Open Access

Predicting radiotherapy response for patients with soft tissue sarcoma by developing a molecular signature

  • Authors:
    • Zaixiang Tang
    • Qinghua Zeng
    • Yan Li
    • Xinyan Zhang
    • Mark J. Suto
    • Bo Xu
    • Nengjun Yi
  • View Affiliations

  • Published online on: September 25, 2017     https://doi.org/10.3892/or.2017.5999
  • Pages: 2814-2824
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Soft tissue sarcomas are rare and aggressive tumors arising from connective tissues. Adjuvant radiotherapy is a commonly used treatment approach for the majority of sarcomas. We attempted to identify a gene signature that can predict radiosensitive patients who are most likely to have a better treatment response from radiotherapy, compared with disease progression. Using the publicly available data of soft tissue sarcoma from The Cancer Genome Atlas, we developed a cross-validation procedure to identify a predictive gene signature for radiosensitivity. The results showed that the predicted radiosensitive patients who received radiotherapy had significantly improved treatment response. We further provide supportive evidence to validate our sensitivity prediction. Results showed that the predicted radiosensitive patients who received radiotherapy had significantly improved survival than patients who did not. ROC analysis showed that the developed gene signature had a powerful prediction on treatment response. We further found that predicted radiosensitive patients who received radiotherapy had a significantly reduced rate of new tumor events. Finally, we validated our gene signature using a hierarchical cluster analysis, and found that the predicted sensitivities were well-matched with results from the cluster analysis. These results are consistent with our expectation, suggesting that the identified gene signature and radiosensitivity prediction are effective. The genes involved in the signature may provide a molecular basis for prognostic studies and radiotherapy target discovery.
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November-2017
Volume 38 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Tang Z, Zeng Q, Li Y, Zhang X, Suto MJ, Xu B and Yi N: Predicting radiotherapy response for patients with soft tissue sarcoma by developing a molecular signature. Oncol Rep 38: 2814-2824, 2017
APA
Tang, Z., Zeng, Q., Li, Y., Zhang, X., Suto, M.J., Xu, B., & Yi, N. (2017). Predicting radiotherapy response for patients with soft tissue sarcoma by developing a molecular signature. Oncology Reports, 38, 2814-2824. https://doi.org/10.3892/or.2017.5999
MLA
Tang, Z., Zeng, Q., Li, Y., Zhang, X., Suto, M. J., Xu, B., Yi, N."Predicting radiotherapy response for patients with soft tissue sarcoma by developing a molecular signature". Oncology Reports 38.5 (2017): 2814-2824.
Chicago
Tang, Z., Zeng, Q., Li, Y., Zhang, X., Suto, M. J., Xu, B., Yi, N."Predicting radiotherapy response for patients with soft tissue sarcoma by developing a molecular signature". Oncology Reports 38, no. 5 (2017): 2814-2824. https://doi.org/10.3892/or.2017.5999