The effect of amiloride on the metastatic properties of prostate cancer in the Dunning rat model.

Pilat,M J; Lehr,J E; Quigley,M M; Pienta,K J

doi:10.3892/or.5.4.889

Jul-Aug 1998 Volume 5 Issue 4

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Jul-Aug 1998 Volume 5 Issue 4

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Article

The effect of amiloride on the metastatic properties of prostate cancer in the Dunning rat model.

Authors:
- M J Pilat
- J E Lehr
- M M Quigley
- K J Pienta
View Affiliations / Copyright

Affiliations: Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109-0946, USA.
Pages: 889-981
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Published online on: July 1, 1998

https://doi.org/10.3892/or.5.4.889
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Abstract

Most deaths from cancer result from the metastatic spread of the disease. The antidiuretic amiloride has been shown to inhibit tumor growth and metastasis in several tumor systems. The object of these studies was to examine the effect on the in vitro and in vivo tumor growth and metastasis in the MatLyLu subline of the Dunning model of rat prostate cancer. In vitro, amiloride was found to have cytotoxic effects only at high concentrations, with an IC50 of 100 microg/ml. In vitro analysis of the ability of amiloride to inhibit invasion of MLL cells demonstrated that this drug was ineffective at all concentrations examined. In vivo, amiloride did not inhibit tumor growth or metastases development. Our studies demonstrate that amiloride does not have activity in this model of prostate cancer and suggest it may not be an appropriate therapy for the treatment of prostate cancer.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The effect of amiloride on the metastatic properties of prostate cancer in the Dunning rat model.

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Abstract

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