Preclinical evaluation of cisplatin-incorporated bio-nanocapsules as chemo-radiotherapy for human hepatocellular carcinoma

  • Authors:
    • Seol Hwa Shin
    • Seok Soon Park
    • Kyoung Jin Lee
    • Eun Jin Ju
    • Jin Park
    • Eun Jeong Ko
    • Joohee Jung
    • Shun'ich Kuroda
    • Seung-Mo Hong
    • Jung Jin Hwang
    • Jung Shin Lee
    • Si Yeol Song
    • Seong-Yun Jeong
    • Eun Kyung Choi
  • View Affiliations

  • Published online on: August 21, 2017     https://doi.org/10.3892/or.2017.5910
  • Pages: 2259-2266
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Abstract

The incidence of hepatocellular carcinoma (HCC) has continued to increase worldwide, and advanced HCC is difficult to treat using the currently available therapeutics. Chemoradiotherapy with cisplatin (cis-diamminedichloroplatinum, CDDP) is expected to confer a curative benefit on HCC patients; however, its application is limited due to side-effects such as acute nephrotoxicity as well as the conventionally limited application of chemoradiotherapy for HCC. For the practical application of this drug in the clinical setting, we formulated a novel drug carrier-comprising bio-nanocapsule (BNC) and liposomal CDDP (BNC-LP-CDDP) that recognizes the human liver and releases CDDP. BNC-LP-CDDP showed selectively high cytotoxicity for HCC cells, and markedly reduced the survival fractions of HCC when combined with ionizing radiation (IR) treatment in in vitro assays. In particular, the treatment of mice bearing human HCC with BNC-LP-CDDP and 3 Gy IR showed 95.68% growth inhibition, whereas IR treatment alone showed 65.6% growth inhibition. Moreover, BNC-LP-CDDP led to the withdrawal of CDDP-induced nephrotoxicity. These results indicate that BNC-LP-CDDP in combination with IR markedly enhanced the chemo-radiotherapeutic efficacy and eliminated CDDP induced nephrotoxicity, thus, suggesting the potential for its clinical application as human HCC therapy.
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October-2017
Volume 38 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Shin SH, Park SS, Lee KJ, Ju EJ, Park J, Ko EJ, Jung J, Kuroda S, Hong S, Hwang JJ, Hwang JJ, et al: Preclinical evaluation of cisplatin-incorporated bio-nanocapsules as chemo-radiotherapy for human hepatocellular carcinoma. Oncol Rep 38: 2259-2266, 2017
APA
Shin, S.H., Park, S.S., Lee, K.J., Ju, E.J., Park, J., Ko, E.J. ... Choi, E. (2017). Preclinical evaluation of cisplatin-incorporated bio-nanocapsules as chemo-radiotherapy for human hepatocellular carcinoma. Oncology Reports, 38, 2259-2266. https://doi.org/10.3892/or.2017.5910
MLA
Shin, S. H., Park, S. S., Lee, K. J., Ju, E. J., Park, J., Ko, E. J., Jung, J., Kuroda, S., Hong, S., Hwang, J. J., Lee, J. S., Song, S. Y., Jeong, S., Choi, E."Preclinical evaluation of cisplatin-incorporated bio-nanocapsules as chemo-radiotherapy for human hepatocellular carcinoma". Oncology Reports 38.4 (2017): 2259-2266.
Chicago
Shin, S. H., Park, S. S., Lee, K. J., Ju, E. J., Park, J., Ko, E. J., Jung, J., Kuroda, S., Hong, S., Hwang, J. J., Lee, J. S., Song, S. Y., Jeong, S., Choi, E."Preclinical evaluation of cisplatin-incorporated bio-nanocapsules as chemo-radiotherapy for human hepatocellular carcinoma". Oncology Reports 38, no. 4 (2017): 2259-2266. https://doi.org/10.3892/or.2017.5910