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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January-2017 Volume 37 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Non-coding RNAs as regulators in epigenetics (Review)

Jian-Wei Wei, Kai Huang, Chao Yang, Chun-Sheng Kang
Pages: 3-9
Published online on: 08 November 2016

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Article Open Access

A blood-based gene expression and signaling pathway analysis to differentiate between high and low grade gliomas

Stephen N. Ponnampalam, Nor Rizan Kamaluddin, Zubaidah Zakaria, Vickneswaran Matheneswaran, Dharmendra Ganesan, Mohammed Saffari Haspani, Mina Ryten, John A. Hardy
Pages: 10-22
Published online on: 29 November 2016

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Article Open Access

MicroRNA-6826 and -6875 in plasma are valuable non‑invasive biomarkers that predict the efficacy of vaccine treatment against metastatic colorectal cancer

Taiki Kijima, Shoichi Hazama, Ryouichi Tsunedomi, Hironori Tanaka, Hiroko Takenouchi, Shinsuke Kanekiyo, Yuka Inoue, Masao Nakashima, Michihisa Iida, Kazuhiko Sakamoto, Nobuaki Suzuki, Shigeru Takeda, Tomio Ueno, Shigeru Yamamoto, Shigefumi Yoshino, Kiyotaka Okuno, Hiroaki Nagano
Pages: 23-30
Published online on: 22 November 2016

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Article Open Access

Degradation of P-glycoprotein by pristimerin contributes to overcoming ABCB1-mediated chemotherapeutic drug resistance in vitro

Yan-Yan Yan, Fang Wang, Xiao-Qin Zhao, Xiao-Kun Wang, Yi-Fan Chen, Hong Liu, Yong Xie, Li-Wu Fu
Pages: 31-40
Published online on: 08 November 2016

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Article Open Access

Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential

Donatella Conconi, Valentina Chiappa, Patrizia Perego, Serena Redaelli, Giorgio Bovo, Marialuisa Lavitrano, Rodolfo Milani, Leda Dalprà, Andrea Alberto Lissoni
Pages: 41-47
Published online on: 24 November 2016

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Article Open Access

Hepatitis B virus X protein sensitizes HL-7702 cells to oxidative stress-induced apoptosis through modulation of the mitochondrial permeability transition pore

Wen-Yu Gao, Dan Li, De-En Cai, Xiao-Yun Huang, Bi-Yun Zheng, Yue-Hong Huang, Zhi-Xin Chen, Xiao-Zhong Wang
Pages: 48-56
Published online on: 07 November 2016

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Article Open Access

Yttrium-90 radioembolization for colorectal cancer liver metastases in KRAS wild-type and mutant patients: Clinical and ccfDNA studies

E. Janowski, O. Timofeeva, S. Chasovskikh, M. Goldberg, A. Kim, F. Banovac, D. Pang, A. Dritschilo, K. Unger
Pages: 57-65
Published online on: 29 November 2016

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Article Open Access

Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation

Hirotaka Hoshi, Gen Hiyama, Kosuke Ishikawa, Kiyoshi Inageda, Jiro Fujimoto, Ai Wakamatsu, Takushi Togashi, Yoshifumi Kawamura, Nobuhiko Takahashi, Arisa Higa, Naoki Goshima, Kentaro Semba, Shinya Watanabe, Motoki Takagi
Pages: 66-76
Published online on: 07 November 2016

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Article

EpCAM-independent capture of circulating tumor cells with a ‘universal CTC-chip’

Yasuhiro Chikaishi, Kazue Yoneda, Takashi Ohnaga, Fumihiro Tanaka
Pages: 77-82
Published online on: 08 November 2016

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Article

Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis

Fang Liu, Hao Zhang, Hui Song
Pages: 83-90
Published online on: 18 November 2016

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Article

Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis

Jae Hyeon Kim, Min Su Kim, Bo Hee Lee, Jin-Kyu Kim, Eun-Kyung Ahn, Hye-Jin Ko, Young-Rak Cho, Sang-Jin Lee, Gyu-Un Bae, Yong Kee Kim, Joa Sub Oh, Dong-Wan Seo
Pages: 91-97
Published online on: 15 November 2016

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Article

MET/ERK2 pathway regulates the motility of human alveolar rhabdomyosarcoma cells

Osamu Otabe, Ken Kikuchi, Kunihiko Tsuchiya, Yoshiki Katsumi, Shigeki Yagyu, Mitsuru Miyachi, Tomoko Iehara, Hajime Hosoi
Pages: 98-104
Published online on: 02 November 2016

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Article

Upregulation of CD54 and downregulation of HLA‑ABC contribute to the novel enhancement of the susceptibility of HL-60 cells to NK cell-mediated cytolysis induced by ATRA plus VPA

Huijuan Zou, Lianlian Li, Yang Han, Ruiping Ma, Qiong Liao, Jing Tian, Xiaoyu Zhang, Xia Ren, Guanhua Song, Qiang Guo, Xia Li, Huifang Ding, Guosheng Jiang
Pages: 105-114
Published online on: 02 November 2016

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Article

TGF-β1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells

Wei Wen, Ge Liu, Ke Jin, Xiang Hu
Pages: 115-122
Published online on: 09 November 2016

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Article

miR-20b reduces 5-FU resistance by suppressing the ADAM9/EGFR signaling pathway in colon cancer

Qiang Fu, Jing Cheng, Jindai Zhang, Yonglei Zhang, Xiaobing Chen, Suxia Luo, Jianguo Xie
Pages: 123-130
Published online on: 18 November 2016

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Article

Effects of the regulation of polysialyltransferase ST8SiaII on the invasiveness and metastasis of small cell lung cancer cells

Liang Gong, Xiangdong Zhou, Jingxiang Yang, Yongyuan Jiang, Heping Yang
Pages: 131-138
Published online on: 28 November 2016

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Article

Downregulation of Bmi-1 suppresses epithelial‑mesenchymal transition in melanoma

Yanting Liu, Zhaowei Chu, Qingyan Li, Bin Peng, Suyun Xu, Christine G. Lian, Songmei Geng
Pages: 139-146
Published online on: 15 November 2016

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Article

miR-148a suppresses human renal cell carcinoma malignancy by targeting AKT2 Retraction in /10.3892/or.2022.8454

Huiyan Cao, Zhiming Liu, Rong Wang, Xiaodong Zhang, Wenfa Yi, Guanyuan Nie, Yong Yu, Guolu Wang, Mingting Zhu
Pages: 147-154
Published online on: 18 November 2016

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Article

Adenovirus-mediated truncated Bid overexpression induced by the Cre/LoxP system promotes the cell apoptosis of CD133+ ovarian cancer stem cells

Qifang Long, Ru Yang, Weixian Lu, Weipei Zhu, Jundong Zhou, Cui Zheng, Dongmei Zhou, Ling Yu, Jinchang Wu
Pages: 155-162
Published online on: 21 November 2016

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Article

Silencing of argininosuccinate lyase inhibits colorectal cancer formation

Hau-Lun Huang, Wei-Ching Chen, Hui-Ping Hsu, Chien-Yu Cho, Yu‑Hsuan Hung, Chih-Yang Wang, Ming-Derg Lai
Pages: 163-170
Published online on: 07 November 2016

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Article

Bacterial ghosts as adjuvants in syngeneic tumour cell lysate-based anticancer vaccination in a murine lung carcinoma model

Jan Aleksander Kraśko, Karolina Žilionytė, Adas Darinskas, Marius Strioga, Svetlana Rjabceva, Iosif Zalutsky, Marina Derevyanko, Vladimir Kulchitsky, Werner Lubitz, Pavol Kudela, Edita Miseikyte-Kaubriene, Olha Karaman, Hennadii Didenko, Hryhorii Potebnya, Vasyl Chekhun, Vita Pašukonienė
Pages: 171-178
Published online on: 16 November 2016

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Article

Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/-9 and heparanase in MDA-MB-231 cells

Chenghua Lou, Zhihui Zhu, Yaping Zhao, Rui Zhu, Huajun Zhao
Pages: 179-184
Published online on: 23 November 2016

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Article

HMGA2 regulates epithelial-mesenchymal transition and the acquisition of tumor stem cell properties through TWIST1 in gastric cancer

Wei Li, Ziwei Wang, Lang Zha, Dequan Kong, Gang Liao, Hui Li
Pages: 185-192
Published online on: 18 November 2016

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Article

PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer

Tao Liu, Honglei Yin
Pages: 193-200
Published online on: 16 November 2016

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Article

Identification of TMPRSS2-ERG mechanisms in prostate cancer invasiveness: Involvement of MMP-9 and plexin B1

Bide Liu, Xiao Gu, Tianbao Huang, Yang Luan, Xuefei Ding
Pages: 201-208
Published online on: 28 November 2016

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Article

Protective effects of quercetin on UVB irradiation‑induced cytotoxicity through ROS clearance in keratinocyte cells

Xianbing Zhu, Ning Li, Yiling Wang, Li Ding, Houjie Chen, Yehui Yu, Xiaojun Shi
Pages: 209-218
Published online on: 04 November 2016

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Article

Synthetic paclitaxel-octreotide conjugate reverses the resistance of paclitaxel in A2780/Taxol ovarian cancer cell line

Yang Shen, Xiao-Yu Zhang, Xi Chen, Li-Li Fan, Mu-Lan Ren, Yong-Ping Wu, Kenneth Chanda, Shi-Wen Jiang
Pages: 219-226
Published online on: 18 November 2016

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Article

Potential biomarkers for the therapeutic efficacy of sorafenib, sunitinib and everolimus

Yasushi Nakai, Makito Miyake, Yosuke Morizawa, Shunta Hori, Yoshihiro Tatsumi, Satoshi Anai, Sayuri Onishi, Nobumichi Tanaka, Kiyohide Fujimoto
Pages: 227-234
Published online on: 08 November 2016

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Article

Annexin A1 is involved in resistance to 5-FU in colon cancer cells

Hisashi Onozawa, Motonobu Saito, Katsuharu Saito, Yasuyuki Kanke, Yohei Watanabe, Suguru Hayase, Wataru Sakamoto, Teruhide Ishigame, Tomoyuki Momma, Shinji Ohki, Seiichi Takenoshita
Pages: 235-240
Published online on: 08 November 2016

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Article

miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression

Senmao Li, Chenghe Wang, Xiao Yu, Huanlei Wu, Jia Hu, Shaogang Wang, Zhangqun Ye
Pages: 241-248
Published online on: 16 November 2016

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Article

Midazolam and ropivacaine act synergistically to inhibit bone cancer pain with different mechanisms in rats

Chi-Hua Guo, Lu Bai, Huang-Hui Wu, Jing Yang, Guo-Hong Cai, Si-Xiang Zeng, Xin Wang, Sheng-Xi Wu, Wei Ma
Pages: 249-258
Published online on: 10 November 2016

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Article

Immediate early response protein 2 regulates hepatocellular carcinoma cell adhesion and motility via integrin β1-mediated signaling pathway

Zhengxin Xu, Lei Zhu, Wenjuan Wu, Yuexia Liao, Weicheng Zhang, Zijing Deng, Jingyuan Shen, Qing Yuan, Lu Zheng, Yu Zhang, Weigan Shen
Pages: 259-272
Published online on: 03 November 2016

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Article

Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1

Weidong Jin, Lei Chen, Xun Cai, Yunxiao Zhang, Jianxin Zhang, Dangdang Ma, Xiong Cai, Tao Fu, Zhengping Yu, Fuxiang Yu, Gang Chen
Pages: 273-280
Published online on: 15 November 2016

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Article

Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells

Dong Hwan Kim, Min Jeong Kim, Bokyung Sung, Hongsuk Suh, Jee H. Jung, Hae Young Chung, Nam Deuk Kim
Pages: 281-288
Published online on: 07 November 2016

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Article

The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma

Yangjing Zhao, Xingwang Xie, Weijia Liao, Henghui Zhang, Hui Cao, Ran Fei, Xueyan Wang, Lai Wei, Qixiang Shao, Hongsong Chen
Pages: 289-296
Published online on: 09 November 2016

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Article

miR-592 functions as a tumor suppressor in human non-small cell lung cancer by targeting SOX9 Retraction in /10.3892/or.2021.8233

Zhihong Li, Bai Li, Liang Niu, Liang Ge
Pages: 297-304
Published online on: 25 November 2016

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Article

Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375

Lingfei Jia, Shan Zhang, Yiping Huang, Yunfei Zheng, Yehua Gan
Pages: 305-312
Published online on: 18 November 2016

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Article

Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70

Yang Zhou, Jingping Ma, Jiahong Zhang, Li He, Jianhua Gong, Cong Long
Pages: 313-322
Published online on: 29 November 2016

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Article

Loss of miR-638 promotes invasion and epithelial-mesenchymal transition by targeting SOX2 in hepatocellular carcinoma

Yu Zhang, Di Zhang, Jiong Jiang, Lei Dong
Pages: 323-332
Published online on: 23 November 2016

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Article

COL11A1 is overexpressed in gastric cancer tissues and regulates proliferation, migration and invasion of HGC-27 gastric cancer cells in vitro

Aiqing Li, Jun Li, Jinping Lin, Wei Zhuo, Jianmin Si
Pages: 333-340
Published online on: 25 November 2016

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Article

Suppression of LASP-1 attenuates the carcinogenesis of prostatic cancer cell lines: Key role of the NF-κB pathway

Wendong Sun, Liqiang Guo, Guangfeng Shao, Xiangguo Liu, Yong Guan, Ling Su, Shengtian Zhao
Pages: 341-347
Published online on: 07 November 2016

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Article

Hepatitis B virus X protein and hypoxia‑inducible factor-1α stimulate Notch gene expression in liver cancer cells

Sheng-Li Yang, Quan-Guang Ren, Tao Zhang, Xiaoli Pan, Lu Wen, Jian-Li Hu, Chao Yu, Qian-Jin He
Pages: 348-356
Published online on: 02 November 2016

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Article

Antioxidant and antitumor activities of Capparis spinosa L. and the related mechanisms

Lei Yu, Jinghui Yang, Xin Wang, Bo Jiang, Yongxue Sun, Yubin Ji
Pages: 357-367
Published online on: 16 November 2016

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Article

Antitumor effect of the combination of manumycin A and Immodin is associated with antiplatelet activity and increased granulocyte tumor infiltration in a 4T1 breast tumor model

Peter Solár, Veronika Sačková, Gabriela Hrčková, Vlasta Demečková, Monika Kassayová, Bianka Bojková, Dagmar Mudroňová, Soňa Gancarčíková, Rastislav Jendželovský, Peter Fedoročko
Pages: 368-378
Published online on: 22 November 2016

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Article

Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/β-catenin pathway

Enwen Wang, Donglin Wang, Bing Li, Huiwen Ma, Chunmei Wang, Lili Guan, Haiwei Zhang, Lin Yi, Shaolin Li
Pages: 379-387
Published online on: 15 November 2016

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Article

Silencing of ANXA3 expression by RNA interference inhibits the proliferation and invasion of breast cancer cells

Tao Zhou, Yong Li, Li Yang, Liang Liu, Yingchao Ju, Chunxiao Li
Pages: 388-398
Published online on: 16 November 2016

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Article

Inhibition of human colorectal cancer metastasis by notoginsenoside R1, an important compound from Panax notoginseng

Chang-Yin Lee, Shu-Ling Hsieh, Shuchen Hsieh, Chin-Chung Tsai, Lan-Chi Hsieh, Yu-Hao Kuo, Chih-Chung Wu
Pages: 399-407
Published online on: 07 November 2016

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Article

PLD4 promotes M1 macrophages to perform antitumor effects in colon cancer cells

Long Gao, Yan Zhou, Shu-Xian Zhou, Xian-Jing Yu, Jin-Mei Xu, Luo Zuo, Yong-Hui Luo, Xiao-An Li
Pages: 408-416
Published online on: 03 November 2016

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Article

The importance of mitochondrial folate enzymes in human colorectal cancer

Masaaki Miyo, Masamitsu Konno, Hugh Colvin, Naohiro Nishida, Jun Koseki, Koichi Kawamoto, Kenta Tsunekuni, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Pages: 417-425
Published online on: 22 November 2016

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Article

Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization

Ling Lan, Spyros Basourakos, Dai Cui, Xuemei Zuo, Wei Deng, Lili Huo, Linghai Chen, Guoying Zhang, Lili Deng, Bingyin Shi, Yong Luo
Pages: 426-434
Published online on: 07 November 2016

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Article

Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism

Zhifan Yang, Xiucheng Li, Weiqi Han, Xuanyuan Lu, Songtao Jin, Wanlei Yang, Jianlei Li, Wei He, Yu Qian
Pages: 435-441
Published online on: 07 November 2016

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Article

Triptolide inhibits tumor growth by induction of cellular senescence

Ruidong Li, Xiaofei Zhang, Xiaoying Tian, Conghuan Shen, Quanbao Zhang, Yihong Zhang, Zhengxin Wang, Feifei Wang, Yifeng Tao
Pages: 442-448
Published online on: 18 November 2016

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Article

NTN4 is associated with breast cancer metastasis via regulation of EMT-related biomarkers

Xiuping Xu, Qiuyue Yan, Yanan Wang, Xuejun Dong
Pages: 449-457
Published online on: 09 November 2016

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Article

Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53

Jiansen Li, Xiangqian Zheng, Ming Gao, Jingzhu Zhao, Yigong Li, Xiangrui Meng, Biyun Qian, Jiafeng Li
Pages: 458-464
Published online on: 29 November 2016

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Article

Oncogenic function of Plac1 on the proliferation and metastasis in hepatocellular carcinoma cells Corrigendum in /10.3892/or.2019.6955

Yuan Wu, Xiaocong Lin, Xiaoqing Di, Yonghua Chen, Hanning Zhao, Xin Wang
Pages: 465-473
Published online on: 23 November 2016

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Article

HES5 promotes cellular proliferation of non-small cell lung cancer through STAT3 signaling

Shudong Gu, Rui Zhang, Jun Gu, Xia Li, Liting Lv, Jingting Jiang, Zhen Xu, Shuo Wang, Cui Shi, Dan Ping Wang, Changping Wu
Pages: 474-482
Published online on: 22 November 2016

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Article

(-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway

Yanli Gu, Jing Wang, Lixin Peng
Pages: 483-491
Published online on: 23 November 2016

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Article

Hyperthermic carbon dioxide pneumoperitoneum reinforces the inhibition of 5-FU on the proliferation and invasion of colon cancer

Jiaying Zhao, You Lv, Yuankun Cai, Wangui Wei, Chenqing Yin, Xin Wang, Zong Hao, Chenxia Shen, Huipeng Wang
Pages: 492-500
Published online on: 08 November 2016

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MicroRNA-362 is downregulated in cervical cancer and inhibits cell proliferation, migration and invasion by directly targeting SIX1 Retraction in /10.3892/or.2024.8713

Can Shi, Zhenyu Zhang
Pages: 501-509
Published online on: 15 November 2016

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Article

PEG10 is imperative for TGF-β1-induced epithelial‑mesenchymal transition in hepatocellular carcinoma

Minfeng Zhang, Chengjun Sui, Binghua Dai, Weifeng Shen, Jiongjiong Lu, Jiamei Yang
Pages: 510-518
Published online on: 29 November 2016

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Article

Pseudolaric acid B inhibits the secretion of hepatitis B virus

Jinghua Yu, Zengyan Wang, Peiyou Ren, Ting Zhong, Yue Wang, Fengmei Song, Jingwei Hou, Xiaoyan Yu, Shucheng Hua
Pages: 519-525
Published online on: 16 November 2016

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Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis

Eungyeong Jang, So-Young Kim, Na-Rae Lee, Chae-Min Yi, Da-Rong Hong, Woo Seok Lee, Jong-Ho Kim, Kyung-Tae Lee, Bum-Joon Kim, Jang-Hoon Lee, Kyung-Soo Inn
Pages: 526-532
Published online on: 29 November 2016

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TRAIL overexpression co-regulated by Egr1 and HRE enhances radiosensitivity of hypoxic A549 cells depending on its apoptosis inducing role

Yan-Ming Yang, Fang Fang, Xin Li, Lei Yu, Zhi-Cheng Wang
Pages: 533-539
Published online on: 23 November 2016

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Histone deacetylase 8 as a novel therapeutic target in oral squamous cell carcinoma

Mee-Young Ahn, Jung-Hoon Yoon
Pages: 540-546
Published online on: 29 November 2016

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Article

Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia

Jana Šmahelová, Iva Kaštánková, Kateřina Machová Poláková, Hana Klamová, Karla Zemanová, Ruth Tachezy, Eva Hamšíková, Michal Šmahel
Pages: 547-554
Published online on: 07 November 2016

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Article

Silencing of the long non-coding RNA NEAT1 suppresses glioma stem-like properties through modulation of the miR-107/CDK6 pathway

Xiaoli Yang, Zheng Xiao, Xiaowei Du, Lina Huang, Ganqin Du
Pages: 555-562
Published online on: 22 November 2016

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miR-503 inhibits proliferation making human hepatocellular carcinoma cells susceptible to 5‑fluorouracil by targeting EIF4E

Xiaoyan Yang, Jinglei Zang, Xia Pan, Jie Yin, Qiong Xiang, Jia Yu, Runliang Gan, Xiaoyong Lei
Pages: 563-570
Published online on: 07 November 2016

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miR-20a-directed regulation of BID is associated with the TRAIL sensitivity in colorectal cancer

Guanli Huang, Xiangjian Chen, Yefeng Cai, Xiaobo Wang, Chungen Xing
Pages: 571-578
Published online on: 28 November 2016

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Article

BMI-1 interacts with sMEK1 and inactivates sMEK1-induced apoptotic cell death

Boh-Ram Kim, Youngjoo Kwon, Seung Bae Rho
Pages: 579-586
Published online on: 21 November 2016

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Propofol inhibits the growth and survival of gastric cancer cells in vitro through the upregulation of ING3

Cheng Yang, Jie Gao, Nuo Yan, Banglin Wu, Yiqing Ren, Hui Li, Jiamin Liang
Pages: 587-593
Published online on: 04 November 2016

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Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells

Dan Jiang, Lingyao Wang, Tong Zhao, Zhaoyu Zhang, Renxia Zhang, Jingji Jin, Yong Cai, Fei Wang
Pages: 594-600
Published online on: 15 November 2016

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Expression of angiogenic growth factors VEGF, bFGF and ANG1 in colon cancer after bevacizumab treatment in vitro: A potential self-regulating mechanism

Minjian Zhao, Zhaoshi Yu, Zhihong Li, Jun Tang, Xu Lai, Liming Liu
Pages: 601-607
Published online on: 08 November 2016

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miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer

Dong Wang, Junjie Ma, Xiangyu Ji, Feng Xu, Yucheng Wei
Pages: 608-616
Published online on: 02 November 2016

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Article

Induction of DNA damage and apoptosis in human leukemia cells by efavirenz

Ansgar Brüning, Julia Jückstock, Bernd Kost, Panagiotis Tsikouras, Tobias Weissenbacher, Sven Mahner, Ioannis Mylonas
Pages: 617-621
Published online on: 15 November 2016

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Article

Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma

Xinhua Zhu, Yu Ouyang, Fei Zhong, Qiru Wang, Linlin Ding, Peipei Zhang, Lingling Chen, Hong Liu, Song He
Pages: 622-630
Published online on: 08 November 2016

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Article

MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells

Na Liu, Jie Li, Zhenghao Zhao, Jia Han, Ting Jiang, Yanke Chen, Ni Hou, Chen Huang
Pages: 631-639
Published online on: 08 November 2016

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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