 2016     https://doi.org/10.3892/or.2016.5079
  • Pages: 2893-2901
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a commonly fatal tumour. It is characterized by early metastasis and high mortality. Many patients die as a result of PDAC tumour progression. However, the underlying mechanism of invasion and metastasis in PDAC is still not fully understood. Previous studies showed that the Notch signalling pathway may play an important role in the progression of tumour invasion and metastasis. However, it is not yet known whether the Notch signalling pathway participates in the progression of invasion in PDAC. In the present study, immunohistochemistry showed that a high expression of Notch3 was correlated with tumour grade, metastasis, venous invasion and American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) stage. Kaplan-Meier curves suggested that a high expression of Notch3 was a significant risk factor for shortened survival time. We also showed that inhibition of Notch3 had an anti‑invasion role in PDAC cells. In vitro, the inhibition of Notch3 reduced the migration and invasion capabilities of PDAC cells by regulating the expressions of E-cadherin, CD44v6, MMP-2, MMP-9, VEGF and uPA via regulating the COX-2 and ERK1/2 pathways. These results indicated that downregulation of the Notch signalling pathway may be a novel and useful approach for preventing and treating PDAC invasion.
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November-2016
Volume 36 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhou J, Zhou L, Li Q, Feng W, Wang P, Li E, Gong W, Kou M, Gou W, Yang Y, Yang Y, et al: Association between high levels of Notch3 expression and high invasion and poor overall survival rates in pancreatic ductal adenocarcinoma. Oncol Rep 36: 2893-2901, 2016
APA
Zhou, J., Zhou, L., Li, Q., Feng, W., Wang, P., Li, E. ... Yang, Y. (2016). Association between high levels of Notch3 expression and high invasion and poor overall survival rates in pancreatic ductal adenocarcinoma. Oncology Reports, 36, 2893-2901. https://doi.org/10.3892/or.2016.5079
MLA
Zhou, J., Zhou, L., Li, Q., Feng, W., Wang, P., Li, E., Gong, W., Kou, M., Gou, W., Yang, Y."Association between high levels of Notch3 expression and high invasion and poor overall survival rates in pancreatic ductal adenocarcinoma". Oncology Reports 36.5 (2016): 2893-2901.
Chicago
Zhou, J., Zhou, L., Li, Q., Feng, W., Wang, P., Li, E., Gong, W., Kou, M., Gou, W., Yang, Y."Association between high levels of Notch3 expression and high invasion and poor overall survival rates in pancreatic ductal adenocarcinoma". Oncology Reports 36, no. 5 (2016): 2893-2901. https://doi.org/10.3892/or.2016.5079