Genome-wide study of ER-regulated lncRNAs shows AP000439.3 may function as a key regulator of cell cycle in breast cancer

  • Authors:
    • Yin Zhang
    • Dan-Lan Wang
    • Hai-Yan Yan
    • Jian-You Liao
    • Jie-Hua He
    • Kai-Shun Hu
    • Wei-Xi Deng
    • Yan-Jie Wang
    • Hong-Tao Xing
    • H. Phillip Koeffler
    • Dong Yin
  • View Affiliations

  • Published online on: September 20, 2017     https://doi.org/10.3892/or.2017.5975
  • Pages: 3227-3237
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Abstract

Estrogen receptor (ER) plays important roles in cell growth, development and tumorigenesis. Although ER-regulated genes have been extensively investigated, little is known about roles of ER-regulated lncRNAs in breast cancer. Here, we conducted genome-wide study of ER-regulated lncRNAs by using RNA-seq, ChIP-seq and TCGA data. A total of identified 114 ER-regulated lncRNAs were identified, many of them were overexpressed in ER+ breast cancer and co-expressed with some key regulators. Silencing one of most prominent lncRNA, AP000439.3, resulted in inhibition of cell cycle progression and proliferation. Further study revealed AP000439.3 can regulate expression of CCND1 through enhancing estrogen receptor induction of CCND1. This finding revealed lncRNAs may serve as important effectors of ER in regulation of gene expression and cell phenotype in breast cancer.
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November-2017
Volume 38 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Y, Wang D, Yan H, Liao J, He J, Hu K, Deng W, Wang Y, Xing H, Koeffler HP, Koeffler HP, et al: Genome-wide study of ER-regulated lncRNAs shows AP000439.3 may function as a key regulator of cell cycle in breast cancer. Oncol Rep 38: 3227-3237, 2017
APA
Zhang, Y., Wang, D., Yan, H., Liao, J., He, J., Hu, K. ... Yin, D. (2017). Genome-wide study of ER-regulated lncRNAs shows AP000439.3 may function as a key regulator of cell cycle in breast cancer. Oncology Reports, 38, 3227-3237. https://doi.org/10.3892/or.2017.5975
MLA
Zhang, Y., Wang, D., Yan, H., Liao, J., He, J., Hu, K., Deng, W., Wang, Y., Xing, H., Koeffler, H. P., Yin, D."Genome-wide study of ER-regulated lncRNAs shows AP000439.3 may function as a key regulator of cell cycle in breast cancer". Oncology Reports 38.5 (2017): 3227-3237.
Chicago
Zhang, Y., Wang, D., Yan, H., Liao, J., He, J., Hu, K., Deng, W., Wang, Y., Xing, H., Koeffler, H. P., Yin, D."Genome-wide study of ER-regulated lncRNAs shows AP000439.3 may function as a key regulator of cell cycle in breast cancer". Oncology Reports 38, no. 5 (2017): 3227-3237. https://doi.org/10.3892/or.2017.5975