Ki-67 antigen expression in relation to clinicopathological variables and prognosis in gastric cancer.

  • Authors:
    • S Kikuyama
    • T Kubota
    • K Shimizu
    • M Miyakita
  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/or.5.4.867
  • Pages: 867-937
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Abstract

One hundred and thirty surgical specimens of gastric adenocarcinoma were obtained from patients who had undergone radical gastrectomy. The samples were formalin-fixed, paraffin-embedded and used for immunostaining of Ki-67 antigen. Mean Ki-67 index was 41.8% (SD 15. 7%, range 8.2-84.2%). Differentiated carcinomas had a higher Ki-67 index than undifferentiated tumors, although other clinicopathological variables, including lymph node metastasis and depth of invasion showed no correlation with Ki-67 index. In the undifferentiated tumors, Ki-67 index correlated with lymph node involvement. A high Ki-67 index ( 55%) was found to be an independent indicator of poor prognosis in patients with undifferentiated tumors.

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July 1998
Volume 5 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Kikuyama, S., Kubota, T., Shimizu, K., & Miyakita, M. (1998). Ki-67 antigen expression in relation to clinicopathological variables and prognosis in gastric cancer.. Oncology Reports, 5, 867-937. https://doi.org/10.3892/or.5.4.867
MLA
Kikuyama, S., Kubota, T., Shimizu, K., Miyakita, M."Ki-67 antigen expression in relation to clinicopathological variables and prognosis in gastric cancer.". Oncology Reports 5.4 (1998): 867-937.
Chicago
Kikuyama, S., Kubota, T., Shimizu, K., Miyakita, M."Ki-67 antigen expression in relation to clinicopathological variables and prognosis in gastric cancer.". Oncology Reports 5, no. 4 (1998): 867-937. https://doi.org/10.3892/or.5.4.867