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Effects of antiprogestins RU486 and ZK98299 on the expression of cell cycle proteins of a medroxyprogesterone acetate (MPA)-induced murine mammary tumor

  • Authors:
    • Maria Giselle Peters
    • Silvia Vanzulli
    • Patricia V. Elizalde
    • Eduardo H. Charreau
    • Maria Mercedes Goin

  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/or.8.2.445
  • Pages: 445-449
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Abstract

This study links the tumor inhibitory effect of anti-progestins RU486 and ZK98299 to the expression of cell cycle proteins. Medroxyprogesterone acetate-induced ductal mammary adenocarcinoma-bearing female BALB/c mice were treated daily either with RU486 or ZK98299, observing tumor growth retardation. p21 increased after 24 h treatment, peaked at day 4 and returned to control levels at day 7. Cyclin D1, cyclin E, CDK2 and CDK4, did not change during treatment. These results suggest that p21 might play a role in early inhibitory stages of tumor growth induced by RU486 and ZK98299.

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March-April 2001
Volume 8 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Peters MG, Vanzulli S, Elizalde PV, Charreau EH and Goin MM: Effects of antiprogestins RU486 and ZK98299 on the expression of cell cycle proteins of a medroxyprogesterone acetate (MPA)-induced murine mammary tumor. Oncol Rep 8: 445-449, 2001
APA
Peters, M.G., Vanzulli, S., Elizalde, P.V., Charreau, E.H., & Goin, M.M. (2001). Effects of antiprogestins RU486 and ZK98299 on the expression of cell cycle proteins of a medroxyprogesterone acetate (MPA)-induced murine mammary tumor. Oncology Reports, 8, 445-449. https://doi.org/10.3892/or.8.2.445
MLA
Peters, M. G., Vanzulli, S., Elizalde, P. V., Charreau, E. H., Goin, M. M."Effects of antiprogestins RU486 and ZK98299 on the expression of cell cycle proteins of a medroxyprogesterone acetate (MPA)-induced murine mammary tumor". Oncology Reports 8.2 (2001): 445-449.
Chicago
Peters, M. G., Vanzulli, S., Elizalde, P. V., Charreau, E. H., Goin, M. M."Effects of antiprogestins RU486 and ZK98299 on the expression of cell cycle proteins of a medroxyprogesterone acetate (MPA)-induced murine mammary tumor". Oncology Reports 8, no. 2 (2001): 445-449. https://doi.org/10.3892/or.8.2.445