Suppressive role of miR-592 in breast cancer by repressing TGF-β2

Hou,Wenli; Zhang,Haipeng; Bai,Xiaoxue; Liu,Xiaofeng; Yu,Yunhe; Song,Lelian; Du,Ye

doi:10.3892/or.2017.6029

Suppressive role of miR-592 in breast cancer by repressing TGF-β2

Authors:
- Wenli Hou
- Haipeng Zhang
- Xiaoxue Bai
- Xiaofeng Liu
- Yunhe Yu
- Lelian Song
- Ye Du
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Affiliations: Department of Cadre Ward, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China, Department of Gynecology, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China, Tanslational Medicine Research Institute, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China, Department of Breast Surgery, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China
Published online on: October 12, 2017 https://doi.org/10.3892/or.2017.6029
Pages: 3447-3454

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Abstract

The function of miR-592 has been investigated in many types of cancer, however its roles in breast cancer remain unclear. We therefore investigated the biological function and underlying mechanism of miR-592 in breast cancer. In the present study, a marked downregulation of miR-592 was observed in breast cancer tissues and cell lines compared to the matched adjacent non-tumor tissues and normal breast cell line. Statistical analysis revealed that decreased miR-592 was negatively associated with advanced clinical stage, distant metastasis and lymph node metastases. Function analysis demonstrated that overexpression of miR-592 significantly inhibited cell proliferation, clone formation, migration and invasion in breast cancer cells in vitro, as well as suppressed tumor growth in vivo. Furthermore, transforming growth factor β-2 (TGFβ-2), a known oncogene, was identified as a direct target of miR-592, and its mRNA expression level was inversely correlated with the expression level of miR-592 in human breast cancer specimens. Restoration of TGFβ-2 expression rescued the inhibitory effect in breast cancer cells caused by miR-592. Collectively, these data suggest that miR-592 may exert it suppressive role in breast cancer, at least in part, by targeting TGFβ-2, and that miR-592 may be a novel target for breast cancer treatment.

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