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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October-2017 Volume 38 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Age at menopause and hormone replacement therapy as risk factors for head and neck and oesophageal cancer (Review)

Caroline E. McCarthy, John K. Field, Michael W. Marcus
Pages: 1915-1922
Published online on: 01 August 2017

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Review

Long non-coding RNAs on the stage of cervical cancer (Review)

Junxue Dong, Manman Su, Weiqin Chang, Kun Zhang, Shuying Wu, Tianmin Xu
Pages: 1923-1931
Published online on: 14 August 2017

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Article Open Access

Acid ceramidase confers radioresistance to glioblastoma cells

Ninh B. Doan, Ha S. Nguyen, Mona M. Al-Gizawiy, Wade M. Mueller, Roger A. Sabbadini, Scott D. Rand, Jennifer M. Connelly, Christopher R. Chitambar, Kathleen M. Schmainda, Shama P. Mirza
Pages: 1932-1940
Published online on: 28 July 2017

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Article Open Access

Potential role of ZEB1 as a DNA repair regulator in colorectal cancer cells revealed by cancer-associated promoter profiling

Miao Wang, Su-Fei He, Lei-Lei Liu, Xiao-Xia Sun, Fan Yang, Qian Ge, Wei-Kang Wong, Jing-Yan Meng
Pages: 1941-1948
Published online on: 08 August 2017

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Article Open Access

Atelocollagen-mediated in vivo siRNA transfection in ovarian carcinoma is influenced by tumor site, siRNA target and administration route

Matthieu Meryet-Figuière, Charlotte Lecerf, Emilie Varin, Jean-Luc Coll, Marie-Hélène Louis, Soizic Dutoit, Florence Giffard, Cécile Blanc-Fournier, Siham Hedir, Nicolas Vigneron, Emilie Brotin, Laurent Pelletier, Véronique Josserand, Christophe Denoyelle, Laurent Poulain
Pages: 1949-1958
Published online on: 04 August 2017

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Article Open Access

Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis

Jian Wang, Ke Liu, Xiao-Feng Wang, Dian-Jun Sun
Pages: 1959-1966
Published online on: 03 August 2017

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Article Open Access

TRPM7 is overexpressed in bladder cancer and promotes proliferation, migration, invasion and tumor growth

Sheng-Lin Gao, Chui-Ze Kong, Zhe Zhang, Ze-Liang Li, Jian-Bin Bi, Xian-Kui Liu
Pages: 1967-1976
Published online on: 07 August 2017

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Article Open Access

miR-187 inhibits the growth of cervical cancer cells by targeting FGF9 Retraction in /10.3892/or.2023.8632

Hua Liang, Ruoyu Luo, Xiaoqi Chen, Yuzi Zhao, Aili Tan
Pages: 1977-1984
Published online on: 23 August 2017

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Article Open Access

TP63 mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear

Paola Monti, Paola Ghiorzo, Paola Menichini, Giorgia Foggetti, Paola Queirolo, Alberto Izzotti, Gilberto Fronza
Pages: 1985-1994
Published online on: 14 August 2017

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Article Open Access

Downregulation of microRNA-15a suppresses the proliferation and invasion of renal cell carcinoma via direct targeting of eIF4E

Gang Li, Tie Chong, Xiaolong Xiang, Jie Yang, Hongliang Li
Pages: 1995-2002
Published online on: 11 August 2017

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Article Open Access

Tumor-associated macrophages induce the expression of FOXQ1 to promote epithelial-mesenchymal transition and metastasis in gastric cancer cells

Jian Guo, Yan Yan, Yu Yan, Qinyue Guo, Mingxin Zhang, Jia Zhang, David Goltzman
Pages: 2003-2010
Published online on: 03 August 2017

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Article Open Access

Silencing Aurora A leads to re-sensitization of breast cancer cells to Taxol through downregulation of SRC-mediated ERK and mTOR pathways

Yan Li, Wanqi Zhou, Ke Tang, Xiaoguang Chen, Zhiqiang Feng, Jindong Chen
Pages: 2011-2022
Published online on: 14 August 2017

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Article Open Access

Upregulation of GNL3 expression promotes colon cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway

Xi Tang, Lang Zha, Hui Li, Gang Liao, Zhen Huang, Xudong Peng, Ziwei Wang
Pages: 2023-2032
Published online on: 25 August 2017

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Article Open Access

IL‑33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-κB pathway

Jian-Fei Zhang, Peng Wang, Yu-Jin Yan, Yong Li, Min-Wu Guan, Jin-Jun Yu, Xin-Dong Wang
Pages: 2033-2042
Published online on: 25 August 2017

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Article Open Access

Identification of hub genes, key miRNAs and potential molecular mechanisms of colorectal cancer

Shasha Wu, Feixiang Wu, Zheng Jiang
Pages: 2043-2050
Published online on: 29 August 2017

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Article Open Access

MicroRNA-218 promotes cisplatin resistance in oral cancer via the PPP2R5A/Wnt signaling pathway

Zehang Zhuang, Fengchun Hu, Jing Hu, Cheng Wang, Jinsong Hou, Zhiqiang Yu, Tony T. Wang, Xiqiang Liu, Hongzhang Huang
Pages: 2051-2061
Published online on: 11 August 2017

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Article Open Access

WRAP53β, survivin and p16INK4a expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer

Katharina Tiefenböck-Hansson, Aaro Haapaniemi, Lovisa Farnebo, Björn Palmgren, Jussi Tarkkanen, Marianne Farnebo, Eva Munck-Wikland, Antti Mäkitie, Stina Garvin, Karin Roberg
Pages: 2062-2068
Published online on: 11 August 2017

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Article Open Access

FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1

Qiangsheng Hu, Yi Qin, Bo Zhang, Chen Liang, Shunrong Ji, Si Shi, Wenyan Xu, Jinfeng Xiang, Dingkong Liang, Quanxing Ni, Xianjun Yu, Jin Xu
Pages: 2069-2077
Published online on: 28 July 2017

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Article Open Access

MicroRNA-616 promotes the growth and metastasis of non-small cell lung cancer by targeting SOX7 Retraction in /10.3892/or.2023.8623

Danping Wang, Qifeng Cao, Meijun Qu, Zhaoqun Xiao, Minghui Zhang, Songbo Di
Pages: 2078-2086
Published online on: 28 July 2017

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Article Open Access

Zhi Zhen Fang formula reverses Hedgehog pathway mediated multidrug resistance in colorectal cancer

Hua Sui, Peiwen Duan, Piaoting Guo, Lishuang Hao, Xuan Liu, Jinhua Zhang, Huirong Zhu, Miaomiao Zhao, Hao Wang, Qi Li, Songpo Wang
Pages: 2087-2095
Published online on: 23 August 2017

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Article Open Access

miR-198-induced upregulation of Livin may be associated with the prognosis and contribute to the oncogenesis of lung adenocarcinoma

Yicheng Liang, Hetan Wang, Yuanyuan Sun, Sheng Chen, Haoyou Wang, Rong Huang, Xinyi Zhao, Weineng Fu, Chunlu Yang
Pages: 2096-2104
Published online on: 01 August 2017

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Article Open Access

Exogenous lipids promote the growth of breast cancer cells via CD36

Jing Zhao, Zheng Zhi, Chao Wang, Hanying Xing, Guangyao Song, Xian Yu, Yajun Zhu, Xing Wang, Xuemei Zhang, Yan Di
Pages: 2105-2115
Published online on: 01 August 2017

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Article Open Access

Downregulation of BZW2 inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway

Dong-Dong Cheng, Shi-Jie Li, Bin Zhu, Ting Yuan, Qing-Cheng Yang, Cun-Yi Fan
Pages: 2116-2122
Published online on: 08 August 2017

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Article Open Access

Sanggenon C induces apoptosis of colon cancer cells via inhibition of NO production, iNOS expression and ROS activation of the mitochondrial pathway

Li-Dong Chen, Zhi-Hui Liu, Lian-Feng Zhang, Jian-Ning Yao, Chun-Feng Wang
Pages: 2123-2131
Published online on: 22 August 2017

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Article Open Access

Killing effect of methionine enkephalin on melanoma in vivo and in vitro

Dong-Mei Wang, Xue Jiao, Nicolas P. Plotnikoff, Noreen Griffin, Rui-Qun Qi, Xing-Hua Gao, Feng-Ping Shan
Pages: 2132-2140
Published online on: 24 August 2017

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Article Open Access

Benzo(a)pyrene enhances the EMT-associated migration of lung adenocarcinoma A549 cells by upregulating Twist1

Xi Chen, Hongbing Peng, Jian Xiao, Anqi Guan, Bin Xie, Bixiu He, Qiong Chen
Pages: 2141-2147
Published online on: 03 August 2017

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Article Open Access

Downregulation of microRNA-196a inhibits human liver cancer cell proliferation and invasion by targeting FOXO1

Liu Yang, Fei Peng, Jian Qin, Henghua Zhou, Bing Wang
Pages: 2148-2154
Published online on: 03 August 2017

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Article Open Access

MicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1

Yu Shuang, Chao Li, Xuan Zhou, Yongwang Huang, Lun Zhang
Pages: 2155-2165
Published online on: 03 August 2017

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Article Open Access

Knockdown of RRS1 by lentiviral-mediated RNAi promotes apoptosis and suppresses proliferation of human hepatocellular carcinoma cells

Jitao Wang, Zhi Li, Changzeng Zuo, Qingfan Xie, Hui Li, Junhong Jia, Zhongguang Zhen, Ruizhao Qi, Zhiwei Li, Dengxiang Liu, Baijun Sun
Pages: 2166-2172
Published online on: 14 August 2017

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Article Open Access

MicroRNA-144-3p suppresses tumor growth and angiogenesis by targeting SGK3 in hepatocellular carcinoma

Manya Wu, Chaoyuan Huang, Xinping Huang, Rong Liang, Yan Feng, Xiaoling Luo
Pages: 2173-2181
Published online on: 11 August 2017

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Article Open Access

Upregulated exosomic miR‑23b‑3p plays regulatory roles in the progression of pancreatic cancer

Dayang Chen, Xiongbo Wu, Min Xia, Fang Wu, Junli Ding, Yang Jiao, Qiang Zhan, Fangmei An
Pages: 2182-2188
Published online on: 24 August 2017

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Article

The mechanism of de novo expression of programmed cell death-ligand 1 in squamous cell carcinoma of the lung

Tomoyuki Igarashi, Koji Teramoto, Mitsuaki Ishida, Jun Hanaoka, Yataro Daigo
Pages: 2189-2196
Published online on: 03 August 2017

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Article

STAT3 inhibition by WP1066 suppresses the growth and invasiveness of bladder cancer cells

Yujiro Tsujita, Akio Horiguchi, Shinsuke Tasaki, Makoto Isono, Takako Asano, Keiichi Ito, Tomohiko Asano, Yoshine Mayumi, Toshihiro Kushibiki
Pages: 2197-2204
Published online on: 11 August 2017

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Article

FGF8 promotes cell proliferation and resistance to EGFR inhibitors via upregulation of EGFR in human hepatocellular carcinoma cells

Yuanmin Pei, Xueling Sun, Xiwei Guo, Huashan Yin, Le Wang, Fugu Tian, Hongxi Jing, Xiaobo Liang, Jun Xu, Pengcheng Shi
Pages: 2205-2210
Published online on: 07 August 2017

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Article

Pseudolaric acid B inhibits neuroglioma cell proliferation through DNA damage response

Fengmei Song, Xiaoyan Yu, Haipeng Zhang, Zengyan Wang, Yue Wang, Xiangling Meng, Jinghua Yu
Pages: 2211-2218
Published online on: 01 August 2017

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Article

Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis

Jilong Guo, Guohua Gong, Bin Zhang
Pages: 2219-2228
Published online on: 21 August 2017

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Article

Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma

Yonghao Liang, Qisheng Li, Keli Chen, Wen Ni, Zetao Zhan, Feng Ye, Yiyi Li, Yuan Fang, Fengjiao Zhang, Longhua Chen, Yi Ding
Pages: 2229-2236
Published online on: 01 August 2017

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Article

A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect

Masahiro Uchibori, Ken-Ichi Aoyama, Yoshihide Ota, Kagemasa Kajiwara, Masafumi Tanaka, Minoru Kimura
Pages: 2237-2242
Published online on: 03 August 2017

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Article

MicroRNA-212 functions as a tumor-suppressor in human non-small cell lung cancer by targeting SOX4

Tingting Tang, Liting Huan, Shujuan Zhang, Hui Zhou, Lei Gu, Xiaohui Chen, Liang Zhang
Pages: 2243-2250
Published online on: 07 August 2017

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Article

EVI5 is a novel independent prognostic predictor in hepatocellular carcinoma after radical hepatectomy

Jintian Tang, Jianghua Ou, Chunyan Xu, Chao Yi, Feng Xue, Lin Xu, Fenju Lai, Jianjun Tang, Shengping Li, Tiebang Kang, Wei Ding, Boqing Wang
Pages: 2251-2258
Published online on: 01 August 2017

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Article

Preclinical evaluation of cisplatin-incorporated bio-nanocapsules as chemo-radiotherapy for human hepatocellular carcinoma

Seol Hwa Shin, Seok Soon Park, Kyoung Jin Lee, Eun Jin Ju, Jin Park, Eun Jeong Ko, Joohee Jung, Shun'ich Kuroda, Seung-Mo Hong, Jung Jin Hwang, Jung Shin Lee, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Choi
Pages: 2259-2266
Published online on: 21 August 2017

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Article

Tetramethylpyrazine suppresses lipid accumulation in macrophages via upregulation of the ATP-binding cassette transporters and downregulation of scavenger receptors

Jie Duan, Dong Xiang, Hongli Luo, Guojun Wang, Yun Ye, Chao Yu, Xiuying Li
Pages: 2267-2276
Published online on: 04 August 2017

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Article

Chemotherapy enhances programmed cell death 1/ligand 1 expression via TGF-β induced epithelial mesenchymal transition in non-small cell lung cancer

Soichiro Funaki, Yasushi Shintani, Tomohiro Kawamura, Ryu Kanzaki, Masato Minami, Meinoshin Okumura
Pages: 2277-2284
Published online on: 09 August 2017

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Article

FTO expression is associated with the occurrence of gastric cancer and prognosis

Dong Xu, Weiwei Shao, Yasu Jiang, Xi Wang, Ying Liu, Xianchen Liu
Pages: 2285-2292
Published online on: 14 August 2017

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Article

Scutellaria barbata D. Don inhibits 5-fluorouracil resistance in colorectal cancer by regulating PI3K/AKT pathway

Jiumao Lin, Jianyu Feng, Hong Yang, Zhaokun Yan, Qiongyu Li, Lihui Wei, Zijun Lai, Yiyi Jin, Jun Peng
Pages: 2293-2300
Published online on: 09 August 2017

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Article

ABT-737 potentiates cisplatin-induced apoptosis in human osteosarcoma cells via the mitochondrial apoptotic pathway

Fengtian Zhang, Xiaolong Yu, Xuqiang Liu, Tonghua Zhou, Tao Nie, Ming Cheng, Hucheng Liu, Min Dai, Bin Zhang
Pages: 2301-2308
Published online on: 14 August 2017

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Article

Functional expression, characterization, and application of human S100B

Lei Wu, Xuesi Zhou, Zhigang Xiao, Xiujie Gao, Ziquan Liu, Zhiqing Zhang, Kun Wang, Yulin Zhu, Hanlin Ren, Tianhui Wang
Pages: 2309-2316
Published online on: 24 August 2017

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Article

Smad4 re-expression increases the sensitivity to parthenolide in colorectal cancer

Xuemei Li, Huike Yang, Jia Ke, Baoquan Liu, Xiaohong Lv, Xinlei Li, Yafang Zhang
Pages: 2317-2324
Published online on: 29 August 2017

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Article

EGF-induced urokinase plasminogen activator receptor promotes epithelial to mesenchymal transition in human gastric cancer cells

Pingping Wang, Maoyuan Ma, Shanhui Zhang
Pages: 2325-2334
Published online on: 24 August 2017

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Article

Combined analysis of ChIP-seq and gene microarray datasets identify the E2-mediated genes in ERα-dependent manner in osteosarcoma

Kangsong Tian, Wei Qi, Qian Yan, Feng Zhang, Delei Song, Haiyang Zhang, Ming Lv
Pages: 2335-2342
Published online on: 22 August 2017

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Article

A novel chalcone-based molecule, BDP inhibits MDA‑MB‑231 triple-negative breast cancer cell growth by suppressing Hsp90 function

Yong Jin Oh, Young Ho Seo
Pages: 2343-2350
Published online on: 25 August 2017

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Article

miR-217 targeting DKK1 promotes cancer stem cell properties via activation of the Wnt signaling pathway in hepatocellular carcinoma

Chunlin Jiang, Miao Yu, Xiaoyan Xie, Guangliang Huang, Yao Peng, Dong Ren, Manxia Lin, Baoxian Liu, Ming Liu, Wei Wang, Ming Kuang
Pages: 2351-2359
Published online on: 25 August 2017

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Article

Betulinic acid increases radiosensitization of oral squamous cell carcinoma through inducing Sp1 sumoylation and PTEN expression

Dao-Ying Yuan, Zhen Meng, Kai Xu, Qiao-Feng Li, Cheng Chen, Ke-Yi Li, Bin Zhang
Pages: 2360-2368
Published online on: 03 August 2017

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Article

MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma

Jian Wu, Dawei Zhang, Jun Li, Xin Deng, Guannan Liang, Yang Long, Xuemei He, Tianyang Dai, Delian Ren
Pages: 2369-2377
Published online on: 08 August 2017

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Article

RUNX3 plays a tumor suppressor role by inhibiting cell migration, invasion and angiogenesis in oral squamous cell carcinoma

Wei-Na Zhou, Yi-Fei Du, Jin Bai, Xiao-Meng Song, Yang Zheng, Hua Yuan, Wei Zhang, Zheng-Dong Zhang, Yu-Nong Wu
Pages: 2378-2386
Published online on: 31 July 2017

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Article

EGFR gene status predicts response and survival benefit in a preclinical gastric cancer trial treating patient‑derived xenografts with cetuximab

Xiaohong Wang, Runjia Fu, Ying Hu, Hong Du, Shuangxi Li, Ziyu Li, Yiqiang Liu, Qixiang Li, Lianhai Zhang, Jiafu Ji
Pages: 2387-2393
Published online on: 14 August 2017

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Article

Low co-expression of epidermal growth factor receptor and its chaperone heat shock protein 90 is associated with worse prognosis in primary glioblastoma, IDH-wild-type

Elsa Sartori, Rupert Langer, Erik Vassella, Ekkehard Hewer, Philippe Schucht, Inti Zlobec, Sabina Berezowska
Pages: 2394-2400
Published online on: 01 August 2017

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Article

miR-93 and PTEN: Key regulators of doxorubicin-resistance and EMT in breast cancer

Shihua Chu, Geng Liu, Peixuan Xia, Guoqing Chen, Feng Shi, Tao Yi, Hongying Zhou
Pages: 2401-2407
Published online on: 31 July 2017

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Article

Long non-coding RNA MEG3 inhibits cell growth of gliomas by targeting miR-93 and inactivating PI3K/AKT pathway Retraction in /10.3892/or.2020.7828

Ling Zhang, Xin Liang, Yuxiong Li
Pages: 2408-2416
Published online on: 03 August 2017

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Attenuation of MUC4 potentiates the anticancer activity of auranofin via regulation of the Her2/Akt/FOXO3 pathway in ovarian cancer cells

Jun Sang Bae, Jongsung Lee, Yoonkook Park, Kyungmoon Park, Jung Ryul Kim, Dong Hyu Cho, Kyu Yun Jang, See-Hyoung Park
Pages: 2417-2425
Published online on: 28 July 2017

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Article

B7-H3 is related to tumor progression in ovarian cancer

Jingjing Zhang, Lu Liu, Sai Han, Yi Li, Qiuhong Qian, Qianqian Zhang, Hui Zhang, Ziyan Yang, Youzhong Zhang
Pages: 2426-2434
Published online on: 31 July 2017

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MicroRNA-1297 contributes to tumor growth of human breast cancer by targeting PTEN/PI3K/AKT signaling Retraction in /10.3892/or.2023.8617

Chao Liu, Zhikui Liu, Xiao Li, Xiaojiang Tang, Jianjun He, Shaoying Lu
Pages: 2435-2443
Published online on: 07 August 2017

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Article

HSP47 is associated with the prognosis of laryngeal squamous cell carcinoma by inhibiting cell viability and invasion and promoting apoptosis

Xiaoxiao Song, Zhisu Liao, Chunchun Zhou, Renyu Lin, Jianglong Lu, Lin Cai, Xiaohua Tan, Wenjian Zeng, Xianghe Lu, Weiming Zheng, Jianfu Chen, Zhipeng Su
Pages: 2444-2452
Published online on: 09 August 2017

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Article

Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression

Jing Sui, Ru-Song Yang, Si-Yi Xu, Yan-Qiu Zhang, Cheng-Yun Li, Sheng Yang, Li-Hong Yin, Yue-Pu Pu, Ge-Yu Liang
Pages: 2453-2463
Published online on: 04 August 2017

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Article

Corilagin sensitizes epithelial ovarian cancer to chemotherapy by inhibiting Snail‑glycolysis pathways

Luoqi Jia, Jiayi Zhou, Hongbo Zhao, Hongyan Jin, Minzhi Lv, Naiqing Zhao, Zhizhong Zheng, Yiling Lu, Yanlin Ming, Yinhua Yu
Pages: 2464-2470
Published online on: 07 August 2017

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Article

Knockdown of c‑Myc activates Fas-mediated apoptosis and sensitizes A549 cells to radiation

Jing Zhang, Ling Zhou, Zhaodi Nan, Qing Yuan, Jie Wen, Maolei Xu, Youjie Li, Baosheng Li, Pingyu Wang, Changmin Liu, Ying Ma, Shaoshui Chen, Shuyang Xie
Pages: 2471-2479
Published online on: 10 August 2017

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Article

Knockdown of tripartite motif-59 inhibits the malignant processes in human colorectal cancer cells

Wei Wu, Jingdi Chen, Jicheng Wu, Jun Lin, Sheng Yang, Honggang Yu
Pages: 2480-2488
Published online on: 10 August 2017

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Article

Chaetocin induces cell cycle arrest and apoptosis by regulating the ROS-mediated ASK-1/JNK signaling pathways

Jingliang He, Xiaoxun Chen, Bowei Li, Wenjie Zhou, Jinfeng Xiao, Ke He, Jinqian Zhang, Guoan Xiang
Pages: 2489-2497
Published online on: 24 August 2017

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Article

c‑Myc promotes cholangiocarcinoma cells to overcome contact inhibition via the mTOR pathway

Guosong Luo, Bin Li, Chunyan Duan, Ying Cheng, Bin Xiao, Fuli Yao, Mei Wei, Qinghua Tao, Chunhong Feng, Xianming Xia, Hong Zhou, Xiaofang Zhao, Rongyang Dai
Pages: 2498-2506
Published online on: 22 August 2017

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Article

Aspirin inhibits the proliferation of human uterine leiomyoma cells by downregulation of K‑Ras‑p110α interaction

Min Gao, Kai-Min Guo, Ying-Mei Wei, Ming-Ming Ma, Jia-Rong Cai, Ting-Ting Xia, Qing-Jian Ye
Pages: 2507-2517
Published online on: 22 August 2017

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Article

Daidzein inhibits choriocarcinoma proliferation by arresting cell cycle at G1 phase through suppressing ERK pathway in vitro and in vivo

Wei Zheng, Rong Sun, Lei Yang, Xianling Zeng, Yan Xue, Ruifang An
Pages: 2518-2524
Published online on: 28 August 2017

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Article

Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells

Lívia Paes Tavares Pacheco Guimarães, Gleice da Graça Rocha, Rafaela Muniz Queiroz, Carollina Araujo Martins, Christina Maeda Takiya, Cerli Rocha Gattass
Pages: 2525-2534
Published online on: 10 August 2017

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Article

Complex analysis of the TP53 tumor suppressor in mantle cell and diffuse large B-cell lymphomas

Lenka Zlamalikova, Mojmir Moulis, Barbora Ravcukova, Kvetoslava Liskova, Jitka Malcikova, David Salek, Jiri Jarkovsky, Miluse Svitakova, Renata Hrabalkova, Jan Smarda, Jana Smardova
Pages: 2535-2542
Published online on: 08 August 2017

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Article

A decrease in ubiquitination and resulting prolonged life-span of KIT underlies the KIT overexpression-mediated imatinib resistance of KIT mutation-driven canine mast cell tumor cells

Masato Kobayashi, Shiori Kuroki, Sena Kurita, Ryo Miyamoto, Hiroyuki Tani, Kyoichi Tamura, Makoto Bonkobara
Pages: 2543-2550
Published online on: 01 August 2017

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Article

Wild-type p53 controls the level of fibronectin expression in breast cancer cells

Daeun You, Seung Pil Jung, Yisun Jeong, Soo Youn Bae, Sangmin Kim
Pages: 2551-2557
Published online on: 31 July 2017

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Article

Cepharanthine hydrochloride reverses P‑glycoprotein-mediated multidrug resistance in human ovarian carcinoma A2780/Taxol cells by inhibiting the PI3K/Akt signaling pathway

Chen-Zheng Huang, Ya-Feng Wang, Yan Zhang, You-Mei Peng, Yi-Xian Liu, Fang Ma, Jin-Hua Jiang, Qing-Duan Wang
Pages: 2558-2564
Published online on: 04 August 2017

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Article

Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139

Li Yang, Dian Yin, Yilang Wang , Lili Cao
Pages: 2565-2571
Published online on: 02 August 2017

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Article

Inhibition of NOB1 by microRNA-330-5p overexpression represses cell growth of non-small cell lung cancer

Ranran Kong, Wei Liu, Yurui Guo, Jie Feng, Chuantao Cheng, Xinwu Zhang, Yuefeng Ma, Shaomin Li, Jiantao Jiang, Jin Zhang, Zhe Qiao, Jie Qin, Teng Lu, Xijing He
Pages: 2572-2580
Published online on: 28 August 2017

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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