miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclin D1/MMP2 axis

  • Authors:
    • Lijiang Zhao
    • Lijuan Liu
    • Zheng Dong
    • Jie Xiong
  • View Affiliations

  • Published online on: October 20, 2017     https://doi.org/10.3892/or.2017.6047
  • Pages:3522-3530
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Abstract

Valid evidence has demonstrated that microRNAs have critical functions in cancer genesis and tumor progression. In the present study, aberrant expression of microRNA-149 (miR-149) was confirmed in non-small cell lung cancer (NSCLC) tissues. Low expression of miR-149 was associated with malignant clinical features and poor survival. Gain- and loss-of-function experiments demonstrated that miR-149 inhibited NSCLC tumor growth and metastasis in vitro and in vivo. Furthermore, oncogenic transcription factor FOXM1 was confirmed as a direct target of miR-149 in NSCLC. Cyclin D1 and MMP2 served as downstream targets of FOXM1 and were also inhibited by miR-149. In summary, the present study indicated that downregulation of miR-149 in NSCLC predicted poor clinical outcomes. miR-149 suppresses tumor growth and metastasis in NSCLC by inhibiting the FOXM1/cyclin D1/MMP2 signaling pathway.

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December 2017
Volume 38 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
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APA
Zhao, L., Liu, L., Dong, Z., & Xiong, J. (2017). miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclin D1/MMP2 axis. Oncology Reports, 38, 3522-3530. https://doi.org/10.3892/or.2017.6047
MLA
Zhao, L., Liu, L., Dong, Z., Xiong, J."miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclin D1/MMP2 axis". Oncology Reports 38.6 (2017): 3522-3530.
Chicago
Zhao, L., Liu, L., Dong, Z., Xiong, J."miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclin D1/MMP2 axis". Oncology Reports 38, no. 6 (2017): 3522-3530. https://doi.org/10.3892/or.2017.6047