Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-κB/MMP-9 signaling in monomorphic malignant human glioma cells

  • Authors:
    • Wonil Lee
    • Jin Han Nam
    • Hyun-Ji Cho
    • Ju-Young Lee
    • Won-Kyung Cho
    • Υeongyeon Kim
    • Young-Man We
    • Jin Yeul Ma
    • Hyang-Sook Hoe
  • View Affiliations

  • Published online on: October 17, 2017     https://doi.org/10.3892/or.2017.6043
  • Pages:3619-3631
0

Abstract

Previously, we showed that the herbal extract EYK (Epimedium koreanum Nakai) can regulate the immune response. Other studies showed that EYK has beneficial effects in human lung cancer, angiogenesis and Alzheimer's disease (AD). However, it remains unknown whether EYK can affect cancer cell migration and invasion in human brain cancer cell lines. In the present study, we found that pre- or post-treatment with EYK inhibited phorbol 12-myristate 13-acetate (PMA)-induced cancer cell migration and invasion in A172 cells, but not in U373MG or T98G cells. Additionally, pre- or post-treatment with PMA followed by EYK decreased MMP-9 activity in A172 cells. Moreover, treatment with a NF-κB inhibitor significantly decreased cell migration in A172 cells pre- or post-treated with EYK and PMA, suggesting that EYK requires NF-κB to alter cancer cell migration. Either pre- or post-treatment with EYK significantly decreased NF-κB nuclear translocation in comparison with PMA treatment. Taken together, our results suggest that EYK suppresses PMA-induced cancer cell migration in monomorphic malignant human glioma cells by downregulating the NF-κB pathway and decreasing MMP-9 activity.

Related Articles

Journal Cover

December 2017
Volume 38 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Lee, W., Nam, J.H., Cho, H., Lee, J., Cho, W., Kim, Υ. ... Hoe, H. (2017). Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-κB/MMP-9 signaling in monomorphic malignant human glioma cells. Oncology Reports, 38, 3619-3631. https://doi.org/10.3892/or.2017.6043
MLA
Lee, W., Nam, J. H., Cho, H., Lee, J., Cho, W., Kim, Υ., We, Y., Ma, J. Y., Hoe, H."Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-κB/MMP-9 signaling in monomorphic malignant human glioma cells". Oncology Reports 38.6 (2017): 3619-3631.
Chicago
Lee, W., Nam, J. H., Cho, H., Lee, J., Cho, W., Kim, Υ., We, Y., Ma, J. Y., Hoe, H."Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-κB/MMP-9 signaling in monomorphic malignant human glioma cells". Oncology Reports 38, no. 6 (2017): 3619-3631. https://doi.org/10.3892/or.2017.6043