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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
February-2017 Volume 37 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

The Met tyrosine kinase receptor as a therapeutic target and a potential cancer stem cell factor responsible for therapy resistance (Review)

Katarzyna Miekus
Pages: 647-656
Published online on: 07 December 2016

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Review

Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review)

Gang Wang, Jun-Jie Wang, Xing-Li Fu, Rui Guang, Shing-Shun Tony To
Pages: 657-670
Published online on: 09 December 2016

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Review

Immature myeloid-derived suppressor cells: A bridge between inflammation and cancer (Review)

Caterina Musolino, Alessandro Allegra, Govanni Pioggia, Sebastiano Gangemi
Pages: 671-683
Published online on: 05 December 2016

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Article Open Access

Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-γ

Hiromi Okuyama, Akira Tominaga, Satoshi Fukuoka, Takahiro Taguchi, Yutaka Kusumoto, Shiro Ono
Pages: 684-694
Published online on: 02 January 2017

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Article Open Access

Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses

Hisanori Shoji, Masahiko Motegi, Yosuke Takakusagi, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi, Kyoji Ogoshi
Pages: 695-704
Published online on: 07 December 2016

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Article Open Access

Fulvestrant reverses doxorubicin resistance in multidrug-resistant breast cell lines independent of estrogen receptor expression

Yuan Huang, Donghai Jiang, Meihua Sui, Xiaojia Wang, Weimin Fan
Pages: 705-712
Published online on: 14 December 2016

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Article Open Access

Transforming growth factor-β1 suppresses bone morphogenetic protein-2-induced mesenchymal-epithelial transition in HSC-4 human oral squamous cell carcinoma cells via Smad1/5/9 pathway suppression

Takahiro Chiba, Akira Ishisaki, Seiko Kyakumoto, Toshiyuki Shibata, Hiroyuki Yamada, Masaharu Kamo
Pages: 713-720
Published online on: 28 December 2016

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Article Open Access

Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis

Jun-Feng Chen, Bi-Xia Yu, Rui Yu, Liang Ma, Xiu-Yi Lv, Yue Cheng, Qi Ma
Pages: 721-728
Published online on: 05 January 2017

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Article Open Access

Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis

Hao Jin, Xin Jin, Boran Cao, Wenbo Wang
Pages: 729-736
Published online on: 16 December 2016

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Article Open Access

NF‑κB inhibition is associated with OPN/MMP‑9 downregulation in cutaneous melanoma

Claudio Guarneri, Valentina Bevelacqua, Jerry Polesel, Luca Falzone, Patrizia S. Cannavò, Demetrios A. Spandidos, Grazia Malaponte, Massimo Libra
Pages: 737-746
Published online on: 10 January 2017

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Article Open Access

Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-β1/Smad signaling pathway

Xiaoyu Wang, Chun Liu, Jiaqi Wang, Yue Fan, Zhenghua Wang, Yuanyuan Wang
Pages: 747-753
Published online on: 07 December 2016

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Article Open Access

Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation

Zhizhen Liu, Lianming Liao, Zhiyun Cao, Xuzheng Chen, Jian Du
Pages: 754-760
Published online on: 28 December 2016

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Article Open Access

ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage response

Hongchang Shen, Liguang Wang, Jiangang Zhang, Wei Dong, Tiehong Zhang, Yang Ni, Hongxin Cao, Kai Wang, Yun Li, Yibing Wang, Jiajun Du
Pages: 761-767
Published online on: 28 December 2016

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Article Open Access

Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma

Xiaobo Cui, Laixiao Song, Yunfei Bai, Yaping Wang, Boqian Wang, Wei Wang
Pages: 768-776
Published online on: 29 December 2016

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Article

Delphinidin inhibits angiogenesis through the suppression of HIF-1α and VEGF expression in A549 lung cancer cells

Mun-Hyeon Kim, Yun-Jeong Jeong, Hyun-Ji Cho, Hyang-Sook Hoe, Kwan-Kyu Park, Yoon-Yub Park, Yung Hyun Choi, Cheorl-Ho Kim, Hyeun-Wook Chang, Young-Ja Park, Il-Kyung Chung, Young-Chae Chang
Pages: 777-784
Published online on: 07 December 2016

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Article

High concordance rate of KRAS/BRAF mutations and MSI-H between primary colorectal cancer and corresponding metastases

Kenji Fujiyoshi, Gou Yamamoto, Akemi Takahashi, Yoshiko Arai, Mina Yamada, Miho Kakuta, Kensei Yamaguchi, Yoshito Akagi, Yoji Nishimura, Hirohiko Sakamoto, Kiwamu Akagi
Pages: 785-792
Published online on: 15 December 2016

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Article

2-Methoxyestradiol inhibits the proliferation and migration and reduces the radioresistance of nasopharyngeal carcinoma CNE-2 stem cells via NF-κB/HIF-1 signaling pathway inactivation and EMT reversal

Shun-Long Wu, Ya-Jun Li, Kui Liao, Lei Shi, Na Zhang, Shuang Liu, Yao-Yao Hu, Shao-Lin Li, Ying Wang
Pages: 793-802
Published online on: 14 December 2016

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Article

MicroRNA-194 suppresses prostate cancer migration and invasion by downregulating human nuclear distribution protein

Qi Kong, Xu-Shen Chen, Tian Tian, Xiang-You Xia, Peilin Xu
Pages: 803-812
Published online on: 08 December 2016

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Article

ELK3 promotes the migration and invasion of liver cancer stem cells by targeting HIF-1α

Joon Ho Lee, Wonhee Hur, Sung Woo Hong, Jung-Hee Kim, Sung Min Kim, Eun Byul Lee, Seung Kew Yoon
Pages: 813-822
Published online on: 07 December 2016

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Article

miR-134 suppresses the migration and invasion of non‑small cell lung cancer by targeting ITGB1

Qin Qin, Furong Wei, Jianbo Zhang, Baosheng Li
Pages: 823-830
Published online on: 03 January 2017

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Article

High-mobility group box 1 is overexpressed in cervical carcinoma and promotes cell invasion and migration in vitro

Xiaoao Pang, Yao Zhang, Shulan Zhang
Pages: 831-840
Published online on: 14 December 2016

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Article

Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231

Chao Meng, Linlin Song, Juan Wang, Di Li, Yanhong Liu, Xiaoguang Cui
Pages: 841-848
Published online on: 23 December 2016

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Article

Bcl-2 overexpression contributes to laryngeal carcinoma cell survival by forming a complex with Hsp90β

Sai Li, Jincheng Li, Tian Hu, Chuhong Zhang, Xiu Lv, Sha He, Hanxing Yan, Yixi Tan, Meiling Wen, Mingsheng Lei, Jianhong Zuo
Pages: 849-856
Published online on: 07 December 2016

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Article

DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma

Jie Sun, Fangfang Bi, Yang Yang, Yuan Zhang, Aihua Jin, Jinzi Li, Zhenhua Lin
Pages: 857-864
Published online on: 08 December 2016

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Article

Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway

Huanhuan Chen, Yuechun Huang, Junbin Huang, Lizhen Lin, Gang Wei
Pages: 865-870
Published online on: 07 December 2016

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Article

Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells

Lifu Luo, Jizhe Cui, Zhitong Feng, Yana Li, Mengdi Wang, Yong Cai, Yazhen Wu, Jingji Jin
Pages: 871-878
Published online on: 16 December 2016

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Article

DNALK2 inhibits the proliferation and invasiveness of breast cancer MDA-MB-231 cells through the Smad-dependent pathway

Ke Wang, Xiaoxiao Sun, Hong Lei Feng, Chang Fei, Yan Zhang
Pages: 879-886
Published online on: 30 December 2016

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Article

Promoter methylation attenuates SHP1 expression and function in patients with primary central nervous system lymphoma

Jing Liu, Yaming Wang, Xuefei Sun, Nan Ji, Shengjun Sun, Yajie Wang, Fusheng Liu, Qu Cui, Chen Wang, Yuanbo Liu
Pages: 887-894
Published online on: 08 December 2016

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Article

Luteolin suppresses the metastasis of triple-negative breast cancer by reversing epithelial-to-mesenchymal transition via downregulation of β-catenin expression

Dan Lin, Ge Kuang, Jingyuan Wan, Xiang Zhang, Hongzhong Li, Xia Gong, Hongyuan Li
Pages: 895-902
Published online on: 12 December 2016

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Article

High expression of RAB43 predicts poor prognosis and is associated with epithelial-mesenchymal transition in gliomas

Ming-Zhi Han, Bin Huang, An-Jing Chen, Xin Zhang, Ran Xu, Jian Wang, Xin-Gang Li
Pages: 903-912
Published online on: 03 January 2017

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Article

MicroRNA-138-5p controls sensitivity of nasopharyngeal carcinoma to radiation by targeting EIF4EBP1

Wei Gao, Jacky Wei Kei Lam, John Zeng-Hong Li, Si-Qi Chen, Raymond King-Yin Tsang, Jimmy Yu-Wai Chan, Thian-Sze Wong
Pages: 913-920
Published online on: 04 January 2017

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Article

CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner

Songping Xie, Zhenbo Tu, Jie Xiong, Ganjun Kang, Lina Zhao, Weidong Hu, Haiyan Tan, Kingsley Miyanda Tembo, Qianshan Ding, Xinzhou Deng, Jie Huang, Qiuping Zhang
Pages: 921-928
Published online on: 02 December 2016

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Article

Expression of glia maturation factor γ is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro

Huili Wang, Zhijiang Chen, Hongen Chang, Xiaoping Mu, Wenyu Deng, Zhaohu Yuan, Fang Yao, Yan Liu, Rongjia Mai, Bingyi Wu
Pages: 929-936
Published online on: 09 January 2017

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Article

Lung cancer gene therapy: Transferrin and hyaluronic acid dual ligand-decorated novel lipid carriers for targeted gene delivery

Bin Zhang, Yueying Zhang, Dongmei Yu
Pages: 937-944
Published online on: 07 December 2016

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Article

miRNA-301a induces apoptosis of chronic myelogenous leukemia cells by directly targeting TIMP2/ERK1/2 and AKT pathways

Xianbao Huang, Ling Qi, Wei Lu, Gangping Yang, Yan Chen, Rongyan Zhang, Jia Rao, Dexiang Ji, Ruibin Huang, Guoan Chen
Pages: 945-952
Published online on: 22 December 2016

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Article

Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells

Yan He, Huarong Huang, Chelsea Farischon, Dongli Li, Zhiyun Du, Kun Zhang, Xi Zheng, Susan Goodin
Pages: 953-960
Published online on: 04 January 2017

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Article

hsa-miR-631 resensitizes bortezomib-resistant multiple myeloma cell lines by inhibiting UbcH10

Hao Xi, Lu Li, Juan Du, Ran An, Rong Fan, Jing Lu, Yin-Xiang Wu, Shu-Xie Wu, Jian Hou, Li-Ming Zhao
Pages: 961-968
Published online on: 14 December 2016

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Article

Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells

Yu-Hsuan Hung, Hau-Lun Huang, Wei-Ching Chen, Meng-Chi Yen, Chien-Yu Cho, Tzu-Yang Weng, Chih-Yang Wang, Yi-Ling Chen, Li-Tzong Chen, Ming-Derg Lai
Pages: 969-978
Published online on: 23 December 2016

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Article

Expression pattern of DKK3, dickkopf WNT signaling pathway inhibitor 3, in the malignant progression of oral submucous fibrosis

Shanghui Zhou, Yun Zhu, Mubarak Mashrah, Xinyu Zhang, Zhijing He, Zhigang Yao, Chunye Zhang, Feng Guo, Yongjie Hu, Chenping Zhang
Pages: 979-985
Published online on: 08 December 2016

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Article

Expression of the promyelocytic leukemia protein without the nuclear localization signal as a novel diagnostic marker for acute promyelocytic leukemia

Ting Xu, Xiao-Qun Yang, Kai-Ling Jiang, Hui Wang, Peng-Peng Ma, Liang Zhong, Bei-Zhong Liu
Pages: 986-994
Published online on: 09 January 2017

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Article

Formulation of temozolomide-loaded nanoparticles and their targeting potential to melanoma cells

Guan Jiang, Ronghua Li, Jianqin Tang, Yafeng Ma, Xiaoyang Hou, Chunsheng Yang, Wenwen Guo, Yong Xin, Yanqun Liu
Pages: 995-1001
Published online on: 29 December 2016

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Article

Escin induces apoptosis in human renal cancer cells through G2/M arrest and reactive oxygen species-modulated mitochondrial pathways

Sheau-Yun Yuan, Chen-Li Cheng, Shian-Shiang Wang, Hao-Chung Ho, Kun-Yuan Chiu, Chuan-Shu Chen, Cheng-Che Chen, Ming-Yuh Shiau, Yen-Chuan Ou
Pages: 1002-1010
Published online on: 03 January 2017

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Article

Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways

Zhenhua Yang, Ying Liu, Changzheng Shi, Yuqin Zhang, Rongzhao Lv, Rong Zhang, Qian Wang, Yiming Wang
Pages: 1011-1019
Published online on: 09 January 2017

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Article

A novel, rapid point-of-care test for lung cancer patients to detect epidermal growth factor receptor gene mutations by using real-time droplet-PCR and fresh liquid cytology specimens

Shiho Asaka, Akihiko Yoshizawa, Kazuyuki Matsuda, Akemi Yamaguchi, Hiroshi Yamamoto, Takayuki Shiina, Rie Nakata, Kaoru Ogawa, Meng Zhang, Takayuki Honda
Pages: 1020-1026
Published online on: 02 December 2016

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Article

Testin is a tumor suppressor in non-small cell lung cancer

Ming Wang, Qian Wang, Wen-Jia Peng, Jun-Feng Hu, Zu-Yi Wang, Hao Liu, Li-Nian Huang
Pages: 1027-1035
Published online on: 14 December 2016

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Article

Regorafenib induces extrinsic and intrinsic apoptosis through inhibition of ERK/NF-κB activation in hepatocellular carcinoma cells

Jai-Jen Tsai, Po-Jung Pan, Fei-Ting Hsu
Pages: 1036-1044
Published online on: 20 December 2016

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Article

Overexpression of SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7

Huaqi Yin, Zhengzuo Sheng, Xiaowei Zhang, Yiqing Du, Caipeng Qin, Huixin Liu, Yaojun Dun, Qi Wang, Chengyue Jin, Yanhui Zhao, Tao Xu
Pages: 1045-1051
Published online on: 02 December 2016

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Article

miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7

Jing Xu, Weibing Wu, Jun Wang, Chenjun Huang, Wei Wen, Fei Zhao, Xinfeng Xu, Xianglong Pan, Wei Wang, Quan Zhu, Liang Chen
Pages: 1052-1058
Published online on: 14 December 2016

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Article

Elevated expression of TrpC5 and GLUT1 is associated with chemoresistance in colorectal cancer

Teng Wang, Kuan Ning, Ting-Xun Lu, Dong Hua
Pages: 1059-1065
Published online on: 15 December 2016

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Article

Identifying the optimal gene and gene set in hepatocellular carcinoma based on differential expression and differential co-expression algorithm

Li-Yang Dong, Wei-Zhong Zhou, Jun-Wei Ni, Wei Xiang, Wen-Hao Hu, Chang Yu, Hai-Yan Li
Pages: 1066-1074
Published online on: 23 December 2016

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Article

miR-196b/miR-1290 participate in the antitumor effect of resveratrol via regulation of IGFBP3 expression in acute lymphoblastic leukemia

Wei Zhou, Shunqing Wang, Yi Ying, Ruiqing Zhou, Ping Mao
Pages: 1075-1083
Published online on: 15 December 2016

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Article

Ellagic acid inhibits human glioblastoma growth in vitro and in vivo

Dongliang Wang, Qianxue Chen, Yinqiu Tan, Baohui Liu, Chao Liu
Pages: 1084-1092
Published online on: 22 December 2016

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Article

miR-375 inhibits cancer stem cell phenotype and tamoxifen resistance by degrading HOXB3 in human ER-positive breast cancer

Hui Fu, Lei Fu, Chao Xie, Wen-Shu Zuo, Yan-Song Liu, Mei-Zhu Zheng, Jin-Ming Yu
Pages: 1093-1099
Published online on: 09 January 2017

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Article

Death-associated protein kinase 3 controls the tumor progression of A549 cells through ERK MAPK/c-Myc signaling

Satoru Kake, Tatsuya Usui, Takashi Ohama, Hideyuki Yamawaki, Koichi Sato
Pages: 1100-1106
Published online on: 09 January 2017

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Article

HELQ reverses the malignant phenotype of osteosarcoma cells via CHK1-RAD51 signaling pathway

Dong Ning Liu, Yun Fei Zhou, Ai Fen Peng, Xin Hua Long, Xuan Yin Chen, Zhi Li Liu, Hong Xia
Pages: 1107-1113
Published online on: 20 December 2016

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Article

CXCL7 promotes proliferation and invasion of cholangiocarcinoma cells

Qian Guo, Zhixiang Jian, Baoqing Jia, Liang Chang
Pages: 1114-1122
Published online on: 12 December 2016

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Article

miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD

Guoqiang Yu, Zhaohui Jia, Zhongling Dou
Pages: 1123-1131
Published online on: 16 December 2016

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Article

Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

Bo Wang, Xin-Huai Zhao
Pages: 1132-1140
Published online on: 08 December 2016

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Article

Inhibition of casein kinase 2 prevents growth of human osteosarcoma

Kengo Takahashi, Takao Setoguchi, Arisa Tsuru, Yoshinobu Saitoh, Satoshi Nagano, Yasuhiro Ishidou, Shingo Maeda, Tatsuhiko Furukawa, Setsuro Komiya
Pages: 1141-1147
Published online on: 09 December 2016

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Article

miR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion

Shun-Jie Chen, Ping Wu, Li-Jing Sun, Bo Zhou, Wei Niu, Shuang Liu, Fu-Jun Lin, Geng-Ru Jiang
Pages: 1148-1158
Published online on: 07 December 2016

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MicroRNA-302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma Retraction in /10.3892/or.2025.9011

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Pages: 1159-1167
Published online on: 15 December 2016

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Article

Thioridazine elicits potent antitumor effects in colorectal cancer stem cells

Chen Zhang, Ping Gong, Pengfei Liu, Ning Zhou, Yulai Zhou, Yi Wang
Pages: 1168-1174
Published online on: 14 December 2016

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Article

Combined analysis of gene expression, miRNA expression and DNA methylation profiles of osteosarcoma

Wenpeng Zhang, Shiliang Han, Kang Sun
Pages: 1175-1181
Published online on: 15 December 2016

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Article

Silencing of GP73 inhibits invasion and metastasis via suppression of epithelial-mesenchymal transition in hepatocellular carcinoma Retraction in /10.3892/or.2025.8943

Ying Yang, Qiang Liu, Hua Zhang, Huarong Zhao, Ruin Mao, Zhipeng Li, Sha Ya, Chunli Jia, Yongxing Bao
Pages: 1182-1188
Published online on: 04 January 2017

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Article

Downregulation of the N-myc downstream regulated gene 1 is related to enhanced proliferation, invasion and migration of pancreatic cancer

Gang Cen, Kundong Zhang, Jun Cao, Zhengjun Qiu
Pages: 1189-1195
Published online on: 05 January 2017

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Article

Silencing of Forkhead box D1 inhibits proliferation and migration in glioma cells

Yuan-Feng Gao, Tao Zhu, Xiao-Yuan Mao, Chen-Xue Mao, Ling Li, Ji-Ye Yin, Hong-Hao Zhou, Zhao-Qian Liu
Pages: 1196-1202
Published online on: 02 January 2017

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Article

Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway

Feng Gao, Gang Deng, Wenbin Liu, Kechao Zhou, Ming Li
Pages: 1203-1211
Published online on: 03 January 2017

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Article

17β-estradiol-induced growth of triple-negative breast cancer cells is prevented by the reduction of GPER expression after treatment with gefitinib

Rainer Girgert, Günter Emons, Carsten Gründker
Pages: 1212-1218
Published online on: 08 December 2016

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Article

Anticancer effect of luteolin is mediated by downregulation of TAM receptor tyrosine kinases, but not interleukin-8, in non-small cell lung cancer cells

Youn Ju Lee, Taeho Lim, Min Su Han, Sun-Hwa Lee, Suk‑Hwan Baek, Hong-Yan Nan, Chuhee Lee
Pages: 1219-1226
Published online on: 23 December 2016

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Article

MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma Retraction in /10.3892/or.2025.8965

Jiejing Zhou, Yanjun Zhang, Yuhong Qi, Dequan Yu, Qiuju Shao, Jun Liang
Pages: 1227-1234
Published online on: 05 December 2016

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Article

Fibroblast growth factor 18 promotes proliferation and migration of H460 cells via the ERK and p38 signaling pathways

Taotao Chen, Weiyue Gong, Haishan Tian, Haijun Wang, Shenghui Chu, Jisheng Ma, Huanhuan Yang, Jiliang Cheng, Min Liu, Xiaokun Li, Chao Jiang
Pages: 1235-1242
Published online on: 07 December 2016

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Article

Isomahanine induces endoplasmic reticulum stress and simultaneously triggers p38 MAPK-mediated apoptosis and autophagy in multidrug-resistant human oral squamous cell carcinoma cells

Tanyarath Utaipan, Anan Athipornchai, Apichart Suksamrarn, Surasak Chunsrivirot, Warangkana Chunglok
Pages: 1243-1252
Published online on: 04 January 2017

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Article

Co-delivery of doxorubicin and pH-sensitive curcumin prodrug by transferrin-targeted nanoparticles for breast cancer treatment

Tongxing Cui, Sihao Zhang, Hong Sun
Pages: 1253-1260
Published online on: 02 January 2017

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Article

MicroRNA-1271 inhibits proliferation and promotes apoptosis of multiple myeloma cells through inhibiting smoothened-mediated Hedgehog signaling pathway

Zhengwei Xu, Chen Huang, Dingjun Hao
Pages: 1261-1269
Published online on: 08 December 2016

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Article

ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation

Ueihuei Peng, Zhihao Wang, Sa Pei, Yunchao Ou, Pengchao Hu, Wanhong Liu, Jiquan Song
Pages: 1270-1276
Published online on: 28 December 2016

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Article

Gallic acid induces HeLa cell death via increasing GSH depletion rather than ROS levels

Woo Hyun Park
Pages: 1277-1283
Published online on: 23 December 2016

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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