Upregulated CTHRC1 promotes human epithelial ovarian cancer invasion through activating EGFR signaling

  • Authors:
    • Jun Ye
    • Wei Chen
    • Zhi-Yong Wu
    • Jin-Hui Zhang
    • He Fei
    • Li-Wen Zhang
    • Ya-Hui Wang
    • Ya-Ping Chen
    • Xiao-Mei Yang
  • View Affiliations

  • Published online on: October 24, 2016     https://doi.org/10.3892/or.2016.5198
  • Pages: 3588-3596
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Abstract

Epithelial ovarian cancer (EOC) is the major cause of deaths from gynecologic malignancies, and metastasis is the main cause of cancer related death. Collagen triple helix repeat containing-1 (CTHRC1) is a secreted protein that has the ability to inhibit collagen matrix synthesis. In this study, we found that high CTHRC1 expression was associated with poor prognosis of EOC. In vitro experiments showed that CTHRC1 promoted migration and invasion of ovarian cancer cells. CTHRC1 had no effect on ovarian cancer cells viability. Additionally, EGFR inhibitors reduced the promotion effects of CTHRC1 on EOC cell invasion. After silencing of CTHRC1, downregulated expression of phosphorylation of EGFR/ERK1/2/AKT was observed in ovarian cancer cells. Taken together, our results suggest a role for CTHRC1 in the progression of ovarian cancer and identified CTHRC1 as a potentially important predictor for human ovarian cancer prognosis.
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December 2016
Volume 36 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Ye, J., Chen, W., Wu, Z., Zhang, J., Fei, H., Zhang, L. ... Yang, X. (2016). Upregulated CTHRC1 promotes human epithelial ovarian cancer invasion through activating EGFR signaling. Oncology Reports, 36, 3588-3596. https://doi.org/10.3892/or.2016.5198
MLA
Ye, J., Chen, W., Wu, Z., Zhang, J., Fei, H., Zhang, L., Wang, Y., Chen, Y., Yang, X."Upregulated CTHRC1 promotes human epithelial ovarian cancer invasion through activating EGFR signaling". Oncology Reports 36.6 (2016): 3588-3596.
Chicago
Ye, J., Chen, W., Wu, Z., Zhang, J., Fei, H., Zhang, L., Wang, Y., Chen, Y., Yang, X."Upregulated CTHRC1 promotes human epithelial ovarian cancer invasion through activating EGFR signaling". Oncology Reports 36, no. 6 (2016): 3588-3596. https://doi.org/10.3892/or.2016.5198