Open Access

IMP3 overexpression occurs in various important cancer types and is linked to aggressive tumor features: A tissue microarray study on 8,877 human cancers and normal tissues

  • Authors:
    • Christoph Burdelski
    • Nilofar Jakani-Karimi
    • Frank Jacobsen
    • Christina Möller-Koop
    • Sarah Minner
    • Ronald Simon
    • Guido Sauter
    • Stefan Steurer
    • Till S. Clauditz
    • Waldemar Wilczak
  • View Affiliations

  • Published online on: November 2, 2017     https://doi.org/10.3892/or.2017.6072
  • Pages:3-12
  • Copyright: © Burdelski et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

IMP3 is an RNA binding protein required for ribosomal RNA processing, which has been suggested to be a prognostic marker in a large variety of human types of cancer. However, available data on the prevalence of IMP3 expression are largely discrepant. To systematically investigate the epidemiology and clinical relevance of IMP3 expression in human cancers we employed a two-step tissue microarrays (TMAs) approach. First, a normal tissue TMA and a multi-tumor TMA were analyzed for immunohistochemically detectable expression of IMP3 in 76 different normal tissue types and 3889 cancer samples from 95 different tumor categories. In a second step, we searched for associations between IMP3 expression and tumor phenotype and patient prognosis in TMAs containing 697 urinary bladder cancers, 1711 colon cancers, 343 esophageal adenocarcinomas, 251 esophageal squamous cell cancers, 673 lung cancers), 275 pancreatic cancers and 230 stomach cancers. In normal tissues, unequivocal IMP3 expression was found in placenta, lymphocytes and some types of glandular epithelial cells. In cancers, at least one case with weak expression could be found in 76 out of 95 (80%) different tumor types and 64 entities (67%) had at least one tumor with strong positivity. IMP3 expression was most frequently found in testicular cancer (including 71% seminomas and 96% non-seminomas), neuroblastoma (88%), and squamous cell cancer of various origins. Significant associations were found between IMP3 and adverse tumor features in esophageal adenocarcinomas and cancers of the urinary bladder, lung, stomach, and pancreas. In summary, IMP3 was frequently expressed in many different tumor types, and was typically associated with aggressive tumor features.

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January 2018
Volume 39 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
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APA
Burdelski, C., Jakani-Karimi, N., Jacobsen, F., Möller-Koop, C., Minner, S., Simon, R. ... Wilczak, W. (2018). IMP3 overexpression occurs in various important cancer types and is linked to aggressive tumor features: A tissue microarray study on 8,877 human cancers and normal tissues. Oncology Reports, 39, 3-12. https://doi.org/10.3892/or.2017.6072
MLA
Burdelski, C., Jakani-Karimi, N., Jacobsen, F., Möller-Koop, C., Minner, S., Simon, R., Sauter, G., Steurer, S., Clauditz, T. S., Wilczak, W."IMP3 overexpression occurs in various important cancer types and is linked to aggressive tumor features: A tissue microarray study on 8,877 human cancers and normal tissues". Oncology Reports 39.1 (2018): 3-12.
Chicago
Burdelski, C., Jakani-Karimi, N., Jacobsen, F., Möller-Koop, C., Minner, S., Simon, R., Sauter, G., Steurer, S., Clauditz, T. S., Wilczak, W."IMP3 overexpression occurs in various important cancer types and is linked to aggressive tumor features: A tissue microarray study on 8,877 human cancers and normal tissues". Oncology Reports 39, no. 1 (2018): 3-12. https://doi.org/10.3892/or.2017.6072