NHE1 is upregulated in gastric cancer and regulates gastric cancer cell proliferation, migration and invasion

Corrigendum in: /10.3892/or.2019.7055

  • Authors:
    • Rui Xie
    • Haibo Wang
    • Hai Jin
    • Guorong Wen
    • Biguang Tuo
    • Jingyu Xu
  • View Affiliations

  • Published online on: January 18, 2017     https://doi.org/10.3892/or.2017.5386
  • Pages: 1451-1460
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Na+/H+ exchanger isoform 1 (NHE1) is known to play a key role in regulating intracellular pH and osmotic homeostasis and is involved in the development and progression of several types of cancer. However, the function and specific mechanism of NHE1 in gastric cancer (GC) are not clearly understood. In the present study, we report that NHE1 is overexpressed in tissues and cell lines from GC patients, and knockdown or inhibition of NHE1 suppressed GC cell proliferation via regulation of G1/S and G2/M cell cycle phase transitions, concomitant with a marked decrease in positive cell cycle regulators, including cyclin D1 and cyclin B1. Likewise, NHE1 was required for GC cell migration and invasion through the regulation of epithelial-mesenchymal transition (EMT) proteins, and NHE1 inhibition resulted in an acidic intracellular environment, providing possible mechanisms underlying NHE1-mediated GC progression both in vitro and in vivo. These data highlight the important role of NHE1 in GC progression and suggest that NHE1 may be a useful target for GC therapy.
View Figures
View References

Related Articles

Journal Cover

March-2017
Volume 37 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xie R, Wang H, Jin H, Wen G, Tuo B and Xu J: NHE1 is upregulated in gastric cancer and regulates gastric cancer cell proliferation, migration and invasion Corrigendum in /10.3892/or.2019.7055. Oncol Rep 37: 1451-1460, 2017
APA
Xie, R., Wang, H., Jin, H., Wen, G., Tuo, B., & Xu, J. (2017). NHE1 is upregulated in gastric cancer and regulates gastric cancer cell proliferation, migration and invasion Corrigendum in /10.3892/or.2019.7055. Oncology Reports, 37, 1451-1460. https://doi.org/10.3892/or.2017.5386
MLA
Xie, R., Wang, H., Jin, H., Wen, G., Tuo, B., Xu, J."NHE1 is upregulated in gastric cancer and regulates gastric cancer cell proliferation, migration and invasion Corrigendum in /10.3892/or.2019.7055". Oncology Reports 37.3 (2017): 1451-1460.
Chicago
Xie, R., Wang, H., Jin, H., Wen, G., Tuo, B., Xu, J."NHE1 is upregulated in gastric cancer and regulates gastric cancer cell proliferation, migration and invasion Corrigendum in /10.3892/or.2019.7055". Oncology Reports 37, no. 3 (2017): 1451-1460. https://doi.org/10.3892/or.2017.5386