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Downregulation of miR-874-3p promotes chemotherapeutic resistance in colorectal cancer via inactivation of the Hippo signaling pathway

  • Authors:
    • Kaiqian Que
    • Yuanhe Tong
    • Ganbo Que
    • Li Li
    • Hongcheng Lin
    • Shuai Huang
    • Ruoyu Wang
    • Langlang Tang

  • View Affiliations

  • Published online on: October 17, 2017     https://doi.org/10.3892/or.2017.6041
  • Pages: 3376-3386

  • Copyright: © Que et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Overcoming resistance to chemotherapy is an arduous challenge in the treatment of colorectal cancer (CRC), particularly since the underlying molecular mechanisms remain obscure. In the present study, we reported that miR‑874-3p was markedly downregulated in CRC tissues compared with that in adjacent normal colorectal epithelial tissues. Upregulation of miR-874-3p attenuated the chemoresistance of CRC cells to 5-fluorouracil (5-FU) in vitro and in vivo. Conversely, inhibition of miR-874-3p yielded an opposite effect. Furthermore, our results demonstrated that miR-874-3p directly inhibited the expression of transcriptional co-activators YAP and TAZ of the Hippo signaling pathway, resulting in the inactivation of the TEAD transcription. Thus, our findings clarify a novel mechanism by which miR-874-3p restores chemotherapeutic sensitivity of CRC to 5-FU, indicating that offering miR-874-3p mimics in combination with 5-FU may serve as a new therapeutic strategy to circumvent the chemoresistance in CRC.
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December-2017
Volume 38 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Que K, Tong Y, Que G, Li L, Lin H, Huang S, Wang R and Tang L: Downregulation of miR-874-3p promotes chemotherapeutic resistance in colorectal cancer via inactivation of the Hippo signaling pathway. Oncol Rep 38: 3376-3386, 2017
APA
Que, K., Tong, Y., Que, G., Li, L., Lin, H., Huang, S. ... Tang, L. (2017). Downregulation of miR-874-3p promotes chemotherapeutic resistance in colorectal cancer via inactivation of the Hippo signaling pathway. Oncology Reports, 38, 3376-3386. https://doi.org/10.3892/or.2017.6041
MLA
Que, K., Tong, Y., Que, G., Li, L., Lin, H., Huang, S., Wang, R., Tang, L."Downregulation of miR-874-3p promotes chemotherapeutic resistance in colorectal cancer via inactivation of the Hippo signaling pathway". Oncology Reports 38.6 (2017): 3376-3386.
Chicago
Que, K., Tong, Y., Que, G., Li, L., Lin, H., Huang, S., Wang, R., Tang, L."Downregulation of miR-874-3p promotes chemotherapeutic resistance in colorectal cancer via inactivation of the Hippo signaling pathway". Oncology Reports 38, no. 6 (2017): 3376-3386. https://doi.org/10.3892/or.2017.6041