Different expression patterns of MMP-2 and MMP-9 in breast cancer.

  • Authors:
    • S Y Rha
    • W I Yang
    • J H Kim
    • J K Roh
    • J S Min
    • K S Lee
    • B S Kim
    • H C Chung
  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/or.5.4.875
  • Pages: 875-884
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Abstract

Among the many biological characteristics of cancer, the matrix metalloproteinase (MMPs) is essential for tumor invasion and metastasis. The relationship between MMP-2 and MMP-9 according to tumor progression has not been studied yet. We evaluated the synchronous expression and activation rate of MMP-2 and MMP-9 in breast cancer tissues and compared them to the clinical parameters in order to determine the clinical significance of MMPs and the possibilities of using them as a therapeutic target. The activity of MMPs was evaluated in 121 breast cancer tissues using zymography and the area of activation was calculated by computer-assisted densitometry in comparison to the activity of a positive control (HT-1080). In 121 tumor tissues, 32 (26.4%) did not express any form of MMPs and 19 (15.7%) showed both expression of MMP-2 and MMP-9. We observed that only one tissue expressed MMP-9 alone, while MMP-2 alone was expressed in 69 tissues. In 88 patients with MMP-2 and/or MMP-9 expression, we were unable to observe any correlation between the activity of MMPs expression or activation rate and the clinical parameters. But MMP-2 and MMP-9 activity increased according to T factor. Rapid production of MMP-9 occurred from T2 (p=0.046), while that of MMP-2 occurred from T3 (p=0.004). In conclusion, MMPs activity was organ specific. The major MMPs in breast cancer was MMP-2 and MMPs activity was different with tumor progression. When MMPs are a specific therapeutic target, we should use different inhibitors according to tumor size, in patients at the same stage.

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Jul-Aug 1998
Volume 5 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Rha S, Yang W, Kim J, Roh J, Min J, Lee K, Kim B and Chung H: Different expression patterns of MMP-2 and MMP-9 in breast cancer.. Oncol Rep 5: 875-884, 1998.
APA
Rha, S., Yang, W., Kim, J., Roh, J., Min, J., Lee, K. ... Chung, H. (1998). Different expression patterns of MMP-2 and MMP-9 in breast cancer.. Oncology Reports, 5, 875-884. https://doi.org/10.3892/or.5.4.875
MLA
Rha, S., Yang, W., Kim, J., Roh, J., Min, J., Lee, K., Kim, B., Chung, H."Different expression patterns of MMP-2 and MMP-9 in breast cancer.". Oncology Reports 5.4 (1998): 875-884.
Chicago
Rha, S., Yang, W., Kim, J., Roh, J., Min, J., Lee, K., Kim, B., Chung, H."Different expression patterns of MMP-2 and MMP-9 in breast cancer.". Oncology Reports 5, no. 4 (1998): 875-884. https://doi.org/10.3892/or.5.4.875