Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells

  • Authors:
    • Lívia Paes Tavares Pacheco Guimarães
    • Gleice da Graça Rocha
    • Rafaela Muniz Queiroz
    • Carollina Araujo Martins
    • Christina Maeda Takiya
    • Cerli Rocha Gattass
  • View Affiliations

  • Published online on: August 10, 2017     https://doi.org/10.3892/or.2017.5895
  • Pages: 2525-2534
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Abstract

Glioblastoma (GBM), the most aggressive of primary brain tumors, determine short survival and poor quality of life. Therapies used for its treatment are not effective and chemotherapy failure is partially due to multidrug resistance (MDR) mechanisms present in the tumor cells. New therapeutic strategies are needed in order to improve survival in GBM. The present study investigated the activity of the pentacyclic triterpene pomolic acid (PA) in GBM. Pomolic acid decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation. It also induced uncoupling of mitochondria membrane potential and activation of caspase-3 and -9. Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production as it is inhibited by anti-oxidant treatment. Pomolic acid also down-modulated the activity of the multidrug resistance associated protein 1 (MRP1) and inhibited migration of GBM cells. These results show that PA acts on several pathways of GBM drug resistance and therefore may be of potential interest for the treatment of this tumor.
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October-2017
Volume 38 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Guimarães LT, Rocha Gd, Queiroz RM, Martins CA, Takiya CM and Gattass CR: Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells. Oncol Rep 38: 2525-2534, 2017
APA
Guimarães, L.T., Rocha, G.d., Queiroz, R.M., Martins, C.A., Takiya, C.M., & Gattass, C.R. (2017). Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells. Oncology Reports, 38, 2525-2534. https://doi.org/10.3892/or.2017.5895
MLA
Guimarães, L. T., Rocha, G. d., Queiroz, R. M., Martins, C. A., Takiya, C. M., Gattass, C. R."Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells". Oncology Reports 38.4 (2017): 2525-2534.
Chicago
Guimarães, L. T., Rocha, G. d., Queiroz, R. M., Martins, C. A., Takiya, C. M., Gattass, C. R."Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells". Oncology Reports 38, no. 4 (2017): 2525-2534. https://doi.org/10.3892/or.2017.5895