Ki-67 antigen expression in relation to clinicopathological variables and prognosis in gastric cancer.
- S Kikuyama
- T Kubota
- K Shimizu
- M Miyakita
Affiliations: Department of Surgery, Saiseikai Central Hospital, Minato-ku, Tokyo 108-0073, Japan.
- Published online on: July 1, 1998 https://doi.org/10.3892/or.5.4.867
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One hundred and thirty surgical specimens of gastric adenocarcinoma were obtained from patients who had undergone radical gastrectomy. The samples were formalin-fixed, paraffin-embedded and used for immunostaining of Ki-67 antigen. Mean Ki-67 index was 41.8% (SD 15. 7%, range 8.2-84.2%). Differentiated carcinomas had a higher Ki-67 index than undifferentiated tumors, although other clinicopathological variables, including lymph node metastasis and depth of invasion showed no correlation with Ki-67 index. In the undifferentiated tumors, Ki-67 index correlated with lymph node involvement. A high Ki-67 index ( 55%) was found to be an independent indicator of poor prognosis in patients with undifferentiated tumors.