miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression

  • Authors:
    • Senmao Li
    • Chenghe Wang
    • Xiao Yu
    • Huanlei Wu
    • Jia Hu
    • Shaogang Wang
    • Zhangqun Ye
  • View Affiliations

  • Published online on: November 16, 2016     https://doi.org/10.3892/or.2016.5250
  • Pages: 241-248
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Abstract

Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal controls. Moreover, overexpression of miR-3619-5p readily induced CDKN1A gene expression by directly targeting the putative site in the promoter. Besides, miR-3619-5p possessed considerable capacity to inhibit prostate cancer DU145 and PC3 cell growth, and downregulate several CDKN1A downstream genes, such as cyclin D1, CDK4 and CDK6. Notably, this antitumor function of miR-3619-5p was mainly achieved by stimulating CDKN1A expression.
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January-2017
Volume 37 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Li S, Wang C, Yu X, Wu H, Hu J, Wang S and Ye Z: miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression. Oncol Rep 37: 241-248, 2017
APA
Li, S., Wang, C., Yu, X., Wu, H., Hu, J., Wang, S., & Ye, Z. (2017). miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression. Oncology Reports, 37, 241-248. https://doi.org/10.3892/or.2016.5250
MLA
Li, S., Wang, C., Yu, X., Wu, H., Hu, J., Wang, S., Ye, Z."miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression". Oncology Reports 37.1 (2017): 241-248.
Chicago
Li, S., Wang, C., Yu, X., Wu, H., Hu, J., Wang, S., Ye, Z."miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression". Oncology Reports 37, no. 1 (2017): 241-248. https://doi.org/10.3892/or.2016.5250