Suppressive role of miR-592 in breast cancer by repressing TGF-β2

  • Authors:
    • Wenli Hou
    • Haipeng Zhang
    • Xiaoxue Bai
    • Xiaofeng Liu
    • Yunhe Yu
    • Lelian Song
    • Ye Du
  • View Affiliations

  • Published online on: October 12, 2017     https://doi.org/10.3892/or.2017.6029
  • Pages:3447-3454
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Abstract

The function of miR-592 has been investigated in many types of cancer, however its roles in breast cancer remain unclear. We therefore investigated the biological function and underlying mechanism of miR-592 in breast cancer. In the present study, a marked downregulation of miR-592 was observed in breast cancer tissues and cell lines compared to the matched adjacent non-tumor tissues and normal breast cell line. Statistical analysis revealed that decreased miR-592 was negatively associated with advanced clinical stage, distant metastasis and lymph node metastases. Function analysis demonstrated that overexpression of miR-592 significantly inhibited cell proliferation, clone formation, migration and invasion in breast cancer cells in vitro, as well as suppressed tumor growth in vivo. Furthermore, transforming growth factor β-2 (TGFβ-2), a known oncogene, was identified as a direct target of miR-592, and its mRNA expression level was inversely correlated with the expression level of miR-592 in human breast cancer specimens. Restoration of TGFβ-2 expression rescued the inhibitory effect in breast cancer cells caused by miR-592. Collectively, these data suggest that miR-592 may exert it suppressive role in breast cancer, at least in part, by targeting TGFβ-2, and that miR-592 may be a novel target for breast cancer treatment.

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December 2017
Volume 38 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
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APA
Hou, W., Zhang, H., Bai, X., Liu, X., Yu, Y., Song, L., & Du, Y. (2017). Suppressive role of miR-592 in breast cancer by repressing TGF-β2. Oncology Reports, 38, 3447-3454. https://doi.org/10.3892/or.2017.6029
MLA
Hou, W., Zhang, H., Bai, X., Liu, X., Yu, Y., Song, L., Du, Y."Suppressive role of miR-592 in breast cancer by repressing TGF-β2". Oncology Reports 38.6 (2017): 3447-3454.
Chicago
Hou, W., Zhang, H., Bai, X., Liu, X., Yu, Y., Song, L., Du, Y."Suppressive role of miR-592 in breast cancer by repressing TGF-β2". Oncology Reports 38, no. 6 (2017): 3447-3454. https://doi.org/10.3892/or.2017.6029