AXL and MET receptor tyrosine kinases are essential for lung cancer metastasis

Corrigendum in: /10.3892/or.2017.5482

  • Authors:
    • Yun Jung Choi
    • Ji Hye Kim
    • Jin Kyung Rho
    • Joong Sun Kim
    • Chang-Min Choi
    • Woo Sung Kim
    • Jaekyoung Son
    • Jae Cheol Lee
  • View Affiliations

  • Published online on: March 1, 2017     https://doi.org/10.3892/or.2017.5482
  • Pages: 2201-2208
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Abstract

The AXL and MET receptors regulate key processes in tumor growth, metastasis, and drug resistance; thus, they have recently been implicated as promising therapeutic targets in various tumors. We investigated the metastatic potential and crosstalk between these receptors in non‑small cell lung cancer (NSCLC). We found that the treatment of NSCLC cells with hepatocyte growth factor (HGF) and growth arrest-specific 6 (Gas6), as ligands for MET and AXL, respectively, promoted their migration and invasion ability. However, treatment with inhibitors of each of these receptors significantly reduced the migratory and invasiveness of the cells, although their inhibitory rates varied according to the inhibition of each receptor. In addition, the suppression of each receptor by shRNA resulted in reduced migration and invasiveness. Notably, the suppression of AXL was more effective than the suppression of MET in the inhibition of migration and invasion. In accordance with in vitro results, when the cells were transferred via tail vein injection, AXL inhibition was more efficient in attenuating metastasis than MET inhibition. Clinically, AXL or MET expression is associated with a poor prognosis in primary tumors of NSCLC. In summary, AXL and MET can regulate tumor metastasis, but AXL was shown to be more potent than MET in lung metastasis. Thus, we conclude that AXL might be a suitable therapeutic target for the inhibition of lung metastasis.
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April-2017
Volume 37 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Choi YJ, Kim JH, Rho JK, Kim JS, Choi C, Kim WS, Son J and Lee JC: AXL and MET receptor tyrosine kinases are essential for lung cancer metastasis Corrigendum in /10.3892/or.2017.5482. Oncol Rep 37: 2201-2208, 2017
APA
Choi, Y.J., Kim, J.H., Rho, J.K., Kim, J.S., Choi, C., Kim, W.S. ... Lee, J.C. (2017). AXL and MET receptor tyrosine kinases are essential for lung cancer metastasis Corrigendum in /10.3892/or.2017.5482. Oncology Reports, 37, 2201-2208. https://doi.org/10.3892/or.2017.5482
MLA
Choi, Y. J., Kim, J. H., Rho, J. K., Kim, J. S., Choi, C., Kim, W. S., Son, J., Lee, J. C."AXL and MET receptor tyrosine kinases are essential for lung cancer metastasis Corrigendum in /10.3892/or.2017.5482". Oncology Reports 37.4 (2017): 2201-2208.
Chicago
Choi, Y. J., Kim, J. H., Rho, J. K., Kim, J. S., Choi, C., Kim, W. S., Son, J., Lee, J. C."AXL and MET receptor tyrosine kinases are essential for lung cancer metastasis Corrigendum in /10.3892/or.2017.5482". Oncology Reports 37, no. 4 (2017): 2201-2208. https://doi.org/10.3892/or.2017.5482