Testin is a tumor suppressor in non-small cell lung cancer

  • Authors:
    • Ming Wang
    • Qian Wang
    • Wen-Jia Peng
    • Jun-Feng Hu
    • Zu-Yi Wang
    • Hao Liu
    • Li-Nian Huang
  • View Affiliations

  • Published online on: December 14, 2016     https://doi.org/10.3892/or.2016.5316
  • Pages: 1027-1035
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Abstract

The Testin gene was previously identified in the fragile chromosomal region FRA7G at 7q31.2. It has been implicated in several types of cancers including prostate, ovarian, breast and gastric cancer. In the present study, we investigated the function of the candidate tumor-suppressor Testin gene in non-small cell lung cancer (NSCLC). In NSCLC cell lines, we observed lower expression of Testin compared to that noted in normal human bronchial epithelial cells. MTT assays, flow cytometry, clonogenic assay and invasion assay showed that the overexpression of the Testin gene inhibited cancer cell proliferation, invasion and colony formation. In tumor xenograft models, Testin markedly inhibited lung cancer cell xenograft formation and growth in athymic nude mice. Taken together, these data suggest that Testin plays an important role in the development and progression of NSCLC. Testin may be an effective novel target in NSCLC prevention and treatment.
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February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wang M, Wang Q, Peng W, Hu J, Wang Z, Liu H and Huang L: Testin is a tumor suppressor in non-small cell lung cancer. Oncol Rep 37: 1027-1035, 2017.
APA
Wang, M., Wang, Q., Peng, W., Hu, J., Wang, Z., Liu, H., & Huang, L. (2017). Testin is a tumor suppressor in non-small cell lung cancer. Oncology Reports, 37, 1027-1035. https://doi.org/10.3892/or.2016.5316
MLA
Wang, M., Wang, Q., Peng, W., Hu, J., Wang, Z., Liu, H., Huang, L."Testin is a tumor suppressor in non-small cell lung cancer". Oncology Reports 37.2 (2017): 1027-1035.
Chicago
Wang, M., Wang, Q., Peng, W., Hu, J., Wang, Z., Liu, H., Huang, L."Testin is a tumor suppressor in non-small cell lung cancer". Oncology Reports 37, no. 2 (2017): 1027-1035. https://doi.org/10.3892/or.2016.5316